Upon returning home from even just a couple months in zero gravity, astronauts require extended periods of rehabilitation. Sometimes over a year or even more. Their eye pressure has changed, they need to regain bone density and muscle mass, balance, coordination. Even speech therapy as their tongue and lips now are weighted. A many months (over a year) trip to Mars and back would yield at least some people who are permanently unsuitable to return to normal life back here on Earth.
Travelling to Mars, while seemingly really cool, is a massive, massive boondoggle. Humans aren't going to spread throughout the galaxy like moving to new neighborhoods. The galaxy and the entire universe outside our Earthly environment is an entirely inhospitable environment to living things. So we get to Mars. Then what? Spend billions and billions to make this happen and then what? Are we going leave our solar system into deep space on a multi-generational space craft like Battlestar Galactica?
Rather than wasting valuable resources on a one-way trip to nowhere, why not use those resources to give this planet, our home, the ability to support more than two or three more generations before people start dying by the millions or billions? There is no planet B. We've been horrible stewards of our planet and now we want to take these fanciful ideas and attempt to leave our trash heap of a planet to create another trash heap somewhere else.
I suppose if nothing else, it's a befitting end to our existence as a species.