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Can someone explain what this means...

thewarrior23

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Jan 4, 2008
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76
Been ressearching Formastane and came across this info on some "real clinical reasearch" that was done on it.

4-Hydroxyandrostenedione has also been given orally. Even though there is a marked first-pass effect with conversion in the liver to a glucuronidated derivative, oral doses of 250 mg reduce plasma estradiol by 53% and doses up to 1,000 mg produce no further suppression. The response rate after 3 months of therapy was 33%, and the only serious side effect from the oral dosage was leukopenia in a single patient.38

Formastane is supposed to reduce E2 fairly quickly after you administer it, within a few days and top out at about 50% E2 reduction. My question is whats in bold about the 33% after 3 months.

Does than mean after 3 months usage, instead of blocking 50% E2 it will only be blocking 33% so after about 4 months use ur body wont respond to it very much so you would need to switch to another AI, is that what that means??
 

thewarrior23

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Jan 4, 2008
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I also got this from another research site,
Formestane (4-hydroxyandrostenedione) is an aromatase inhibitor which significantly reduces plasma levels of estrogen and has shown antitumour activity in postmenopausal women with breast cancer. Objective response rates in heavily pretreated patients with advanced breast cancer generally range between 20 and 30% during treatment with intramuscular formestone 250 or 500mg once every 2 weeks, and a further 20 to 30% of patients experience disease stabilisation. The median duration of response is between 8 and 14 months.

If I understand correctly wouldnt that mean that ppl are responding to form for between 8-14months give or take?? IS that what that means? Just want to know if I can use form on longer 16-20 week cycles???
 

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