Gyno from primo?

[Zamun]

Yes

150 test - gh for criuise 6-8 weeks
Test + primo+ gh for blast

Have gone up to 1000 mg ew

Have used bayer rimobolan and countless ugs

okay so not cruising on primo

 

[madg]

okay so not cruising on primo

No is not cruise if other aas in but that just me

 

[SOUR DIESEL]

No long enough to lower estrogen but long enough to lower SHBG

^^^hey brother ..i think that you are referencing my comment about PRIMO??

^^^& one might think this is true bc after all it's a DHT-derivative, right??


► but i'v been saying for a long time that;
..just bc something is a DHT-derivative does NOT mean that it shares DHT's binding ability ..or affinity for certain tissues

→ this is the case with PRIMO according to it's pharmacology

" Pharmacokinetics;
Metenolone has very low affinity for human serum sex hormone-binding globulin (SHBG), about 16% of that of testosterone and 3% of that of DHT. "


REF:

1. Saartok T, Dahlberg E, Gustafsson JA (June 1984). "Relative binding affinity of anabolic-androgenic steroids: comparison of the binding to the androgen receptors in skeletal muscle and in prostate, as well as to sex hormone-binding globulin". Endocrinology. 114 (6): 2100–2106. doi:10.1210/endo-114-6-2100. PMID 6539197.

^^^there are other AAS-DHT-Derivatives that have been "bro-sci'd" to do the same ..but actually don't
..WINSTROL comes to mind;
..it has VERY low affinity for SHBG ..only 5% that of TEST ..& only 1% that of DHT
(..same REF as noted above for PRIMO)


→ FYI; the AAS/PED with the highest SHBG binding is PROV


.

 

[Oldwhitedude]

Primo never lowered estrogen for me just FYI.

Doesn't appear to do that for everyone.

 

[gains4000]

Primo never lowered estrogen for me just FYI.

Doesn't appear to do that for everyone.

It’s still an anti-estrogen like masteron. Just because a drug isn’t lowering estrogen production doesn’t mean it’s not antagonizing estrogen at the ER. For many primo and boldenone bind to aromatase enzymes.

 

[Cerberus777]

^^^hey brother ..i think that you are referencing my comment about PRIMO??

^^^& one might think this is true bc after all it's a DHT-derivative, right??


► but i'v been saying for a long time that;
..just bc something is a DHT-derivative does NOT mean that it shares DHT's binding ability ..or affinity for certain tissues

→ this is the case with PRIMO according to it's pharmacology

" Pharmacokinetics;
Metenolone has very low affinity for human serum sex hormone-binding globulin (SHBG), about 16% of that of testosterone and 3% of that of DHT. "


REF:

1. Saartok T, Dahlberg E, Gustafsson JA (June 1984). "Relative binding affinity of anabolic-androgenic steroids: comparison of the binding to the androgen receptors in skeletal muscle and in prostate, as well as to sex hormone-binding globulin". Endocrinology. 114 (6): 2100–2106. doi:10.1210/endo-114-6-2100. PMID 6539197.

^^^there are other AAS-DHT-Derivatives that have been "bro-sci'd" to do the same ..but actually don't
..WINSTROL comes to mind;
..it has VERY low affinity for SHBG ..only 5% that of TEST ..& only 1% that of DHT
(..same REF as noted above for PRIMO)


→ FYI; the AAS/PED with the highest SHBG binding is PROV


.

Yeah, piggy backing what you were saying. Primo acts heavily like a DHT on SHBG but it's not a heavily on other DHT receptors so it can mess with prolactin. And the first few weeks free estrogen is higher due to lower SHBG. The problem is that if heavy AI use is employed and the Primo acts as an AI it will then crush estrogen in a few weeks.

That's why I said the balance is tricky. I'd drop the finasteride personally and get a blood test to see if Caber is needed.

 

[Alzadosghost]

Primo never lowered estrogen for me just FYI.

Doesn't appear to do that for everyone.

How much were you using and for how long?

 

[madg]

Primo never lowered estrogen for me just FYI.

Doesn't appear to do that for everyone.

Same doenst lower estro for me too

But giving gyno ????? No fkin way

 

[specter]

Same doenst lower estro for me too

But giving gyno ????? No fkin way

And how exactly do we know its the primo giving him gyno ? the man is using like 10 meds ?

 

[madg]

And how exactly do we know its the primo giving him gyno ? the man is using like 10 meds ?

He said everything started when he added the primo

 

[Cerberus777]

He said everything started when he added the primo

Primo most likely is the catalus not the cause. He needs blood work. I'm willing to give an educated guess if I saw blood work...but to many variables to throw the kitchen sink at it.

 

[madg]

Primo most likely is the catalus not the cause. He needs blood work. I'm willing to give an educated guess if I saw blood work...but to many variables to throw the kitchen sink at it.

Agree and sry but im not english so maybe sometimes i not get through what i mean

On other hand is very usual for primo to be fake , wouldnt be surprised if is cut with tren or npp

But yes always bw first

 

[specter]

Agree and sry but im not english so maybe sometimes i not get through what i mean

On other hand is very usual for primo to be fake , wouldnt be surprised if is cut with tren or npp

But yes always bw first

The primo is from a source on this page and since he writes guaranted im guessing its been tested. Ppl get gyno all the time from different things

 

[Cerberus777]

Agree and sry but im not english so maybe sometimes i not get through what i mean

On other hand is very usual for primo to be fake , wouldnt be surprised if is cut with tren or npp

But yes always bw first

I would wager its really primo, but hormone feedback loops are off like I and @SOUR DIESEL said

 

[Xplicit]

I have had something similar to this happen before. No test. Just primo, and yes it was real.

Its not the primo giving gyno necessarily, the same thing happens to me now if I lower my testosterone too low and take EQ (my existing gyno will get sore and feel flared up but no actual growth occurs). Even without seeing bloods (and not saying its 100% low e2) I am willing to bet if you doubled or tripled your testosterone dose alongside that dose of primo, this would stop the gyno symptoms. There's an imbalance occurring somewhere.

 

[musclehngry]

^^^No


^^^ahhh-ha ..i think you'r onto something here brother ..lol



► these "solve-the-mystery's" are fun
..so lets look at OP's list here:

200 test (TRT from pharmacy)
100 primo (Guaranteed source from here)
~3iu GH (1/5 vial TPs Blacktops)
Probiotic
81mg aspirin
2.5mg finasteride
5mg cialis
Multivitamin
50mg Vitamin D


► IMO/ WHAT I SEE:
♦ you'r taking TEST
..yes the dose is low ..BUT enough to shout down any your own production
..i saw no AI in OP's regimen ..so you'r converting/making Estrogen
..at that LOW dose ..i would suspect that you are injecting that ONCE a WEEK
..this by itself will increase the amount of Estrogen that you will generate from a given dose of TEST
..excess Estrogen increases PROLACTIN
..excess Estrogen increases SHBG

^^^KEY POINTS HERE;
..there is nothing nothing restricting Estrogen creation
..your dosing schedule (..if once ..or even twice a week) promotes even more Estrogen
..this Estrogen is enough to shut down HPT-Axis

***NOTE: "IF" OP has a high(er) BF% ..then he will convert to Estrogen even more


♦ you'r taking PRIMO
..yes low dose ..BUT you'v ONLY been taking it 2weeks ..it has not saturated your system yet as it is ENANTHATE
..it's probably "..the other cc" in OP's once-a-week injection ..this 1x/wk-dosing will do nothing to shorten PRIMO's on-set time
..so "any" Estrogen-Lowering-Benefits that PRIMO may have provided ..even at OP's low dose ..are probably at least a few more weeks from being realized

^^^KEY POINTS HERE;
..PRIMO may very well be real
..PRIMO has not been used long enough to offer it's Estrogen mitigation (..2wks)


♦ you'r taking FINASTERIDE (..OP has been running "for months")
..yes dose is low ..BUT it's it's STILL enough to block a significant amount of DHT conversion (..doesn't take much)
..so the natural protection that DHT would have provided against Estrogen is gone, or greatly diminished
..FINA studies show that when you block DHT ..Estrogen increases/you convert more ESTROGEN (..if you block one exit ..more run to the other exit)
..DHT is also missing to protect/keep down PROLACTIN
..DHT is also missing to reduce SHBG ..& any DHT this is left present is very likely bound to SHBG ..as SHBG's highest affinity is for DHT
..i saw no CABER etc in OP's regimen


♦ you'r taking GH (..OP has been running "for months")
..decent dose ..esp as a replacement
..enough to create "some" excess/extra Prolactin ←esp when you'r missing DHT to help protect you here
..again i saw no CABER etc in OP's regimen


SO YOU HAVE;
-no natural TEST bc you'r taking EXO-TEST
-only taking 200mg of EXO-TEST
-no AI
-no DHT to antagonize Estrogen
-no DHT to antagonize PROLACTIN
-any "remaining" DHT is likely occupied by SHBG ..& therefore un-bio-available
-higher Estrogen Ratios ..or "un-opposed" Estrogen
-high(er) BF% contributing to increased Estrogen conversion (..more BF = more Aromatase)
-higher/un-opposed Estrogen & no/limited DHT leading to higher PROLACTIN levels
-GH also driving up PROLACTIN levels up




ESTROGEN + PROLACTIN + HIGH SHBG - DHT = GYNO mystery solved!!!!!


.

Thank you for the detailed explanation, very interesting.

 

[Green Miles]

Only if your nandrlone was "accidentally" labeled as primo!!!

 

[LK3]

pretty sure there is such a thing as igf induced gyno.

 

[finxster]

Just a followup to close this out. E2 was through the roof at 98.

I dropped the finasteride and took 1mg Adex daily until the lumps and nipple sensitivity went away. Continued with TRT and got good bloodwork 2 weeks ago so am now starting my next blast.

Thanks for the help guys.