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Exemestane while off cycle

Macdaddy

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Jun 13, 2002
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Does anyone use an anti-e while off cycle to maximize free test. I was thinking that a product like Exemestane would be a good fit since it inhibits aromatization which would increase free test which would allow you to keep more gains while off cycle.

Does anyone see any issues with this? Also, would this not be beneficial to natural BBers? This would be a good way to increase free test without actually taking any AAS.
 

juicin

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Sep 30, 2005
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Does anyone use an anti-e while off cycle to maximize free test. I was thinking that a product like Exemestane would be a good fit since it inhibits aromatization which would increase free test which would allow you to keep more gains while off cycle.

Does anyone see any issues with this? Also, would this not be beneficial to natural BBers? This would be a good way to increase free test without actually taking any AAS.
the doses used would probably have to be very very small if using when not on AAS to be beneficial.

Actually it probably wouldnt be beneficial at all, your body needs estrogen to function properly. Sex drive, joints, healthy cholesterol levels... etc..
 

Macdaddy

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Thats true, but Exemestane is only approx. 65 - 80% effective at inhibiting aromatization. I have read that you really only need a VERY small amount of estrogen to keep everything functioning normally.

I guess the question is, how little estrogen can you get away with and how much Exemestane would you need to get there, assuming you are not on any AAS.
 

Tom

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interesting study on letro

Letrozole once a week normalizes serum testosterone in obesity-related male hypogonadism
Sandra Loves1, Janneke Ruinemans-Koerts2 and Hans de Boer1
Departments of1 , Internal Medicine2 Clinical Chemistry, Ziekenhuis Rijnstate, Wagnerlaan 55, 6800 TA Arnhem, The Netherlands

(Correspondence should be addressed to H de Boer; Email: [email protected])

Objective: Isolated hypogonadotropic hypogonadism (IHH) is frequently observed in severely obese men, probably as a result of increased estradiol (E2) production and E2-mediated negative feedback on pituitary LH secretion. Aromatase inhibitors can reverse this process. This study evaluates whether letrozole once a week can normalize serum testosterone in severely obese men and maintain its long term effect.

Design: Open, uncontrolled 6-month pilot study in 12 severely obese men (body mass index>35.0 kg/m2) with obesity-related IHH and free testosterone levels <225 pmol/l, treated with 2.5 mg letrozole once a week for 6 months.

Results: Six weeks of treatment reduced total E2 from 123±11 to 58±7 pmol/l (P<0.001, mean±S.E.M.), and increased serum LH from 4.4±0.6 to 11.1±1.5 U/l (P<0.001). Total testosterone rose from 5.9±0.5 to 19.6±1.4 nmol/l (P<0.001), and free testosterone from 163±13 to 604±50 pmol/l (P<0.001). Total testosterone rose to within the normal range in all subjects, whereas free testosterone rose to supraphysiological levels in 7 out of 12 men. The testosterone and E2 levels were stable throughout the week and during the 6-month treatment period.

Conclusion: Letrozole 2.5 mg once a week produced a sustained normalization of serum total testosterone in obese men with IHH. However, free testosterone frequently rose to supraphysiological levels. Therefore, a starting dose <2.5 mg once a week is recommended.
 

PsyT

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it would work at low doses especially if you are having female fatty deposits (thighs and breasts).

I would think with your natural test you'd want to match a very small amount of aromasin...like 5mg ED maybe.
 

packing_it_on

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There was a thread on this not too long ago, but I can't find it right now.

The gist of it was that it's beneficial in very small doses while OFF. But only with Exemestane, as it's suicidal, and you wont get estrogen rebound. I believe it stated a quarter dose of 6.25mg ED, maximum. It also stated not to take it EOD, as it has a 27 hour half life, and you want to keep your levels as stable as possible.

-Pack
 

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