What NOT to use with GH?

[A50#]

I've heard that using Nolva is a bad idea since it lowers Igf-1. Are there other compounds that one should avoid while using GH?

 

[saint808]

I've heard that using Nolva is a bad idea since it lowers Igf-1. Are there other compounds that one should avoid while using GH?

i've never seen anything to back that statement up... where'd you see it?

 

[DOGGCRAPP]

Stimulates the secretion of transforming growth factor-beta (TGF-b which then acts to inhibit the expression and/or activity of TGF-a and IGF-1, two genes that are involved in cell growth and proliferation.

Effects of tamoxifen on insulin-like growth factors, IGF binding proteins and IGFBP-3 proteolysis in breast cancer patients.

Gronbaek H, Tanos V, Meirow D, Peretz T, Raz I, Flyvbjerg A.

Institute of Experimental Clinical Research, Aarhus Kommunehospital, Aarhus University Hospital, Aarhus C, Denmark. [email protected]

BACKGROUND: Recently an association between increased serum insulin-like growth factor I (IGF-I) levels and the development of breast cancer was demonstrated. Tamoxifen used in the postoperative treatment of breast cancer patients may exert significant effects on the IGF-I system. MATERIALS AND METHODS: To examine the effect of Tamoxifen treatment (20 mg/day) on changes in the IGF-I axis in 11 breast cancer patients before and after 4 months of Tamoxifen treatment and compared to 8 healthy subjects. IGF-I, IGF-II, IGFBP-1, IGFBP-2, IGFBP-3 and IGFBP-6 were examined by specific assays. IGFBPs were examined by Western ligand blotting and IGFBP-3 proteolytic activity by specific protease assay. RESULTS: Serum IGF-I was decreased before (63%) and increased during Tamoxifen treatment (60%). Total IGFBP-3 levels measured by IRMA were unchanged, however, intact IGFBP-3 measured by WLB was decreased (58%) before and increased (67%) during Tamoxifen treatment. IGFBP-3 proteolysis was increased before and reduced during treatment. IGFBP-4 and IGFBP-6 were decreased before and increased during Tamoxifen treatment. CONCLUSION: Significant changes in the IGF system were demonstrated before and during Tamoxifen treatment and may in part be involved in the effects of Tamoxifen treatment in breast cancer patients.

Thats a 20 second search. GH works predominantly thru IGF liberation in the liver and Nolvadex blunts that release Saint, I believe clomid does also but arimidex and letro avoid that issue (letro if i remember right even potentiates more of an IGF release--but Im too lazy to look it up again, I studied it a couple years back)

 

[xcelbeyond]

GH works predominantly thru IGF liberation in the liver and Nolvadex blunts that release Saint, I believe clomid does also but arimidex and letro avoid that issue (letro if i remember right even potentiates more of an IGF release--but Im too lazy to look it up again, I studied it a couple years back)

I've read the studies about letrozole substantially increasing IGF-1 and anastrozole to some degree. Problem with these anti-aromatases is they seem to wreek havoc on your lipid profile where nolva actually improves it

xcel

 

[saint808]

Stimulates the secretion of transforming growth factor-beta (TGF-b which then acts to inhibit the expression and/or activity of TGF-a and IGF-1, two genes that are involved in cell growth and proliferation.

Effects of tamoxifen on insulin-like growth factors, IGF binding proteins and IGFBP-3 proteolysis in breast cancer patients.

Gronbaek H, Tanos V, Meirow D, Peretz T, Raz I, Flyvbjerg A.

Institute of Experimental Clinical Research, Aarhus Kommunehospital, Aarhus University Hospital, Aarhus C, Denmark. [email protected]

BACKGROUND: Recently an association between increased serum insulin-like growth factor I (IGF-I) levels and the development of breast cancer was demonstrated. Tamoxifen used in the postoperative treatment of breast cancer patients may exert significant effects on the IGF-I system. MATERIALS AND METHODS: To examine the effect of Tamoxifen treatment (20 mg/day) on changes in the IGF-I axis in 11 breast cancer patients before and after 4 months of Tamoxifen treatment and compared to 8 healthy subjects. IGF-I, IGF-II, IGFBP-1, IGFBP-2, IGFBP-3 and IGFBP-6 were examined by specific assays. IGFBPs were examined by Western ligand blotting and IGFBP-3 proteolytic activity by specific protease assay. RESULTS: Serum IGF-I was decreased before (63%) and increased during Tamoxifen treatment (60%). Total IGFBP-3 levels measured by IRMA were unchanged, however, intact IGFBP-3 measured by WLB was decreased (58%) before and increased (67%) during Tamoxifen treatment. IGFBP-3 proteolysis was increased before and reduced during treatment. IGFBP-4 and IGFBP-6 were decreased before and increased during Tamoxifen treatment. CONCLUSION: Significant changes in the IGF system were demonstrated before and during Tamoxifen treatment and may in part be involved in the effects of Tamoxifen treatment in breast cancer patients.

Thats a 20 second search. GH works predominantly thru IGF liberation in the liver and Nolvadex blunts that release Saint, I believe clomid does also but arimidex and letro avoid that issue (letro if i remember right even potentiates more of an IGF release--but Im too lazy to look it up again, I studied it a couple years back)

interesting study.... which seriously... i have never seen. time for some pub med to see if they have a lkittle more. thanks DC.

 

[MikeS]

Thats what I call answering a question. Thanks DC.