Gyno from primo?

finxster · Feb 10, 2024

I'm lost here. Any chance primo can cause gyno? I added 100mg to my TRT two weeks ago, and today noticed my nipples are puffy and sore. Took 1mg anastrozole that I keep on hand, and will get bloods run on Monday. Should I assume the primo is something different? Below is everything I take during TRT and have run only this for the past 6 weeks (primo for 2 weeks). Any help would be appreciated.

200 test (TRT from pharmacy)
100 primo (Guaranteed source from here)
~3iu GH (1/5 vial TPs Blacktops)
Probiotic
81mg aspirin
2.5mg finasteride
5mg cialis
Multivitamin
50mg Vitamin D

slesh · Feb 10, 2024

For most it would have the opposite effect. I hate to make a blanket statement about your source - but I would assume it’s not really Primo.

Hyperemia · Feb 10, 2024

Yeah I don't know what else is at play but you should not be getting an gyno symptoms from primo, it should have the opposite effect.

bbxtreme · Feb 10, 2024

Run e2, progesterone and prolactin. Get to the bottom of it as it’s much smarter than guesswork with AI issues IMO.

Cerberus777 · Feb 10, 2024

It could be your gh and finasteride get blood work done.

finxster · Feb 10, 2024

bbxtreme said:
Run e2, progesterone and prolactin. Get to the bottom of it as it’s much smarter than guesswork with AI issues IMO.

Thanks! Was going to just get E2.

finxster · Feb 10, 2024

Cerberus777 said:
It could be your gh and finasteride get blood work done.

I've been on both for months. How could adding the primo (or whatever compound it is) chane things?

Cerberus777 · Feb 10, 2024

Hormone balance is tricky. Low dht conversion can increase prolactin so can gh. You could be right at the point of having issues. Add something else to the mix. Could be just enough to offset hormones.

SOUR DIESEL · Feb 10, 2024

finxster said:
I'm lost here. Any chance primo can cause gyno?

^^^No

Cerberus777 said:
It could be your gh and finasteride get blood work done.

^^^ahhh-ha ..i think you'r onto something here brother ..lol

► these "solve-the-mystery's" are fun
..so lets look at OP's list here:

200 test (TRT from pharmacy)
100 primo (Guaranteed source from here)
~3iu GH (1/5 vial TPs Blacktops)
Probiotic
81mg aspirin
2.5mg finasteride
5mg cialis
Multivitamin
50mg Vitamin D

► IMO/ WHAT I SEE:
♦ you'r taking TEST
..yes the dose is low ..BUT enough to shout down any your own production
..i saw no AI in OP's regimen ..so you'r converting/making Estrogen
..at that LOW dose ..i would suspect that you are injecting that ONCE a WEEK
..this by itself will increase the amount of Estrogen that you will generate from a given dose of TEST
..excess Estrogen increases PROLACTIN
..excess Estrogen increases SHBG

^^^KEY POINTS HERE;
..there is nothing nothing restricting Estrogen creation
..your dosing schedule (..if once ..or even twice a week) promotes even more Estrogen
..this Estrogen is enough to shut down HPT-Axis

***NOTE: "IF" OP has a high(er) BF% ..then he will convert to Estrogen even more

♦ you'r taking PRIMO
..yes low dose ..BUT you'v ONLY been taking it 2weeks ..it has not saturated your system yet as it is ENANTHATE
..it's probably "..the other cc" in OP's once-a-week injection ..this 1x/wk-dosing will do nothing to shorten PRIMO's on-set time
..so "any" Estrogen-Lowering-Benefits that PRIMO may have provided ..even at OP's low dose ..are probably at least a few more weeks from being realized

^^^KEY POINTS HERE;
..PRIMO may very well be real
..PRIMO has not been used long enough to offer it's Estrogen mitigation (..2wks)

♦ you'r taking FINASTERIDE (..OP has been running "for months")
..yes dose is low ..BUT it's it's STILL enough to block a significant amount of DHT conversion (..doesn't take much)
..so the natural protection that DHT would have provided against Estrogen is gone, or greatly diminished
..FINA studies show that when you block DHT ..Estrogen increases/you convert more ESTROGEN (..if you block one exit ..more run to the other exit)
..DHT is also missing to protect/keep down PROLACTIN
..DHT is also missing to reduce SHBG ..& any DHT this is left present is very likely bound to SHBG ..as SHBG's highest affinity is for DHT
..i saw no CABER etc in OP's regimen

♦ you'r taking GH (..OP has been running "for months")
..decent dose ..esp as a replacement
..enough to create "some" excess/extra Prolactin ←esp when you'r missing DHT to help protect you here
..again i saw no CABER etc in OP's regimen

SO YOU HAVE;
-no natural TEST bc you'r taking EXO-TEST
-only taking 200mg of EXO-TEST
-no AI
-no DHT to antagonize Estrogen
-no DHT to antagonize PROLACTIN
-any "remaining" DHT is likely occupied by SHBG ..& therefore un-bio-available
-higher Estrogen Ratios ..or "un-opposed" Estrogen
-high(er) BF% contributing to increased Estrogen conversion (..more BF = more Aromatase)
-higher/un-opposed Estrogen & no/limited DHT leading to higher PROLACTIN levels
-GH also driving up PROLACTIN levels up

ESTROGEN + PROLACTIN + HIGH SHBG - DHT = GYNO mystery solved!!!!!

.

Cerberus777 · Feb 10, 2024

SOUR DIESEL said:
^^^No

^^^ahhh-ha ..i think you'r onto something here brother ..lol

► these "solve-the-mystery's" are fun
..so lets look at OP's list here:

200 test (TRT from pharmacy)
100 primo (Guaranteed source from here)
~3iu GH (1/5 vial TPs Blacktops)
Probiotic
81mg aspirin
2.5mg finasteride
5mg cialis
Multivitamin
50mg Vitamin D

► IMO/ WHAT I SEE:
♦ you'r taking TEST
..yes the dose is low ..BUT enough to shout down any your own production
..i saw no AI in OP's regimen ..so you'r converting/making Estrogen
..at that LOW dose ..i would suspect that you are injecting that ONCE a WEEK
..this by itself will increase the amount of Estrogen that you will generate from a given dose of TEST
..excess Estrogen increases PROLACTIN
..excess Estrogen increases SHBG

^^^KEY POINTS HERE;
..there is nothing nothing restricting Estrogen creation
..your dosing schedule (..if once ..or even twice a week) promotes even more Estrogen
..this Estrogen is enough to shut down HPT-Axis

***NOTE: "IF" OP has a high(er) BF% ..then he will convert to Estrogen even more

♦ you'r taking PRIMO
..yes low dose ..BUT you'v ONLY been taking it 2weeks ..it has not saturated your system yet as it is ENANTHATE
..it's probably "..the other cc" in OP's once-a-week injection ..this 1x/wk-dosing will do nothing to shorten PRIMO's on-set time
..so "any" Estrogen-Lowering-Benefits that PRIMO may have provided ..even at OP's low dose ..are probably at least a few more weeks from being realized

^^^KEY POINTS HERE;
..PRIMO may very well be real
..PRIMO has not been used long enough to offer it's Estrogen mitigation (..2wks)

♦ you'r taking FINASTERIDE (..OP has been running "for months")
..yes dose is low ..BUT it's it's STILL enough to block a significant amount of DHT conversion (..doesn't take much)
..so the natural protection that DHT would have provided against Estrogen is gone, or greatly diminished
..FINA studies show that when you block DHT ..Estrogen increases/you convert more ESTROGEN (..if you block one exit ..more run to the other exit)
..DHT is also missing to protect/keep down PROLACTIN
..DHT is also missing to reduce SHBG ..& any DHT this is left present is very likely bound to SHBG ..as SHBG's highest affinity is for DHT
..i saw no CABER etc in OP's regimen

♦ you'r taking GH (..OP has been running "for months")
..decent dose ..esp as a replacement
..enough to create "some" excess/extra Prolactin ←esp when you'r missing DHT to help protect you here
..again i saw no CABER etc in OP's regimen

SO YOU HAVE;
-no natural TEST bc you'r taking EXO-TEST
-only taking 200mg of EXO-TEST
-no AI
-no DHT to antagonize Estrogen
-no DHT to antagonize PROLACTIN
-any "remaining" DHT is likely occupied by SHBG ..& therefore un-bio-available
-higher Estrogen Ratios ..or "un-opposed" Estrogen
-high(er) BF% contributing to increased Estrogen conversion (..more BF = more Aromatase)
-higher/un-opposed Estrogen & no/limited DHT leading to higher PROLACTIN levels
-GH also driving up PROLACTIN levels up

ESTROGEN + PROLACTIN + HIGH SHBG - DHT = GYNO mystery solved!!!!!

.

No long enough to lower estrogen but long enough to lower SHBG

td · Feb 10, 2024

I've had issues. Primo drove my prolactin high, exacerbating gyno symptoms.

I was only on testosterone and primo. I have bloodwork that confirms low estrogen, high prolactin.

finxster · Feb 10, 2024

SOUR DIESEL said:
^^^No

^^^ahhh-ha ..i think you'r onto something here brother ..lol

► these "solve-the-mystery's" are fun
..so lets look at OP's list here:

200 test (TRT from pharmacy)
100 primo (Guaranteed source from here)
~3iu GH (1/5 vial TPs Blacktops)
Probiotic
81mg aspirin
2.5mg finasteride
5mg cialis
Multivitamin
50mg Vitamin D

► IMO/ WHAT I SEE:
♦ you'r taking TEST
..yes the dose is low ..BUT enough to shout down any your own production
..i saw no AI in OP's regimen ..so you'r converting/making Estrogen
..at that LOW dose ..i would suspect that you are injecting that ONCE a WEEK
..this by itself will increase the amount of Estrogen that you will generate from a given dose of TEST
..excess Estrogen increases PROLACTIN
..excess Estrogen increases SHBG

^^^KEY POINTS HERE;
..there is nothing nothing restricting Estrogen creation
..your dosing schedule (..if once ..or even twice a week) promotes even more Estrogen
..this Estrogen is enough to shut down HPT-Axis

***NOTE: "IF" OP has a high(er) BF% ..then he will convert to Estrogen even more

♦ you'r taking PRIMO
..yes low dose ..BUT you'v ONLY been taking it 2weeks ..it has not saturated your system yet as it is ENANTHATE
..it's probably "..the other cc" in OP's once-a-week injection ..this 1x/wk-dosing will do nothing to shorten PRIMO's on-set time
..so "any" Estrogen-Lowering-Benefits that PRIMO may have provided ..even at OP's low dose ..are probably at least a few more weeks from being realized

^^^KEY POINTS HERE;
..PRIMO may very well be real
..PRIMO has not been used long enough to offer it's Estrogen mitigation (..2wks)

♦ you'r taking FINASTERIDE (..OP has been running "for months")
..yes dose is low ..BUT it's it's STILL enough to block a significant amount of DHT conversion (..doesn't take much)
..so the natural protection that DHT would have provided against Estrogen is gone, or greatly diminished
..FINA studies show that when you block DHT ..Estrogen increases/you convert more ESTROGEN (..if you block one exit ..more run to the other exit)
..DHT is also missing to protect/keep down PROLACTIN
..DHT is also missing to reduce SHBG ..& any DHT this is left present is very likely bound to SHBG ..as SHBG's highest affinity is for DHT
..i saw no CABER etc in OP's regimen

♦ you'r taking GH (..OP has been running "for months")
..decent dose ..esp as a replacement
..enough to create "some" excess/extra Prolactin ←esp when you'r missing DHT to help protect you here
..again i saw no CABER etc in OP's regimen

SO YOU HAVE;
-no natural TEST bc you'r taking EXO-TEST
-only taking 200mg of EXO-TEST
-no AI
-no DHT to antagonize Estrogen
-no DHT to antagonize PROLACTIN
-any "remaining" DHT is likely occupied by SHBG ..& therefore un-bio-available
-higher Estrogen Ratios ..or "un-opposed" Estrogen
-high(er) BF% contributing to increased Estrogen conversion (..more BF = more Aromatase)
-higher/un-opposed Estrogen & no/limited DHT leading to higher PROLACTIN levels
-GH also driving up PROLACTIN levels up

ESTROGEN + PROLACTIN + HIGH SHBG - DHT = GYNO mystery solved!!!!!

.

Thank you! Wonderful breakdown. Needed another perspective. I was only paying attention to what I added.

Bloodwork will be done Monday. I'll go ahead and drop the finasteride. Already took some anastrozole and will keep that going. I've never needed an AI for 200 test because my estrogen is just a touch high in the 50s and no sides.

I should have paid attention to my body because I actually noticed my hair shedding this week. I feel stupid for ignoring it.

VaginaBoob89 · Feb 10, 2024

finxster said:
I've been on both for months. How could adding the primo (or whatever compound it is) chane things?

have you added significant bodyweight/fat?

specter · Feb 10, 2024

Just take a short look at the inserts of all the stuff your taking, like half of it can cause gyno...

bbxtreme · Feb 10, 2024

finxster said:
Thanks! Was going to just get E2.

So many guys just do that. It’s easy and common. But I’ve seen guys with 20-40 e2 and still have prolactin and progesterone issues. Always run all three when looking at AI stuff.

finxster · Feb 10, 2024

VaginaBoob89 said:
have you added significant bodyweight/fat?

Nope. I always drop some weight after cycle, during my TRT. I intentionally dial the food back so that doesn't happen.

madg · Feb 10, 2024

Is not primo

Sry i not care where you got it

Im on primo 10 year and no chance to give you gyno if legit

Maybe is cut with tren or npp

Send it for testing if you can

Zamun · Feb 10, 2024

madg said:
Is not primo

Sry i not care where you got it

Im on primo 10 year and no chance to give you gyno if legit

Maybe is cut with tren or npp

Send it for testing if you can

You’ve been on primo for 10 years?

what dosages?

gains4000 · Feb 10, 2024

Finasteride is an anti-androgen. DHT is a key factor at preventing gynecomastia. I would drop the finasteride and add 20mg Nolvadex everyday. Drop the Nolvadex when you feel better. Primo is a strong anti estrogen - it is like saying Arimidex can cause gyno.