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Aldactone--Lisinopril

Kidrok

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Jun 6, 2002
Messages
138
I am on lisinopril for high blood pressure. Since I'm preparing for a show I decided to do some research to see what if any drug interaction there may be if I used aldactone the final week to help with dropping water. My findings were interesting. I've copied some of the key information below regarding the 2 drugs. My conclusion is that although they are of different drug classifications (aldactone is a diuretic and lisinopril an ACE inhibtor), they serve very similar functions. So, I plan to not use aldactone but instead increase my daily bp medication (the lisinopril) for the last 3-4 days and see what the effect is. The show is still 7 weeks away but if anyone is interested in how it seems to work then feel free to PM me for results. I may even experiment with increasing my bp meds for a few days sometime in the next few weeks.


Lisinopril
The effects of Prinivil in hypertension and heart failure appear to result primarily from suppression of the renin-angiotensin-aldosterone system. Inhibition of ACE results in decreased plasma angiotensin II, which leads to decreased vasopressor activity and to decreased aldosterone secretion. It may be used alone as initial therapy or concomitantly with other classes of antihypertensive agents. It is indicated as adjunctive therapy in the management of heart failure in subjects who are not responding adequately to diuretics and digitalis. Decreases concentrations of angiotensin II. This results in vasodilation, as well as reduced sympathetic activity, probably by diminution of angiotensin's presynaptic effects on norepinephrine release. Decreased concentrations of aldosterone. This results in reduced salt and water retention.

Aldactone
Aldactone flushes excess salt and water from the body and controls high blood pressure. It is used in the diagnosis and treatment of hyperaldosteronism, a condition in which the adrenal gland secretes too much aldosterone (a hormone that regulates the body's salt and potassium levels). It is also used in treating other conditions that require the elimination of excess fluid from the body. These conditions include congestive heart failure, high blood pressure, cirrhosis of the liver, kidney disease, and unusually low potassium levels in the blood. When used for high blood pressure, Aldactone can be taken alone or with other high blood pressure medications.
 

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