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PGE1 dosing

nothuman

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Picked some up "just in case."

I'm sure the "you're crazy, you shouldn't need to inject your dick" sexual superstars will be tempted to take up bandwidth with replies but I'd rather you didn't.

Now to the point...

Spent an annoyingly long amount of time trying to get info on proper dosing and have seen anywhere from 2.5-30mcg. I'd want to use the lowest effective dose if I ever end up taking it. The unconstituted vial contains 1000mcg (1mg), so it seems like it would be far too easy to overdose it given how little you'd want to use. Also, how many ml of bac water do people constitute it with?

Also, what type of slin pin is best? 31g with 5/16 inch? is 29g 1/2 inch too thick?
 
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Sides

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Spent an annoyingly long amount of time trying to get info on proper dosing and have seen anywhere from 2.5-30mcg. I'd want to use the lowest effective dose if I ever end up taking it. The unconstituted vial contains 1000mcg (1mg), so it seems like it would be far too easy to overdose it given how little you'd want to use. Also, how many ml of bac water do people constitute it with?

Also, what type of slin pin is best? 31g with 5/16 inch? is 29g 1/2 inch too thick?

To be honest, this will take trial and (probably some) error on your part, as the dose needed does vary so much from individual to individual. Start low with your dose, see if it works, then go up if you need to depending upon your response.

Also, the purity of research chemical PGE-1 is typically much less than real pharmaceutical PGE-1 (Caverject, TriMix, alprostadil, etc.) I have used both human grade pharma (I am now prescribed TriMix) and the research chem stuff, and while the human grade stuff is consistent, the research chem stuff can vary from one company to another, depending on where they are getting the raws.

For real pharma PGE-1 (Caverject or TriMix), I know that 10 mcg will give me a suitable erection for penetration, while 20mcg will give me a rock-hard porn star erection that lasts for hours. So an effective dose can be somewhere in the middle, depending on what I have planned for the night. ;-)

With the research chem PGE-1, it will be more difficult to pin down (quite literally.) One research chem company offers 2mg vials, but 1mg of their stuff is equivalent to 20mcg of the real pharma PGE-1. Another research company who used to be a sponsor here, offered 200mcg vials and now I believe they offer 1000mcg vials. But it took 50mcg of their PGE-1 to give me a good hard erection, so a 200mcg vial only had 4 doses in it.

So this will be something you have to experiment with to find the right dosage for you, which is why most patients usually are given their first injection in the doctor's office so they can try to find the right dose together. My urologist knew I was already used to using PGE-1 on my own, so he had no problem just writing me a script for TriMix because he knew I was already experienced in using it on my own.

As far as how much bac water to reconstitute with, you don't need much as you want to keep the injection volume low, but use enough to make it easy to measure on the slin pin. If I hypothetically had a 1000mcg vial of research chem PGE-1, and knew my dose was going to be 50mcg, then I might reconstitute with 2ml of bac water, so that I would know that 10 units on a slin pin would be a 50mcg dose. But adjust the math to what is most convenient for you, the amount of diluent won't have an effect on your results.

Regarding what kind of slin pins to use, I used to use 29 gauge 1/2" pins, but long ago I switched to the 31 gauge 5/16" pins, and they are much better. My urologist prescribes the 31 gauge pins along with my TriMix, and they work great. You don't need the needle to be long, it only has to be just long enough to go through the skin and tunica into the corpus cavernosum that runs along both sides of the penis. Inject at 10 o'clock or 2 o'clock along the sides, never into the top or bottom as shown at the following link:

https://www.mskcc.org/cancer-care/patient-education/penile-injection-therapy

Boards like www.franktalk.org are good for research and a lot of the inevitable questions that will arise (pun intended) as you experiment with PGE-1.

The first experience will be a little daunting to you, but after you get used to it, no problem at all and it becomes very easy. PGE-1 has allowed me to have a lot of great sexual experiences in life that I am glad that I have had. Let me know if I can help any further.
 

nothuman

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To be honest, this will take trial and (probably some) error on your part, as the dose needed does vary so much from individual to individual. Start low with your dose, see if it works, then go up if you need to depending upon your response.

Also, the purity of research chemical PGE-1 is typically much less than real pharmaceutical PGE-1 (Caverject, TriMix, alprostadil, etc.) I have used both human grade pharma (I am now prescribed TriMix) and the research chem stuff, and while the human grade stuff is consistent, the research chem stuff can vary from one company to another, depending on where they are getting the raws.

For real pharma PGE-1 (Caverject or TriMix), I know that 10 mcg will give me a suitable erection for penetration, while 20mcg will give me a rock-hard porn star erection that lasts for hours. So an effective dose can be somewhere in the middle, depending on what I have planned for the night. ;-)

With the research chem PGE-1, it will be more difficult to pin down (quite literally.) One research chem company offers 2mg vials, but 1mg of their stuff is equivalent to 20mcg of the real pharma PGE-1. Another research company who used to be a sponsor here, offered 200mcg vials and now I believe they offer 1000mcg vials. But it took 50mcg of their PGE-1 to give me a good hard erection, so a 200mcg vial only had 4 doses in it.

So this will be something you have to experiment with to find the right dosage for you, which is why most patients usually are given their first injection in the doctor's office so they can try to find the right dose together. My urologist knew I was already used to using PGE-1 on my own, so he had no problem just writing me a script for TriMix because he knew I was already experienced in using it on my own.

As far as how much bac water to reconstitute with, you don't need much as you want to keep the injection volume low, but use enough to make it easy to measure on the slin pin. If I hypothetically had a 1000mcg vial of research chem PGE-1, and knew my dose was going to be 50mcg, then I might reconstitute with 2ml of bac water, so that I would know that 10 units on a slin pin would be a 50mcg dose. But adjust the math to what is most convenient for you, the amount of diluent won't have an effect on your results.

Regarding what kind of slin pins to use, I used to use 29 gauge 1/2" pins, but long ago I switched to the 31 gauge 5/16" pins, and they are much better. My urologist prescribes the 31 gauge pins along with my TriMix, and they work great. You don't need the needle to be long, it only has to be just long enough to go through the skin and tunica into the corpus cavernosum that runs along both sides of the penis. Inject at 10 o'clock or 2 o'clock along the sides, never into the top or bottom as shown at the following link:

https://www.mskcc.org/cancer-care/patient-education/penile-injection-therapy

Boards like www.franktalk.org are good for research and a lot of the inevitable questions that will arise (pun intended) as you experiment with PGE-1.

The first experience will be a little daunting to you, but after you get used to it, no problem at all and it becomes very easy. PGE-1 has allowed me to have a lot of great sexual experiences in life that I am glad that I have had. Let me know if I can help any further.

Thank you, this is a great reply!
 

69cyclerider

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I've used Qudmix before and the dosage for me was as follows :
10mcg = 1 hour erection
15mcg = 2 hour erection
20mcg = 3+ hour porn star erection

I have a applicator for the needle and when I get back home I'll upload a picture. You place the needle in the device, cock it ( spring loaded ) and place it where you want it and press the button and it will insert at the proper depth. Then you just push the plunger in and you're done.

Good luck
 

mike036

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I've used Qudmix before and the dosage for me was as follows :
10mcg = 1 hour erection
15mcg = 2 hour erection
20mcg = 3+ hour porn star erection

I have a applicator for the needle and when I get back home I'll upload a picture. You place the needle in the device, cock it ( spring loaded ) and place it where you want it and press the button and it will insert at the proper depth. Then you just push the plunger in and you're done.

Good luck
Years ago there was good research pge-1 that a 15mcg dose would give me a 2-3 hour erection. Those days are long gone.With the more recent research pge-1 I need anywhere from 24-44 just to achieve a 1-2 hour erection
 

69cyclerider

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I've never used PGE-1 ,but I've been researching it and probably will buy some and try it on my rat. Another one that is promising is PT-141, the active ingredient in Melanotan II that gives erections. Youtube videos out on the net also for that compound. PT-141 is also FDA approved.
 

Sides

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PT-141 and Melanotan-II both work well in helping make it easier to get a more natural erection, and with those you only need a subcutaneous injection in the abdomen, not an intercavernosal injection. So I would stay with MT-II or PT-141 as long as possible, depending on your goals. However, use it too often and the effect lessens and wears off. If someone takes PT-141 or MT-II regularly, it won't have the same effect any more.

If you look at the adult film industry, almost all the male stars use Caverject or some kind of PGE-1 (although few of them will admit to it, it is common knowledge in the industry). When making a living depends on having a rock-hard erection that won't go away for a least a couple hours, you have to go with the option that works best...or else you might be out of work.

For most people, they should always stay with the least amount of the least invasive option for as long as they can. Start out with Viagra or Cialis, then use PT-141 or MT-II if necessary, then if you have to go with the intercavernosal injections like PGE-1.
 

j2048b

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Talking about this ive always wondered how some get pins also in their nodules or some area to ward off pre mature ejac, now wouldnt that be a safer place to address and start? Or is it people just wanting porn star erections?

Sent from my SM-G935V using Tapatalk
 

nothuman

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I've never used PGE-1 ,but I've been researching it and probably will buy some and try it on my rat. Another one that is promising is PT-141, the active ingredient in Melanotan II that gives erections. Youtube videos out on the net also for that compound. PT-141 is also FDA approved.

I have some PT141 that I haven't used. I can't say MT2 gave me any dramatic erections though. Maybe it was a dosing thing. Honestly, not jerking off and taking Cialis gives me the best erections but I think I'll try the PGE1 I have. Already put 3ml in there.
 

Sides

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Talking about this ive always wondered how some get pins also in their nodules or some area to ward off pre mature ejac, now wouldnt that be a safer place to address and start? Or is it people just wanting porn star erections?

Sent from my SM-G935V using Tapatalk

It's all about guys wanting porn star erections. ;-)

PGE-1 has nothing to do with warding off premature ejaculation, although as a nice side effect it does make premature ejaculation irrelevant. When you use PGE-1, your cock stays hard for 1-2 hours no matter what you do, and whether you cum or not. So you will stay hard even if you have already cum inside your girl. Just keep on thrusting away until she has also cum (or at least until she is satisfied or until she gets tired of you.)

Many times I have cum inside women, then they are amazed that I can keep on fucking them for an hour or more. Or I will fuck her, then we will take a break and cuddle for a while, then since I am still hard I will fuck her again, and again...

PGE-1 erections won't go away no matter what you do for 1-2 hours. You could be just sitting there reading the paper or paying bills and your cock will still be hard the whole time. Just make sure you don't have visitors stopping by without calling first, or they might be a bit surprised when you come open the door with a raging hard-on. ;-)
 

maldorf

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It's all about guys wanting porn star erections. ;-)

PGE-1 has nothing to do with warding off premature ejaculation, although as a nice side effect it does make premature ejaculation irrelevant. When you use PGE-1, your cock stays hard for 1-2 hours no matter what you do, and whether you cum or not. So you will stay hard even if you have already cum inside your girl. Just keep on thrusting away until she has also cum (or at least until she is satisfied or until she gets tired of you.)

Many times I have cum inside women, then they are amazed that I can keep on fucking them for an hour or more. Or I will fuck her, then we will take a break and cuddle for a while, then since I am still hard I will fuck her again, and again...

PGE-1 erections won't go away no matter what you do for 1-2 hours. You could be just sitting there reading the paper or paying bills and your cock will still be hard the whole time. Just make sure you don't have visitors stopping by without calling first, or they might be a bit surprised when you come open the door with a raging hard-on. ;-)

Isnt there some danger in doing this though? I think literature says and erection lasting longer than 4 hours can cause permanent damage. From what you are saying though, this only lasts 1 to 2 hours. Could it last longer if you take too much, or would that just make the erection more intense but last the same length of time?
 

mike036

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Isnt there some danger in doing this though? I think literature says and erection lasting longer than 4 hours can cause permanent damage. From what you are saying though, this only lasts 1 to 2 hours. Could it last longer if you take too much, or would that just make the erection more intense but last the same length of time?

The more you take the longer the erection will last
 

maldorf

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The more you take the longer the erection will last

Yikes. Ive read online about guys having to go to the er and have blood drained out of their peter once it becomes painful. I don't think those cases were caused by using this though, rather some kind of medical condition.
 

jeroendebleser

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Yikes. Ive read online about guys having to go to the er and have blood drained out of their peter once it becomes painful. I don't think those cases were caused by using this though, rather some kind of medical condition.

Priapism is what it's called. It's a possible side effect of an old antidepressant called Trazodone that is used for sleeping issues nowadays. I've had it many times (went to sleep rock hard, woke up still rock hard) but to me, it isn't painful so I sure as hell never thought of getting my penis drained :eek:
 

Sides

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Isnt there some danger in doing this though? I think literature says and erection lasting longer than 4 hours can cause permanent damage. From what you are saying though, this only lasts 1 to 2 hours. Could it last longer if you take too much, or would that just make the erection more intense but last the same length of time?

As with any drug, the dose makes all the difference, or the dose makes the poison if you take too much. I've certainly had erections that lasted 4-6 hours or more, although I don't recommend it as there is definitely a risk of doing lasting damage to the penis. So guys should always start out very low and conservative with their dosages and go up only when necessary.

Most guys won't have a true priapism with PGE-1, the erection will eventually go away after 1-2 hours if you use a reasonable dose. Just have more sex or jerk off, and eventually it will go down on it's own when the PGE-1 wears off.

Some men's clinics do stock and offer injectable phenylephrine to make your cock go down if you do develop priapism, but most men won't have a need for that. You can also take ephedrine or pseudoephedrine or benadryl to help make it go down if necessary, but I have never had to use any of those things.

I have been using PGE-1 off and on for 13 years now, and I have never had any serious problem with it. I have hit veins by mistake and developed a hematoma under the skin, a purple bruise that eventually goes away on it's own. And you can develop fibrosis and scar tissue if you keep injecting into the same sites over and over, so it's important to switch up your injection sites.

Most serious problem I ever had was when I hit a vein, and the PGE-1 went through the blood back into systemic circulation, instead of staying in the corpus cavernosum where it is supposed to be. I suddenly burst into a cold sweat and got very dizzy and had to sit down, and didn't get an erection. But again, that feeling went away on it's own and an hour later I was feeling alright again.

Like many other things, if you use reasonable dosages and pay attention to what you are doing, you won't have a problem with it.
 

maldorf

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[ame="https://www.youtube.com/watch?v=yodPCrBVy9M"]MM - Priapism (painful prolonged erection) - YouTube[/ame]
 

69cyclerider

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I've used Sudafed to bring an erection down of bed be. Has always worked without failure.
 

nothuman

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I've never used PGE-1 ,but I've been researching it and probably will buy some and try it on my rat. Another one that is promising is PT-141, the active ingredient in Melanotan II that gives erections. Youtube videos out on the net also for that compound. PT-141 is also FDA approved.

I know people say the research stuff is usually underdosed, but honestly I'd rather that than it being overdosed. I'd rather fail to get a boner than end up in the hospital
 

Sides

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I know people say the research stuff is usually underdosed, but honestly I'd rather that than it being overdosed. I'd rather fail to get a boner than end up in the hospital

As long as the product is consistent and you know what to expect from the dose you are taking, then the research chem stuff can be just as good as the pharm stuff.

I have a prescription for TriMix now, which I like just because it is cheap and consistent...I can trust that the compounding pharmacy will always make it to the correct dosage and I don't have to worry about an underdosed or overdosed product. And I get it FedExed to me by the pharmacy in a cold pack, right to the house, so it's very convenient. So it's nice to have a prescription if you can get one.

But the downside of the prescription TriMix is that it comes already reconstituted by the pharmacy, in a 5ml vial, so it has to be kept refrigerated so the product doesn't degrade (although alprostadil degrades very slowly.)

I still use the research chem PGE-1 from time to time just because I can reconstitute it using very little bac water, so the injection volume is smaller. I just draw it up into a 31g 5/16" .3ml insulin pin, which fits very comfortably in an eyeglasses case in my pocket, then I can take it with me if I am going out to eat at a restaurant with a girl or if I am meeting her at a hotel to have some fun. Then when it's time to have fun, I can just go to the bathroom, inject quickly, then come back out and have fun with her, with her not even knowing that I am using the PGE-1.

So both the pharm and the research chem PGE-1 can be useful, depending on how you plan on using it.
 

nothuman

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As long as the product is consistent and you know what to expect from the dose you are taking, then the research chem stuff can be just as good as the pharm stuff.

I have a prescription for TriMix now, which I like just because it is cheap and consistent...I can trust that the compounding pharmacy will always make it to the correct dosage and I don't have to worry about an underdosed or overdosed product. And I get it FedExed to me by the pharmacy in a cold pack, right to the house, so it's very convenient. So it's nice to have a prescription if you can get one.

But the downside of the prescription TriMix is that it comes already reconstituted by the pharmacy, in a 5ml vial, so it has to be kept refrigerated so the product doesn't degrade (although alprostadil degrades very slowly.)

I still use the research chem PGE-1 from time to time just because I can reconstitute it using very little bac water, so the injection volume is smaller. I just draw it up into a 31g 5/16" .3ml insulin pin, which fits very comfortably in an eyeglasses case in my pocket, then I can take it with me if I am going out to eat at a restaurant with a girl or if I am meeting her at a hotel to have some fun. Then when it's time to have fun, I can just go to the bathroom, inject quickly, then come back out and have fun with her, with her not even knowing that I am using the PGE-1.

So both the pharm and the research chem PGE-1 can be useful, depending on how you plan on using it.

How long does it take for it to work? Is it totally immediate since all you're doing is going to the bathroom before to do it?

Also, how much less painful is using a 31g as opposed to a 29g? I only have 29g and a little worried it could hurt a bit. I could order 31g but only if it really makes a difference
 

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