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After a lot research I finally decided to order a few months supply of this product. It is to be injected once per week at a dosage of about 3mg/kg.
I am really hoping it will clear up any issues I have with inflammation of the joints.
Maybe someone here has some experience with they would like to share?
Otherwise I would be happy to share my results. Hoping to begin treatment
oct 1.
Courtesy of Wikipedia:
After a series of four to six intra-articular PPS injections into knees of human volunteers, there was a significant increase in the size of the synovial fluid hyaluronan without causing any inflammation or bleeding into the joint cavity.[23] Preliminary reports of an open study of 23 patients with mild to moderate OA of the hand, hip, or knee, found that CaPPS (2 mg/kg intramuscularly once a week for 5 weeks) provided relief of symptoms and normalised hematologic parameters of coagulation and thrombolysis.[24] Another preliminary report described the first 31 of 86 patients with OA of the knee who were subjected to intra-articular sodium PPS injections (n=15) compared to an equivalent volume of IA Ringer's solution (n=16) under double-blind conditions.[25] NaPPS was significantly better than placebo for patient stiffness, walking on a level surface and pain in the previous 48 hours and previous month for multiple time points after treatment. The patients who had intra-articular PPS injections had synovial fluid with significantly better viscoelasticity (lubricating properties) due to significantly higher molecular weight hyaluronan.[26]
When eleven women with knee or hip OA were injected with 3 mg/kg NaPPS, both hepatolipases and lipoprotein lipases were significantly elevated in their plasma for at least eight hours but had returned to normal levels by 24 hours.[13] A double blind, placebo-controlled clinical study in 114 patients with osteoarthritis of the knee was performed in Perth, Australia where patients either received a salt solution or sodium PPS at 3 mg/ kg as an intramuscular injection once weekly for 4 weeks.[27] Overall, NaPPS treatment significantly improved the duration of joint stiffness and pain at rest compared with controls for 20 weeks after the cessation of treatment, and significantly improved pain on walking and overall function for 8 weeks after the cessation of treatment. Twenty patients with knee OA were assessed clinically at Nagasaki University Hospital in a single-center, open-label trial. Treatment consisted of 6 weekly subcutaneous injections of pentosan (2 mg/kg). Knee flexion, pain while walking, pain after climbing up and down stairs were improved significantly for up to a year.
I am really hoping it will clear up any issues I have with inflammation of the joints.
Maybe someone here has some experience with they would like to share?
Otherwise I would be happy to share my results. Hoping to begin treatment
oct 1.
Courtesy of Wikipedia:
After a series of four to six intra-articular PPS injections into knees of human volunteers, there was a significant increase in the size of the synovial fluid hyaluronan without causing any inflammation or bleeding into the joint cavity.[23] Preliminary reports of an open study of 23 patients with mild to moderate OA of the hand, hip, or knee, found that CaPPS (2 mg/kg intramuscularly once a week for 5 weeks) provided relief of symptoms and normalised hematologic parameters of coagulation and thrombolysis.[24] Another preliminary report described the first 31 of 86 patients with OA of the knee who were subjected to intra-articular sodium PPS injections (n=15) compared to an equivalent volume of IA Ringer's solution (n=16) under double-blind conditions.[25] NaPPS was significantly better than placebo for patient stiffness, walking on a level surface and pain in the previous 48 hours and previous month for multiple time points after treatment. The patients who had intra-articular PPS injections had synovial fluid with significantly better viscoelasticity (lubricating properties) due to significantly higher molecular weight hyaluronan.[26]
When eleven women with knee or hip OA were injected with 3 mg/kg NaPPS, both hepatolipases and lipoprotein lipases were significantly elevated in their plasma for at least eight hours but had returned to normal levels by 24 hours.[13] A double blind, placebo-controlled clinical study in 114 patients with osteoarthritis of the knee was performed in Perth, Australia where patients either received a salt solution or sodium PPS at 3 mg/ kg as an intramuscular injection once weekly for 4 weeks.[27] Overall, NaPPS treatment significantly improved the duration of joint stiffness and pain at rest compared with controls for 20 weeks after the cessation of treatment, and significantly improved pain on walking and overall function for 8 weeks after the cessation of treatment. Twenty patients with knee OA were assessed clinically at Nagasaki University Hospital in a single-center, open-label trial. Treatment consisted of 6 weekly subcutaneous injections of pentosan (2 mg/kg). Knee flexion, pain while walking, pain after climbing up and down stairs were improved significantly for up to a year.
