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Ancillaries and IGF

IronLion2

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Nov 10, 2017
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I've went through almost every thread from the past 10 years on anti aromatase and dopamine antagonists, most of its parroted garbage or studies on women during menopause.

Other than overdosing to the point of e2 or PRL/PRG being crushed, is there anything to worry about? Hindrance to GH to IGF conversion, or an advantage? Neither DA's or AI's were used until the late 70s and they did just fine without them.

Hate to bring up such an asked topic, but I just havent seen good evidence from either side of the debate
 

Landmonster

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Aug 5, 2007
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978
There seems to be considerable evidence that Tamoxifen and Raloxifene lower IGF-1 levels by considerable amounts. Clomid does too.

This is not really discussed much, or people blow it off as insignificant amounts. From what I have seen it could be be 25-40% declines


Those are SERMS, not AIs.

There's not much advantage to any of them. Besides the intended effects.
Praxipexole has a slight increase in GH for a few hours after dosing it.
 
Last edited:

IronLion2

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Nov 10, 2017
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1,802
Stewie confirmed my belief, essentially too much estrogen will lower free test so you want ratio or proportion of e2 to total test, too little e2 not only causes side effects but will start to lower performance.

Prami and caber are still up for debate? The studies on prami inhibiting GHIH is a very small sample size and inconclusive. No idea about caber?

My first large blast was 700NPP/550TestP, I didnt use an AI nor a DA and that was my largest ever, though I was also 15% bodyfat or more so it's hard to compare.
 

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