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Clenbuterol reduces insulin resistance

johnjuanb1

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Those of us using HGH are always looking for ways to help reduce insulin resistance. Mind you this study was done on rats. Rats are often used in studies because they respond similarly to humans in regards to drug effects.

Effects of clenbuterol on insulin resistance in conscious obese Zucker rats.
Pan SJ, et al. Am J Physiol Endocrinol Metab. 2001.
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Abstract
The present study was conducted to determine the effect of chronic administration of the long-acting beta(2)-adrenergic agonist clenbuterol on rats that are genetically prone to insulin resistance and impaired glucose tolerance. Obese Zucker rats (fa/fa) were given 1 mg/kg of clenbuterol by oral intubation daily for 5 wk. Controls received an equivalent volume of water according to the same schedule. At the end of the treatment, rats were catheterized for euglycemic-hyperinsulinemic (15 mU insulin. kg(-1). min(-1)) clamping. Clenbuterol did not change body weight compared with the control group but caused a redistribution of body weight: leg muscle weights increased, and abdominal fat weight decreased. The glucose infusion rate needed to maintain euglycemia and the rate of glucose disappearance were greater in the clenbuterol-treated rats. Furthermore, plasma insulin levels were decreased, and the rate of glucose uptake into hindlimb muscles and abdominal fat was increased in the clenbuterol-treated rats. This increased rate of glucose uptake was accompanied by a parallel increase in the rate of glycogen synthesis. The increase in muscle glucose uptake could not be ascribed to an increase in the glucose transport protein GLUT-4 in clenbuterol-treated rats. We conclude that chronic clenbuterol treatment reduces the insulin resistance of the obese Zucker rat by increasing insulin-stimulated muscle and adipose tissue glucose uptake. The improvements noted may be related to the repartitioning of body weight between tissues.
 

Massthetics

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Those of us using HGH are always looking for ways to help reduce insulin resistance. Mind you this study was done on rats. Rats are often used in studies because they respond similarly to humans in regards to drug effects.

Effects of clenbuterol on insulin resistance in conscious obese Zucker rats.
Pan SJ, et al. Am J Physiol Endocrinol Metab. 2001.
Show full citation
Abstract
The present study was conducted to determine the effect of chronic administration of the long-acting beta(2)-adrenergic agonist clenbuterol on rats that are genetically prone to insulin resistance and impaired glucose tolerance. Obese Zucker rats (fa/fa) were given 1 mg/kg of clenbuterol by oral intubation daily for 5 wk. Controls received an equivalent volume of water according to the same schedule. At the end of the treatment, rats were catheterized for euglycemic-hyperinsulinemic (15 mU insulin. kg(-1). min(-1)) clamping. Clenbuterol did not change body weight compared with the control group but caused a redistribution of body weight: leg muscle weights increased, and abdominal fat weight decreased. The glucose infusion rate needed to maintain euglycemia and the rate of glucose disappearance were greater in the clenbuterol-treated rats. Furthermore, plasma insulin levels were decreased, and the rate of glucose uptake into hindlimb muscles and abdominal fat was increased in the clenbuterol-treated rats. This increased rate of glucose uptake was accompanied by a parallel increase in the rate of glycogen synthesis. The increase in muscle glucose uptake could not be ascribed to an increase in the glucose transport protein GLUT-4 in clenbuterol-treated rats. We conclude that chronic clenbuterol treatment reduces the insulin resistance of the obese Zucker rat by increasing insulin-stimulated muscle and adipose tissue glucose uptake. The improvements noted may be related to the repartitioning of body weight between tissues.
That's a lot of clen

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Gunsmith

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Clen makes me feel terrible , like I have the flu even with doses at 80mcg/ED

Hate to say it but I'd rather use DNP if Metformin wasn't an option
 

goal245

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who will be the first to take 100MG of clen to see if this really works?
 

Elvia1023

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who will be the first to take 100MG of clen to see if this really works?

JJ I know what you are thinking but please no :D

Those little rats must have felt awful :eek:
 

Elvia1023

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If you want to increase slin sensitivity just use metformin, berberine, melanotan 2 (if you want to get tanned too), low carbs even dnp (etc). I would never high dose clen for this or any purpose.
 

concreter

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I have only made it to day 3 on 20mgs of Clen!
Had the Fire Lit !
 
Last edited:

johnjuanb1

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Definitely wouldn't suggest ANYONE to ever use that amount. For us bodybuilders we want MCG amounts. 100-120MCG is about all I can tolerate personally.

Definitely! No high doses. I was just looking for things we can supplement occasionally to help reduce insulin resistance.
 

johnjuanb1

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If you want to increase slin sensitivity just use metformin, berberine, melanotan 2 (if you want to get tanned too), low carbs even dnp (etc). I would never high dose clen for this or any purpose.

I was thinking take a dnp capsule occasionally, Clen occasionally, melanotan II occasionally, etc. Nothing frequently! I just don’t feel good on metformin and don’t like the idea of it. It doesn’t seem like a drug conducive to building muscle. Of course, the same can be said about DNP. Hahaha 🤣
 

dagreat

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Type 1 diabetic here.
Clen messed up my sugars bad.
Had to triple my insulin dose and was still nowhere near my usual blood sugar level
 
Last edited:

IronLion2

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Can you imagine how dry and granite those lab rats on that much clen. All the other test subjects were jealous af.
 

powerof2

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I was thinking take a dnp capsule occasionally, Clen occasionally, melanotan II occasionally, etc. Nothing frequently! I just don’t feel good on metformin and don’t like the idea of it. It doesn’t seem like a drug conducive to building muscle. Of course, the same can be said about DNP. Hahaha 🤣



I have been trying this approach with metformin. Using it on rest days. It messes with my appetite to much. I might have to give the dnp thing a try on rest days with metformin. Go no carb high fats? But then again will dnp mess with gains beings it in your system for so long?


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