Over the years, I have tried nearly everything that is available over the counter. Also, went through at least a dozen medications from the doctor. None of them really worked. Then I found Kratom - and it has literally changed my life. May not work for everyone, but this was an absolute game changer for me. Complete 180 degree turnaround... I find green malay to be the best for my mood (here is a link to what I use -
https://www.naturescurekratom.com/product/green-malay-kratom-kilo/ ).
The only other thing that remotely helped was ashwaghanda and L-theanine for anxiety. The effect was very slight, and you need to take it every day to build up in your system a little bit.
Hope this helps.