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Formastane as a bridge..

thewarrior23

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Jan 4, 2008
Messages
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I know formastane can raise test a little and do a good job a lower E2 levels, was wondering if you could use this as a good bridge between cycles, at 200mg ED will lower E2 and raise test w/o shutting you down.

My only question is just dont want to be on this stuff if it loses its effectiveness real quick. Came across 2 articles, 1st article makes it sound like this stuff will cont. to work for 8-14months and the 2nd articles seems to say it loses its effectiveness or at least part oafter 3 months, "but at the same time must consider this means its loseing effect. with cancer tumors not simple blocking xtra estro from AAS use.So I need help making sense of the articles. I also found info that shows it will cont. to raise estro for 22cont. weeks which the extra test comes from the anti-e effect i believe. BUt just wanting to know if you could use as a bridge (mild test increase and lower estro for 4 months bewtween cycles..??

Here are the articles...
Aromatase :: therapeutic use
Formestane (4-hydroxyandrostenedione) is an aromatase inhibitor which significantly reduces plasma levels of estrogen and has shown antitumour activity in postmenopausal women with breast cancer. Objective response rates in heavily pretreated patients with advanced breast cancer generally range between 20 and 30% during treatment with intramuscular formestone 250 or 500mg once every 2 weeks, and a further 20 to 30% of patients experience disease stabilisation. The median duration of response is between 8 and 14 months
http://www.ncbi.nlm.nih.gov/bookshel...d6&part=A16133
4-Hydroxyandrostenedione has also been given orally. Even though there is a marked first-pass effect with conversion in the liver to a glucuronidated derivative, oral doses of 250 mg reduce plasma estradiol by 53% and doses up to 1,000 mg produce no further suppression. The response rate after 3 months of therapy was 33%, and the only serious side effect from the oral dosage was leukopenia in a single patient.38


So after looking at the articles, do you think youd still get an ant-estro effect/increase in test if you were on it for 4 months between a cycle(bridge)????
 

PaulKersey

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May 30, 2010
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Four months seems like a long time. I ran the transdermal (CEL's) after a PH cycle (Superdrol) as part of my PCT and I'd swear it did help drop bf a bit among other things, but I don't know if I'd run it for 16 weeks. I 'felt' as if it was tapering off in terms of what it was doing by the end of the month, but that might have been in my head. Did keep most of the gains.

Yeah, these days I know Sdrol isn't really a PH.
 

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