Estrogen mimics in our everyday life.

[wostok]

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There are so many chemicals out there that are mimics of the female sex hormone estrogen and are endocrine distruptors (i.e screw with hormone production) and are being injested (by leaching into foods) or absorbed by the skin (cosmetics for instance). It's no wonder blokes are growing tits, have declining sperm counts and mobility and are becoming infertile. Whilst females are suffering increasing rates of feminine cancers - breast, cervix etc. Exposure to these chemicals as a male foetus interferes with development of masculine features and brain function and causes genital and sperm abnormalities.

It's all quite handy dandy for the PTB, 2 birds with one stone - they cause infertility and declineing birth rates and deaths from cancers.

These commonly used and injested chems are all estrogen mimics -Pthalates (plastics, detergants), Bisphenols (plastics), PBDEs (fire retrardents used everywhere), Parabens (cosmetics, sun creams), carbon chlorines (pestisides), dixons (paper processing, herbicides) and loads more....



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Recent studies show sperm counts down by as much as half in parts of Europe. The quality of sperm is also declining.

Scientists are calling for more urgent study to determine whether problems are arising from specific chemicals or general contamination, and what role lifestyle plays.

Uncontrolled chemical doses affect more than the human life cycle, with some fish found to have both testes and ovaries.

Millions of tons of the affecting chemicals are manufactured every year



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Syracuse University biologists, in an experiment, gave injections of DDT [estrogen mimic] to baby roosters. The roosters grew up looking like hens. Unfortunately, the U.S. still produces 96 tons of DDT a year (in 1991) and exports it to third world countries. Then we consume DDT on imported produce. DDT is stored in the fat, notably the breast fat. The breast fat may concentrate a form of DDT up to 700 times than that of the blood. Blood levels of a form of DDT can typically be measured in the blood at several parts to tens of parts per billion.



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Gender-bending chemicals that mimic the effect of oestrogen are common in sunscreens, warns a team of Swiss researchers who have found that they trigger developmental abnormalities in rats...

4-MBC and other sunscreen chemicals have been shown to accumulate in fish from lakes where people swim. More worryingly, they have been found in breast milk at levels of nanograms per kilogram of fat - about the same as other known environmental contaminants



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In the past 50 years, the incidence of breast cancer has doubled, the rate of prostate cancer has doubled, and the rate of testicular cancer has tripled. More and more research is showing that toxins and chemicals in the environment are contributing to this increase in cancer and other diseases. Scientists estimate that each person today has at least 700 contaminants in their body. We live in a chemically contaminated world today!...

Xenoestrogens are man made substances that originate outside of the body and mimic the chemical structure of natural estrogen. Xeno means foreign, so xenoestrogens mean foreign estrogens. These synthetic environmental estrogens have been increasing in our water, air and food supply and can be found in pesticides, plastics, detergents, lacquers, body care products and other materials...

Estrogen is a growth hormone. One of the functions of estrogen is to stimulate cell proliferation in the breast and reproductive organs. In a healthy woman, estrogen ebbs and flows as needed throughout life until menopause when it tapers off. When this cycle is interrupted by stimulating increased cell division, such as with xenoestrogens, problems occur. The amount of estrogen a person is exposed to in their lifetime is one of the most significant risks of developing breast cancer.


Lots of articles about these types of chemicals
http://www.google.co.uk/search?hl=en&q=chemicals+mimic+estrogen&btnG=Google+Search&meta=&aq=f&oq=

 

[thebrick]

Interesting...

My wife works at a children's hospital and she told me a couple of weeks ago that they are now seeing girls as young as 8 years old starting puberty. The doctors suspect hormones added to our food. Things that make you go… hmmmm.

 

[Macro]

My wife works at a children's hospital and she told me a couple of weeks ago that they are now seeing girls as young as 8 years old starting puberty. The doctors suspect hormones added to our food. Things that make you go… hmmmm.

this is generally more due to higher rates of childhood obesity, though hormones in environment and food supply are a factor.

a more simple article on the estrogen adiposity connection (though less oriented towards dealing with exogenous factors- primarily that is avoidance)

The Anafit E-Zine Newsletter Ed1.vol3
The Estrogen Series: Part I
Estrogen and Adiposity: the Vicious Cycle

Estrogen is a necessary hormone but in excess it causes a host of issues. In this series of articles we will look at how excess estrogen and estrogenic compounds cause problems and what can be done about it.

Estrogen and Fat

The link between estrogen and body fat is circular. As body fat increases so does production of the aromatase enzyme; the enzyme that converts other hormones to estrogens. Increased production of the aromatase enzyme increases the amount of estrogen produced. As levels of estrogen increase, the amount of fat stored increases and the body’s ability to burn those fats decreases. This relationship leads to large stores of fat that are difficult to burn and produce more of the estrogen producing aromatase enzyme, which sustains the high levels of estrogen. Breaking the vicious cycle of high estrogen and body fat, even with exercise and diet, often proves to be difficult without directly addressing the cause and impact of high estrogen.
Subcutaneous or peripheral body fat, also referred to as gynoid or female pattern fat, is a heavy producer of the aromatase enzyme. Areas where this type of fat is most prevalent are hips, chest, thighs, lower back and triceps. It is important for the purposes of this discussion to differentiate between estrogenic fat and androgenic fat stores. Androgenic fat stores are intra-abdominal (inside the belly) and these type of fat stores are almost devoid of the production of aromatase enzyme.

The aromatase enzyme, as mentioned above, converts other hormones to estrogens. It converts androstenedione, which is also a precursor to testosterone, to the weak estrogen metabolite estrone. Aromatase enzyme also converts the weak estrone and testosterone to the potent estrogen estradiol. This is significant because excess aromatase enzyme not only increases total conversion to estrogens, but it significantly increases the production of the stronger estrogen metabolite estradiol. Having more of the strong estrogen metabolite is highly linked to various “female” cancers, heart disease, prostate cancer and other health issues so this is not a good thing. These problems are all in addition to the negative impact that extra estradiol has on fat storage. In men, excess aromatase enzyme and subsequent estrogen production leads to the emergence of a female fat pattern as well as possible gynecomastia. Also, because more estradiol is being produced it enhances the negative feedback on testosterone production, not only making a man more female but less male. In women, aside from the very apparent fat storage issues, the increases in estradiol over estrone means more of the negative health effects like the various cancers and heart disease that are linked to strong estrogenic signaling. Basically this means less estrone, which is the relatively beneficial weak estrogen, and more estradiol which is the strong and relatively harmful estrogen.

Estrogens direct impact on body fat is primarily through the regulation of adrenoceptors. Estrogens, and estradiol in particular, upregulate the alpha2 adrenoceptors and also down regulate beta adrenoceptor activity. In the simplest terms when it comes to body fat and its utilization for energy (fat burning), the beta adrenoceptors are the gas pedals and the alpha 2 receptors are the brakes. Estrogen, in those terms, enhances the brake pedal and weakens that gas pedal on your fat burning. In the race to lose fat or stop from gaining it, high estrogen puts you in the slow lane at best.

There are three primary methods of interrupting or diminishing the effects of this cycle of estrogen, body fat and the aromatase enzyme.

The first is to lose body fat through exercise and diet.
The second is to block the alpha adrenoceptors with alpha adrenoceptor blocker like yohimbine.
The third is to inhibit the aromatase enzyme either by blocking its synthesis, “destroying/using it up” with a suicidal aromatase enzyme inhibitor or by inhibiting its activity competitively with a competitive aromatase enzyme inhibitor.

You have probably heard it a hundred times, and you are going to hear it again. In order to lose body fat you need a calorie deficit, eating fewer calories than you use. This usually means some kind of calorie restriction (aka. diet) and exercise program. Blocking the Alpha 2 adrenoceptor, while employing a calorie deficit, will significantly facilitate fat loss from estrogenic fat areas. By blocking the Alpha 2 you basically take the foot off the brakes, this will also allow the beta adrenoceptors to be more active so it’s a bit of extra foot on the gas pedal too. A topical yohimbine product like Yohimburn is really the best option because it delivers a high dosage of the blocking agent directly to the tissues that need it. Yohimburn delivers yohimbine to the tissue directly. Oral yohimbine just cannot achieve the tissue concentrations needed without causing significant side effects.

Inhibiting the aromatase enzyme will take care of the estrogen production issue and will help with fat loss as well. At the time of this writing use of such inhibitors is only recommended in men, who will receive the added benefit of increased testosterone levels by inhibiting aromatase enzyme. Most aromatase enzyme inhibitors are prescription only. However, some over-the-counter products like AIFM have proven to be as effective as prescription aromatase enzyme inhibitors like aromasin. AIFM uses a natural suicidal aromatase enzyme inhibitor to “destroy”/inhibit the aromatase enzyme.

Excess estrogen production presents many issues, but there are means and tools to help combat this threat

 

[kfrost06]

estrogens are everywhere in fact some companies actually add estrogens to their products. A lot of black female cosmetic products have estrogens added and are causing early puberty in girls, I can only imagine what it would do to a guy

 

[Trenman]

This is the reason almost all men have a below normal testosterone level. Normal, BTW, is 750 to 1200ng/dl. (26 to 41.6nmol/L) Not the 240 to 800ng/dl nonsense we are being forced to live by.

 

[rocket]

If you use something like Yohimbine, then wont the alpha-2 adrenergic receptors up regulate in response to the inhibition and ultimately make things worse in the long run?

 

[Macro]

If you use something like Yohimbine, then wont the alpha-2 adrenergic receptors up regulate in response to the inhibition and ultimately make things worse in the long run?

no, actually the opposite (at least to some extent-- more so if fat loss is sufficient for apoptosis)