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- Mar 16, 2007
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Something to think about, if you do get covid-19. Might want to adjust what you're taking. 10,000 more men have died in the US from this, as compared to women.
Lowering Testosterone May Reduce Severity of COVID-19
Lowering testosterone may prevent the new coronavirus from entering lung cells and lessen COVID-19 severity, new Columbia University research suggests. A trial has now begun in three VA hospitals.www.cuimc.columbia.edu
"The new coronavirus cannot enter cells without the help of the TMPRSS2 proteins on our lung cells,” Goldstein says. “Our analysis suggests that decreasing testosterone will lower TMPRSS2, interfere with viral entry, and reduce the severity or duration of COVID-19.”
"A recent study by other researchers reports that the lung cells of men have more TMPRSS2 and that TMPRSS2 levels are greater in older individuals compared with younger people."
Well, fewer women are dying but we don't know for sure why. Could be testosterone.If this were true wouldn't we be seeing BBer's dropping like flies or for that matter most pro athletes?
Low testosterone may impair immune response in men with COVID-19
Low serum testosterone levels may predispose older men to worse COVID-19 outcomes and could explain the higher coronavirus case fatality rate among men compared with women, according to a literature review. “To put it simply, men have a basal, biological predisposition to get sick from COVID-19...www.healio.com
I guess this article is the opposite side of the same coin?
Was just watching Deal or No Deal with Howie Mandel. He's a big germaphobe and OCD. I wonder how he's handling this whole crisis.
Michael Jackson was wearing a mask years ago. Gloves too.
Yep, he and Howie both. Now it's not socially acceptable to go out without a mask.Everyone thought Michael Jackson was crazy. I guess he was just ahead of his time.
Thats too bad, but it sounds like he will be ok even though he's in stage 4. That's great. Gives me a bit of hope if I get sick.My sister in Florida has been really careful to avoid the virus. Her husband has stage 4 cancer, so he's in a high risk group. She didn't want her kid getting it either, obviously. They've been strict about wearing masks in public, washing their hands, sanitizing everything, etc.
Now they all have it. The one girl at my brother in law's job who wasn't regularly wearing a mask came down with it first. Now half the employees at that store are sick. My brother in law is doing surprisingly well. My sister says she feels like she has the worst flu of her life. My nephew is already feeling better after just a few days.
Thats too bad, but it sounds like he will be ok even though he's in stage 4. That's great. Gives me a bit of hope if I get sick.
Goes to show that masks aren't 100% protection, surgical masks probably offer little protection against getting it but it's better than nothing. Was the female spreader not wearing her mask at work, or was that just outside work where she wasn't using one?
If this were true wouldn't we be seeing BBer's dropping like flies or for that matter most pro athletes?
Low testosterone may impair immune response in men with COVID-19
Low serum testosterone levels may predispose older men to worse COVID-19 outcomes and could explain the higher coronavirus case fatality rate among men compared with women, according to a literature review. “To put it simply, men have a basal, biological predisposition to get sick from COVID-19...www.healio.com
I guess this article is the opposite side of the same coin?
From what? The coronavirus? Tons of athletes have it, they don't even know they have it if they weren't required to get tested endlessly. I saw one college athlete (Indiana OL I think) mom saying on facebook that it gave her son "permanent heart damage." What the article failed to say was he didn't even know he had it, he got tested, they ran him an EKG, and it showed his heart wasn't in the best shape. A 300lb Plus 19 year old, no surprise. Obesity tends to strain the heart. It was spun to say that the virus gave him "permanent heart" damage and repeated 1000 times over.
So yeah that's my point. Seems most high level athletes that have gotten it (Covid), all recovered and/or barely felt ill. I would imagine that "many" of these athletes have an elevated testosterone level if not naturally then from a bottle. So it's hard for me to fathom from the article Maldorf posted how an elevated testosterone level might make you MORE prone to a bad outcome. Most elderly men are hypogonadal with total/free test in the gutter already.
I wish there were a test to know your risk so you could either hunker down and wait for a vaccine or relax your anxiety and know if you do get it, it's not going to kill you. What makes one guy lose his sense of smell/taste and barely notice they have it and another go into ARDS and die?
The researchers analyzed the blood of 299 patients diagnosed with COVID-19 admitted to GW Hospital between March and May, 200 of whom had all five biomarkers being evaluated – IL-6, D-dimer, CRP, LDH and ferritin. They found that elevated levels of these biomarkers were linked to inflammation and bleeding disorder, increasing their risk for ICU admission, invasive ventilatory support, and death. They even pinpointed the level at which the odds of death were the highest, when the LDH level was greater than 1200 units/l and a D-dimer level was greater than 3 μg/ml.
Researchers hope their findings will help physicians be able to predict outcomes for coronavirus patients, resulting in a more effective treatment protocol.
"We hope these biomarkers help physicians determine how aggressively they need to treat patients, whether a patient should be discharged, and how to monitor patients who are going home, among other clinical decisions," Shant Ayanian, MD, first author of the study and assistant professor of medicine at the GW School of Medicine and Health Sciences, added.
From what? The coronavirus? Tons of athletes have it, they don't even know they have it if they weren't required to get tested endlessly. I saw one college athlete (Indiana OL I think) mom saying on facebook that it gave her son "permanent heart damage." What the article failed to say was he didn't even know he had it, he got tested, they ran him an EKG, and it showed his heart wasn't in the best shape. A 300lb Plus 19 year old, no surprise. Obesity tends to strain the heart. It was spun to say that the virus gave him "permanent heart" damage and repeated 1000 times over.
LOL! Stanozolol and Vitamin D amongst others!
A Supercomputer Analyzed Covid-19 — and an Interesting New Theory Has Emerged
A closer look at the Bradykinin hypothesiselemental.medium.com
Pfizer BNT162b2/aka B2 is the winner.
Current Pfizer B2 dose is 30mcg IM x 2 doses 19-23d apart.
Antibody titers in humans are 3-4x that of convalescent plasma.
Suffice to say, if antibodies and T cell response are not protective for a period of at least 4-6 months then there really is no hope in combating this with a vaccine.
Thus the younger and more robust your immune response the more likely you are to experience an AE.
Yeah, that guy is a total dick. I was shocked when he pointed out that you cannot rely on anecdotal evidence as a doctor, nor on badly designed observational studies. How rude to remind you of the fact that its professional researchers rather than practitioners like yourself who set treatment guidelines. I mean I can see just how butthurt you still are about it.Update. Haven't been here largely because of the little shit academics who think they are experts in areas in which they freely admit they have never actually experienced. They will say that this experience is useless while in the same breath admitting they have never actually interacted with a person/patient in a professional medical capacity in their life. Shit/Waterscholar and this Euro moron with the Nasser avatar who I can't even remember the name of, you know who I'm talking about. They will also say that experience in these matters "has never been the standard here." But in contrast, if someone who has no experience in PEDs were to come here and espouse knowledge they would be immediately rebutted as someone with no experience. So it has actually always been the standard here. It's just that these little academic shits all of sudden think they are experts in areas in which they have no experience because they can read. It's a phenomenon unique to COVID that somehow makes ignorant inexperienced unqualified uneducated people believe they are experts.
I was very fortunate to have secured a contract with Pfizer for the COVID vaccine. Pfizer BNT162b2/aka B2 is the winner in the vaccine race without a doubt. We've administered IP/investigational product or placebo (bacstat NaCL) to 144 people with only 2 adverse events of pain and erythema at the injection site. Antibody titers in humans are 3-4x that of convalescent plasma. They were even higher in monkeys. Meaning if you were infected with COVID naturally you would have 3-4x fewer antibodies than if you received this vaccine. This is coupled with an equally strong T cell immunity response. Whether this is protective or not and how long it lasts we do not know, that is the purpose of the study. Suffice to say, if antibodies and T cell response are not protective for a period of at least 4-6 months then there really is no hope in combating this with a vaccine. AEs/adverse events in 18-55 year olds is 16%, in 65-85 yo they experienced zero adverse events. Thus the younger and more robust your immune response the more likely you are to experience an AE. Pfizer B2 mRNA encodes your own cell machinery to produce the spike protein that is present on the surface of SARS-CoV-2. Everyone has seen the COVID animation by now. Your body then produces antibodies in response to this spike protein. Pfizer B1 vaccine, which has since been dropped, was also mRNA but targeted the receptor that COVID uses to enter the cell. AEs for Pfizer B1 in 18-55 were 50% which is extremely high and 16% in 65-85. Moderna mRNA has also experienced similarly high AE rates as the now defunct Pfizer B1 , even higher. Every single person who received the dose in phase 1 that Moderna is moving forward with, 100mcg, and the higher dose they tested, 250mcg, experienced an adverse event after the injection. AstraZeneca was halted two days ago due to an SAE/severe adverse reaction. In phase 2, out of 1000 subjects in AZ/Oxford adenovirus vaccine 600/60% experienced an adverse event post injection. Moderna mRNA, Pfizer B2 mRNA, and AZ adenovirus are not well tolerated by a large margin compared to Pfizer B2. Immunogenicity for B2 is greater or equal to Moderna, AZ, and old Pfizer B1. Current Pfizer B2 dose is 30mcg IM x 2 doses 19-23d apart.
Evidence is still out on HCQ as prophylaxis as no proper study has been performed nor is it likely to happen. I've been on HCQ prophylaxis for 6 months, since March. Maybe it does something good, maybe it doesn't. But it does no harm. I've seen hundreds of people specific to COVID, live in L.A., traveled 5x on commercial flights to other areas since March and I have not contracted COVID. To qualify, for all you academic shits who somehow believe I don't understand that this is proof of nothing despite the fact that I do this for a living while you have zero experience, go fuck yourself.
If you have legitimate questions about the vaccine I will be happy to entertain. If you are a moronic anti vaxxer same applies to you as these academics, go fuck yourself. We were at 28.500 subjects today study wide with an initial 30k subjects. But a little greater than 80% are white people which the FDA does not find acceptable. Today they decided to expand to 44k subjects due to this issue, closing sites with little to zero Hispanic and black access in favor of sites like us in L.A. who agree not to see any more white people starting next week. This will slow things down considerably as these populations are simply not responsive due to what can only be described as ignorance despite the fact that they are in the greatest need. They believe crazy shit like they believe Church's fried chicken makes black men sterile and other equally unbelievable beliefs. In non-Hispanic caucasions, there has been an overwhelming response that I honestly didn't expect. There are literally hundreds of people I will not be able to schedule as we struggle to enroll Hispanics and AAs.
Rex.