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True but negligible.
Ephedrine HCl is approximately 82% ephedrine by weight.
Ephedrine sulfate is approximately 77% ephedrine by weight.
25 mg ephedrine HCl = 20.5 mg ephedrine
25 mg ephedrine sulfate = 19.25 mg ephedrine
Duchaine used to say the sulfate is easier to assimilate. I think he was thinking of the size of the HCL crystals when to compared to SO4. Which is not an issue in modern drug manufacturing. For all practical purposes they are identical.
Great info on ECA. Run a google I'm sure you can find something comparable.