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- Jul 16, 2018
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Johnson & Johnson recently announced that the company has stopped a clinical trial of a new Alzheimer's disease drug due to certain safety issues. This is like many large clinical trials have announced that there is no cure for Alzheimer's disease. Another failed clinical trial of the effect. More and more failure cases tell us that we need to stop and think about whether we have found the cause of Alzheimer's disease.
In the first analysis of the disease, doctor Alois Alzheimer from Germany found that some strange changes occurred in the brain of patients who died of this disease. He did not find two types of protein accumulation in the brains of young people. which is plaques existing between brain cells and tangles inside brain cells.
Studies have shown that individuals with risk factors for Alzheimer's disease, one of which is type 2 diabetes, it is clear that diabetes and Alzheimer's disease are very different, so what is the relationship between the two?
In diabetic patients,Insulin does not effectively control the body's blood sugar levels, but insulin not only controls blood sugar, it also functions as a growth factor, neuronal cells are dependent on growth factors, and if sufficient growth factors are not available, neuronal cells Will die.
The lack of effects of insulin growth factors in the brain seems to make neuronal cells sensitive to stress and also reduce the brain's ability to repair neurons. When the researchers analyzed brain tissue from patients with deceased Alzheimer's disease, they found that the insulin in these patients had lost its role as a growth factor, even in some non-diabetic patients. Studies have shown that diabetes drugs may be an effective treatment for patients with Alzheimer's disease, and in some clinical trials researchers have also made some impressive research results in animal experiments.
Observing any protective effects in the brain of a patient in a clinical trial may be a completely new result, and it also supports a new research theory that the onset of Alzheimer's disease and Parkinson's disease is partly due to The lack of growth factor activity in the brain of the patient; these new theories may help researchers to clarify the molecular mechanisms underlying the disease, and also help researchers develop effective treatments for Parkinson's disease and Alzheimer's disease.
I hope this sharing is useful to all of you guys,if you are not interested in that,sorry for wasting your time.
In the first analysis of the disease, doctor Alois Alzheimer from Germany found that some strange changes occurred in the brain of patients who died of this disease. He did not find two types of protein accumulation in the brains of young people. which is plaques existing between brain cells and tangles inside brain cells.
Studies have shown that individuals with risk factors for Alzheimer's disease, one of which is type 2 diabetes, it is clear that diabetes and Alzheimer's disease are very different, so what is the relationship between the two?
In diabetic patients,Insulin does not effectively control the body's blood sugar levels, but insulin not only controls blood sugar, it also functions as a growth factor, neuronal cells are dependent on growth factors, and if sufficient growth factors are not available, neuronal cells Will die.
The lack of effects of insulin growth factors in the brain seems to make neuronal cells sensitive to stress and also reduce the brain's ability to repair neurons. When the researchers analyzed brain tissue from patients with deceased Alzheimer's disease, they found that the insulin in these patients had lost its role as a growth factor, even in some non-diabetic patients. Studies have shown that diabetes drugs may be an effective treatment for patients with Alzheimer's disease, and in some clinical trials researchers have also made some impressive research results in animal experiments.
Observing any protective effects in the brain of a patient in a clinical trial may be a completely new result, and it also supports a new research theory that the onset of Alzheimer's disease and Parkinson's disease is partly due to The lack of growth factor activity in the brain of the patient; these new theories may help researchers to clarify the molecular mechanisms underlying the disease, and also help researchers develop effective treatments for Parkinson's disease and Alzheimer's disease.
I hope this sharing is useful to all of you guys,if you are not interested in that,sorry for wasting your time.