The answer to this depends on the interpretation of the call of the question. By that I mean: diet is a necessary but not sufficient variable for maximal muscle growth, same goes for training. Diet should provide the necessary building blocks for muscle growth. Training should provide an optimal stimulus (training is to stimulate not destroy). These two (diet > training) are the number 1 most common limiting factors of muscle growth.
This ties in to recovery: these days, guys are by and large seem mostly on point with their recovery (unless one takes the erroneous "volume is the primary driver of growth" to its extreme, as recovery is in fact most hindered by excessive training volumes). But for the most part, if a guy is on a logical split (PPL, etc.) training 4 day weekly, his recovery (and this is greatly augmented by drug dosage) is near optimal.
Drug dosage is, IMO, not a matter of constantly titrating up absolute dose but rather presenting a greater stimulus in each subsequent blast (this can be by the proper combination of drugs rather than increased dosage). But the fact is that AR activation and in fact number (mRNA expression) is upregulated by testosterone, just as an example. Many drugs offer useful properties that can act in combination with other (adjuvant) drugs that should be individually tailored based on tolerance and response. I consider this knowledge essential and proprietary information of sorts.
Then, genetics: this factor is the absolute bar to muscle mass growth (where the aforementioned factors are necessary but not sufficient to maximize an individual's muscle growth, this factor goes to absolute potential). To me, at bottom, genetics dictate the ceiling for muscle mass growth in terms of drug tolerability vs. response (something I have written about but never shared is the concept of androgen capacity-resilience that encompasses particular genes that vary in expression on an inter-individual basis). Once you reach the ceiling for absolute growth (recruitment and hypertrophy of the available pool of myofibers) there are steps you can take to stimulate muscle cell (myoblasts to myotubes) proliferation & differentiation (involving particular drugs and training methods used appropriately). This is, though, advanced beyond the needs of 98% of the population.