Update. Haven't been here largely because of the little shit academics who think they are experts in areas in which they freely admit they have never actually experienced. They will say that this experience is useless while in the same breath admitting they have never actually interacted with a person/patient in a professional medical capacity in their life. Shit/Waterscholar and this Euro moron with the Nasser avatar who I can't even remember the name of, you know who I'm talking about. They will also say that experience in these matters "has never been the standard here." But in contrast, if someone who has no experience in PEDs were to come here and espouse knowledge they would be immediately rebutted as someone with no experience. So it has actually always been the standard here. It's just that these little academic shits all of sudden think they are experts in areas in which they have no experience because they can read. It's a phenomenon unique to COVID that somehow makes ignorant inexperienced unqualified uneducated people believe they are experts.
I was very fortunate to have secured a contract with Pfizer for the COVID vaccine. Pfizer BNT162b2/aka B2 is the winner in the vaccine race without a doubt. We've administered IP/investigational product or placebo (bacstat NaCL) to 144 people with only 2 adverse events of pain and erythema at the injection site. Antibody titers in humans are 3-4x that of convalescent plasma. They were even higher in monkeys. Meaning if you were infected with COVID naturally you would have 3-4x fewer antibodies than if you received this vaccine. This is coupled with an equally strong T cell immunity response. Whether this is protective or not and how long it lasts we do not know, that is the purpose of the study. Suffice to say, if antibodies and T cell response are not protective for a period of at least 4-6 months then there really is no hope in combating this with a vaccine. AEs/adverse events in 18-55 year olds is 16%, in 65-85 yo they experienced zero adverse events. Thus the younger and more robust your immune response the more likely you are to experience an AE. Pfizer B2 mRNA encodes your own cell machinery to produce the spike protein that is present on the surface of SARS-CoV-2. Everyone has seen the COVID animation by now. Your body then produces antibodies in response to this spike protein. Pfizer B1 vaccine, which has since been dropped, was also mRNA but targeted the receptor that COVID uses to enter the cell. AEs for Pfizer B1 in 18-55 were 50% which is extremely high and 16% in 65-85. Moderna mRNA has also experienced similarly high AE rates as the now defunct Pfizer B1 , even higher. Every single person who received the dose in phase 1 that Moderna is moving forward with, 100mcg, and the higher dose they tested, 250mcg, experienced an adverse event after the injection. AstraZeneca was halted two days ago due to an SAE/severe adverse reaction. In phase 2, out of 1000 subjects in AZ/Oxford adenovirus vaccine 600/60% experienced an adverse event post injection. Moderna mRNA, Pfizer B2 mRNA, and AZ adenovirus are not well tolerated by a large margin compared to Pfizer B2. Immunogenicity for B2 is greater or equal to Moderna, AZ, and old Pfizer B1. Current Pfizer B2 dose is 30mcg IM x 2 doses 19-23d apart.
Evidence is still out on HCQ as prophylaxis as no proper study has been performed nor is it likely to happen. I've been on HCQ prophylaxis for 6 months, since March. Maybe it does something good, maybe it doesn't. But it does no harm. I've seen hundreds of people specific to COVID, live in L.A., traveled 5x on commercial flights to other areas since March and I have not contracted COVID. To qualify, for all you academic shits who somehow believe I don't understand that this is proof of nothing despite the fact that I do this for a living while you have zero experience, go fuck yourself.
If you have legitimate questions about the vaccine I will be happy to entertain. If you are a moronic anti vaxxer same applies to you as these academics, go fuck yourself. We were at 28.500 subjects today study wide with an initial 30k subjects. But a little greater than 80% are white people which the FDA does not find acceptable. Today they decided to expand to 44k subjects due to this issue, closing sites with little to zero Hispanic and black access in favor of sites like us in L.A. who agree not to see any more white people starting next week. This will slow things down considerably as these populations are simply not responsive due to what can only be described as ignorance despite the fact that they are in the greatest need. They believe crazy shit like they believe Church's fried chicken makes black men sterile and other equally unbelievable beliefs. In non-Hispanic caucasions, there has been an overwhelming response that I honestly didn't expect. There are literally hundreds of people I will not be able to schedule as we struggle to enroll Hispanics and AAs.
Rex.
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www.cuimc.columbia.edu
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