The only issue I see with berberine is something Stewie told me to be careful about/aware of before suggesting a family member start using berberine..
"I'd be careful with Berberine if he's on anything that's a prescription thats substrate of CYP2D6 or 3A4. Which a lot of drugs are metabolized through those pathways."
"Repeated administration of berberine (300 mg, t.i.d., p.o.) decreased CYP2D6, 2C9, and CYP3A4 activities. Drug-drug interactions should be considered when berberine is administered."
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Would you happen to know if metformin has the same negative drug interactions as berberine?