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Can you desensitize from PDE-5 inhibitors?

MinuteMaid

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Wondering about long term users of Viagra, Cialis, Levitra... if those drugs start losing effect over time (i'm talking to those using them like 3-4 times a week), not talking about lower libido but purely the erections.

What's your intake and history?
 
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buck

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Libido is in the brain and these sort of drugs should not affect that. They work in smooth muscle tissue. I have used these low dose for some time with consistent effects. People expectations may change over time which can change how well we think they work. Once the excitement of playing with a new toy wears off that does not mean the new toy is broken.
 

nothuman

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I thought I was desensitizing to cialis but now I'm starting to wonder if my source isn't as good as it once was. I switched to Monster cialis the other day and feel like it's stronger. Confusing the crap out of me tbh
 

Stewie

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Tachyphylaxis from PDE5-i is extremely rare.
 
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ChemJr.

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I used to use 5-10mg and finding myself using 10-20 now so idk if I need more due to some lifestyle & health changes or if one does indeed build a tolerance, but personally I think one can. I believe I was before changes in lifestyle/ health. Just my opinion.
Reason- a little less than 10mg and I'd be walking around with a semi all day. Now that takes 15mg. However I can go much longer in the bedroom with higher doses so I guess my prostate got used to it but my pecker is still relatively the same? If that makes any sense.

Sent from my SAMSUNG-SM-T377A using Professional Muscle mobile app
 

itconsulting

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I used to use 5-10mg and finding myself using 10-20 now so idk if I need more due to some lifestyle & health changes or if one does indeed build a tolerance, but personally I think one can. I believe I was before changes in lifestyle/ health. Just my opinion.
Reason- a little less than 10mg and I'd be walking around with a semi all day. Now that takes 15mg. However I can go much longer in the bedroom with higher doses so I guess my prostate got used to it but my pecker is still relatively the same? If that makes any sense.

Sent from my SAMSUNG-SM-T377A using Professional Muscle mobile app

Make sense, but do you think it's due to a lower libido/general attraction or purely the drug working less effectively?
 

Papa Van Smack

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The drug working less effectively is the only option there. These drugs do not effect desire for sex but only erection quality. I've found that if used frequently, taking a couple of weeks off can be of benefit.
 

MinuteMaid

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The drug working less effectively is the only option there. These drugs do not effect desire for sex but only erection quality. I've found that if used frequently, taking a couple of weeks off can be of benefit.

What about switching up drug, like 4 weeks Levitra, 4 weeks Viagra...
 

nothuman

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I thought I was desensitizing to cialis but now I'm starting to wonder if my source isn't as good as it once was. I switched to Monster cialis the other day and feel like it's stronger. Confusing the crap out of me tbh

Going back to this, I have no doubt monster's cialis is better than the Ceebis I have been using on alldaychemist. I think they started underdosing it on ADC because I feel it used to work better. Or maybe it's all in my head. It's strange.

Anyone else use ceebis on ADC?
 

heavyhitter

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Going back to this, I have no doubt monster's cialis is better than the Ceebis I have been using on alldaychemist. I think they started underdosing it on ADC because I feel it used to work better. Or maybe it's all in my head. It's strange.

Anyone else use ceebis on ADC?

ive used lots of Cialis over the years from research grade to allday. Ive been using monsters Cialis for probably a year or so now and youre right, its on par or better than others that ive tried. I break the tabs into quarters and take 1 quarter every morning on an empty stomach. Great pumps in the gym and plenty of stamina elsewhere
 

nothuman

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ive used lots of Cialis over the years from research grade to allday. Ive been using monsters Cialis for probably a year or so now and youre right, its on par or better than others that ive tried. I break the tabs into quarters and take 1 quarter every morning on an empty stomach. Great pumps in the gym and plenty of stamina elsewhere

Now I'm wondering if the ceebis from ADC has suddenly become underdosed and I was blaming the fact I could take 2 tabs and still not guaranteed to get an erection. I was blaming it on E2 or switching to a daily sub-q injection regimen but maybe it was just the potency was worse? Half a tab of monster cialis (10mg) worked far better than 40mg of ceebis. I guess I have to figure this all out.
 

suppdude

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Going back to this, I have no doubt monster's cialis is better than the Ceebis I have been using on alldaychemist. I think they started underdosing it on ADC because I feel it used to work better. Or maybe it's all in my head. It's strange.



Anyone else use ceebis on ADC?



I’ve got nothing to compare ADC to. I need to grab another source and try to compare.


Sent from my iPhone using Tapatalk
 

CC

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Libido and erectile response are subject to many factors.

For me stress, lack of sleep, lack of exercise, low carb intake, hormonal fluctuations, anxiety, etc all have a negative impact.

The biggest one has to be anxiety. If your mind believes you have a problem then there's a good chance you will have that problem.
 

ChemJr.

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Make sense, but do you think it's due to a lower libido/general attraction or purely the drug working less effectively?
If anything libido has gone up since trt doc has gotten the #s dialed in, and my occasional addition of certain things. Also the one I've been spending time with certainly makes things work easier.
I definitely feel it's my body desensitized to the tadalafil over time. Sorry for late response.
 

totalrecomp

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Many factors to consider:

Is the body increasing production PDE-5? maybe
Is the indian pharma underdosed? maybe
Is the UG/research overdosed? maybe
 

Macrocupcake124

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Now I'm wondering if the ceebis from ADC has suddenly become underdosed and I was blaming the fact I could take 2 tabs and still not guaranteed to get an erection. I was blaming it on E2 or switching to a daily sub-q injection regimen but maybe it was just the potency was worse? Half a tab of monster cialis (10mg) worked far better than 40mg of ceebis. I guess I have to figure this all out.



Any reason you don't buy the powder and diy. I have my own oral solution and purple panda caps when I need something more portable.

I've been using it off and on for almost 10 years. No desensitization for me. Mental reliance is an issue though.

Sent from my iPhone using Tapatalk
 
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Samson48

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I was taking Viagra for years every now and then.

It eventually stopped working.

The Viagra was straight from the pharmacy on a prescription so it wasn't that.

I did a search online and found that this is normal and happens to guys.
 

SD1959

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I thought I was desensitizing to cialis but now I'm starting to wonder if my source isn't as good as it once was. I switched to Monster cialis the other day and feel like it's stronger. Confusing the crap out of me tbh

I've used plenty of useless c and v over the last few years. So you like Monster's?
 

rfire

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I've been using Cialis for several years, many different sources... Some worked better than others... For the past year or so I've been using Ox labs low dose 10mg Cialis and haven't had a problem yet... As long as I'm turned on, the cialis does it's job!! I don't believe I have desensitized at all...
 

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