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GHRP-2 to help Left Ventricular dysfuntion?

dece870717

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Joined
May 18, 2009
Messages
627
I was searching through pubmed as I often do for certain things and I came across an interesting article regarding GHRP-2 and LV dysfunction and as steroid users LV hypertrophy and the possible dysfunction of the enlarged LV, can become a problem later in life. I was intrigued by what this could do for those with any LV dysfunction. Hoping to get some thoughts from others on the matter...

Beneficial effects of growth hormone-releasing pep... [Circ J. 2010] - PubMed result

"Abstract

BACKGROUND: Growth hormone-releasing peptide (GHRP) may act directly on the myocardium and improve left ventricular (LV) function, suggesting a potential new approach to the treatment of cardiomyopathic hearts. The present study tested the hypothesis that the beneficial cardiac effects of GHRP might include attenuation of myocardial oxidative stress.

METHODS AND RESULTS: Dilated cardiomyopathic TO-2 hamsters were injected with GHRP-2 (1 mg/kg) or saline from 6 to 12 weeks of age. F1B hamsters served as controls. Untreated TO-2 hamsters progressively developed LV dilation, wall thinning, and systolic dysfunction between 6 and 12 weeks of age. Marked myocardial fibrosis was apparent in untreated hamsters at 12 weeks of age in comparison with F1B controls. The ratio of reduced to oxidized glutathione (GSH/GSSG) was decreased and the concentration of 4-hydroxynonenal (4-HNE) was increased in the hearts of untreated TO-2 hamsters. Treatment with GHRP-2 attenuated the progression of LV remodeling and dysfunction, as well as myocardial fibrosis, in TO-2 hamsters. GHRP-2 also inhibited both the decrease in the GSH/GSSG ratio and the increase in the concentration of 4-HNE in the hearts of TO-2 hamsters.

CONCLUSIONS: GHRP-2 can suppress the increase in the level of myocardial oxidative stress, leading to attenuation of progressive LV remodeling and dysfunction in dilated cardiomyopathic hamsters. (Circ J 2010; 74: 163 - 170)."
 

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