New Drug Offers Hope for CPAP-Free Nights for Sleep Apnea

[hawkmoon]

New Drug Offers Hope for CPAP-Free Nights for Sleep Apnea​

An interesting option for some of us who are perhaps less seriously impacted


Could there be a new approach — a simple pill — that eases sleep apnea symptoms and replaces more conventional treatments?

That's what researchers at Apnimed hope. Apnimed is a company that's developed a new oral drug for sleep apnea — currently called AD109. AD109 combines the drugs aroxybutynin and atomoxetine.

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Kuhlmann said there are two big things they noticed: The apnea-hypopnea index dropped in patients given two different doses of the drug. Those in the group that took the lower dosage actually saw "clinically significant improvement in fatigue."

For those with an index score of 10-15 (mild), 77% had their scores lowered to below 10.

But only 42% with a score of 15-30 (moderate) were able to get below 10. And only 7% of those with a score of over 30 were able to get all the way down to 10 or below.

Regarding some of the index score drops, Kuhlmann said, "If you drop from an AHI of 20-10, that's still OSA [obstructive sleep apnea] if you have diabetes, high blood pressure, depression, daytime sleepiness, or insomnia."

 

[bbxtreme]

A bladder relaxant and a cognition drug for ADD and ADHD combined sounds like an interesting mix.

I think I personally would stick to my CPAP over mixing these meds. But I'm always fascinated to follow the research of items as they undergo testing.

 

[Fa Seeshus]

A bladder relaxant and a cognition drug for ADD and ADHD combined sounds like an interesting mix.

I think I personally would stick to my CPAP over mixing these meds. But I'm always fascinated to follow the research of items as they undergo testing.

Bro, I'm on this stuff and it is amazing. When I piss it is like a sniper hose and I totally murder those blue urinal cakes. I'm surgical with this weiner I tell you.

Didn't know it was supposed to help with sleep. My doctor just marketed it as "dick laser."

 

[UnholyAlliance]

I'd see using this for something like for flying on a business trip where you don't have to bring an annoying cpap machine on the plane.

 

[hawkmoon]

I'd see using this for something like for flying on a business trip where you don't have to bring an annoying cpap machine on the plane.

Yeah, I'll be flying 14 hours this Friday and it could be helpful (I don't use a CPAP - yet).

 

[nothuman]

My AHI was 13 on my sleep study so this is something I’m interested in hearing more about if it can replace my CPAP

Glad you posted this!

 

[UnholyAlliance]

A bladder relaxant and a cognition drug for ADD and ADHD combined sounds like an interesting mix.

I think I personally would stick to my CPAP over mixing these meds. But I'm always fascinated to follow the research of items as they undergo testing.

Would you ever want to get into a trial of these meds?

 

[danieltx]

Good find, very interesting.

What I'm curious about is the index scores - are they based on a sleep study or CPAP use? I have to think sleep study as my index scores from my machine are always under 1 - if it's 0.5 that's high. I never did a sleep study before getting my CPAP so not sure if this would be effective for me.

 

[WeakFNG]

I have clients on atomoxetine (mental health, not a trainer. Hahaha) so when I saw this combo I was interested and kinda confused to be honest. Could be a nice option for some if it works. Though many people report good results, I haven't met many people who love having to wear a cpap.

 

[mafianick]

Where get these pills or need prescription?

 

[BIG1512]

Does it help keep you awake like say provigil?

 

[Dens228]

Where get these pills or need prescription?

It's not approved in the US yet.

 

[Dawgpound_Hank]

Good find, very interesting.

What I'm curious about is the index scores - are they based on a sleep study or CPAP use? I have to think sleep study as my index scores from my machine are always under 1 - if it's 0.5 that's high. I never did a sleep study before getting my CPAP so not sure if this would be effective for me.

From the study I would certainly think, as my study showed 71x (advanced stage) per hour stopping breathing, and when using the cpap, it usually reads around .3x to .5x per hour. DRAMATICALLY lowered mine.

 

[Earl]

Yeah, I'll be flying 14 hours this Friday and it could be helpful (I don't use a CPAP - yet).

They make little travel ones u can use

 

[Dens228]

They make little travel ones u can use

Yep, I recently bought and Airmax Mini. The hose takes up more room than the CPAP unit.

 

[Reno911]

I know CPAP's for some take an adjustment period BUT... if you are going to be north of say even 225 for most of your adult life there's no price you can put on the importance of wearing one nightly.

13 years ago I tested "severe" at 60+ episodes/hour and over a minute w/o breathing. I can't imagine the more damage I would have been causing these last 13 years without one.

 

[danieltx]

I know CPAP's for some take an adjustment period BUT... if you are going to be north of say even 225 for most of your adult life there's no price you can put on the importance of wearing one nightly.

13 years ago I tested "severe" at 60+ episodes/hour and over a minute w/o breathing. I can't imagine the more damage I would have been causing these last 13 years without one.

I'll bet money that Larry Allen's death over the weekend was related to sleep apnea.

 

[Reno911]

I'll bet money that Larry Allen's death over the weekend was related to sleep apnea.

I was thinking the same thing. Sleep apnea, severe LVH, Atherosclerosis, unchecked BP, etc.

All of the things that come along with being a large human and in his case an athletic freak.

 

[BIG1512]

I just started using mine nightly about 2.5 weeks ago. When did the daytime sleepiness subside for you all once you started on the cpap?

 

[Earl]

It takes a couples to really feel better . Let say it helps a lot but it's not a cure all brother
Plus you may have to go up on pressure also . Its just something you have to work just gear nobody is same