Proof that Cabergoline does NOT lower IGF levels.

[Thebigone]

I have been on cabergoline(.5mg 2x per week) for like 7years or so while on gh/peps,etc.... Recently it concerned me when I read a few things about how it can lower IGF levels so I decided to get some lab work done. A few months ago I stayed on serostim's at 3iu per day for a while and then did the 10iu test for GH serum and also tested IGF levels. My IGF was 327. During this time I was also on ghrp2/cjc no dac and 10mg Mk677. So I decided to stop the cabergoline and get bloods drawn 2 weeks later to see if there was any change.I still stayed on all the same peps/compounds as well but even added 3500mg cjc with dac(im pretty sure its bunk) IGF was 293 and prolactin was still less than .01 Maybe I needed to wait longer but even 2weeks there should have been some change to IGF increasing if caber really lowers it. If anything my results are now lower but that could be due to not doing the 10iu shot 3hrs before and just staying on the 3iu daily. But regardless it did not effect my IGF levels at all.

 

[raw33man]

For 7 years??? You know Caber is dopamine agonist... I'm afraid you can never come off or you'll go nutz

 

[Stewie]

Not sure the reasoning for being on a D2 agonist for an extended period of time. That's your call, not mine.

Keep in mind tho, low prolactin levels can induce a few dysfunctional sexual side effects. And possibly set the stage for metabolic syndrome. The latter, very unlikely. The former, um, very possible.

 

[criticalben1]

I'm glad to see some one running caber and gh and peps post an igf test. I'd be interested to see your results a couple more weeks from now. Thanks for posting. I like caber better than prami due to insomnia on prami. I've put off trying gh because of the possibility of caber blocking igf. I live in a state where you can't do blood work without a doctors order or I would test this my self. Thanks again.

 

[RamboStallone]

I never saw that study that claimed that but just in general you shouldn't take all these studies as gospel. There is a lot of things we see in real life applications that don't agree with studies.

Thanks for sharing.

 

[criticalben1]

Cabergoline is used to treat acromegaly. It does so by lowering igf. It may also lower gh I don't remember. There are a lot of studies if you look it up with acromegaly. I guess the peptides still force the gh release even with caber. Or maybe it only works on people with acromegaly, idk. I think I saw a post about a guy taking a bunch of gh and still having low igf levels though. So I still wonder if maybe it stops the liver from making igf from the gh or slows that process?

 

[kinglewy]

Not sure the reasoning for being on a D2 agonist for an extended period of time. That's your call, not mine.

Keep in mind tho, low prolactin levels can induce a few dysfunctional sexual side effects. And possibly set the stage for metabolic syndrome. The latter, very unlikely. The former, um, very possible.

I've always had crazy sexual experiences on caber and loved it; able to go over and over/multiple orgasms/awesome erections etc....

Do these things stop with prolonged use? I've never taken it for too long, just short runs, its a bit pricey to run all the time.

 

[Jizzmo]

nice proof there.

i especially liked the reliability and design of your one person study and the way you excluded any possible influencing factors, the huge control group and assured consistency of all your gear.

 

[Stewie]

I've always had crazy sexual experiences on caber and loved it; able to go over and over/multiple orgasms/awesome erections etc....

Do these things stop with prolonged use? I've never taken it for too long, just short runs, its a bit pricey to run all the time.

We have neurons that receive information from sensory organs say such as that of the glans, weird as it sounds, the head of your penis, that communicate with other neurons for an action potential. This is termed synaptic transmission. We have sensory terminals that communicate with dopamine in our glans.

We'll piece this together.

When we change the natural rhythm of a physiological or biological reaction, such as that of neurotransmission, these action potentials communicate with threshold potentials. Threshold potentials can be over-stimulated (hyperpolarization) for only so long leading to tachyphylaxis of a drug. This is more common with drugs that act on our nervous system. To put it in more simple terms, this is seen with those who use meth, crack or cocaine that create an over-stimulus of dopamine. Dopamine is dopamine, regardless of how the stimulus of an action potential was created.

As for yourself, the short term use of caber more than likely won't cause a dysfunctional synaptic transmission response. I would suspect that once you stop the caber you experienced short term sexual dysfunction, such as premature ejaculation or delayed ejaculation? Maybe not?

It's just not a good idea to overstimulate our nerotransmitters for extended periods of time. Something negative does bound to happen.

 

[RamboStallone]

We have neurons that receive information from sensory organs say such as that of the glans, weird as it sounds, the head of your penis, that communicate with other neurons for an action potential. This is termed synaptic transmission. We have sensory terminals that communicate with dopamine in our glans.

We'll piece this together.

When we change the natural rhythm of a physiological or biological reaction, such as that of neurotransmission, these action potentials communicate with threshold potentials. Threshold potentials can be over-stimulated (hyperpolarization) for only so long leading to tachyphylaxis of a drug. This is more common with drugs that act on our nervous system. To put it in more simple terms, this is seen with those who use meth, crack or cocaine that create an over-stimulus of dopamine. Dopamine is dopamine, regardless of how the stimulus of an action potential was created.

As for yourself, the short term use of caber more than likely won't cause a dysfunctional synaptic transmission response. I would suspect that once you stop the caber you experienced short term sexual dysfunction, such as premature ejaculation or delayed ejaculation? Maybe not?

It's just not a good idea to overstimulate our nerotransmitters for extended periods of time. Something negative does bound to happen.

I'm assuming prami would fall under this as well correct brother? I've heard of a couple guys saying they were addicted to prami use and using it years on end.

 

[Thebigone]

nice proof there.

i especially liked the reliability and design of your one person study and the way you excluded any possible influencing factors, the huge control group and assured consistency of all your gear.

I took Caber for seven years and had IGF levels tested. Then I stopped the drug and had igf retested. What more proof do you need? Sure it was not a controlled study in a lab by a doctor with a team, etc. but it's pretty cut and clear.

Anyway my prolactin was still less than zero after being off for two weeks so I think I will stay off another month or six weeks and get retested again just to see if there are any changes.

 

[Stewie]

I'm assuming prami would fall under this as well correct brother? I've heard of a couple guys saying they were addicted to prami use and using it years on end.

Yes it very well could. It goes without saying, pleasure can bring pain.

 

[RamboStallone]

I don't think studies on people with acromelagy should be applied to people without. They have a pituitary problem. I think it's apples to oranges.

 

[criticalben1]

I took Caber for seven years and had IGF levels tested. Then I stopped the drug and had igf retested. What more proof do you need? Sure it was not a controlled study in a lab by a doctor with a team, etc. but it's pretty cut and clear.

Anyway my prolactin was still less than zero after being off for two weeks so I think I will stay off another month or six weeks and get retested again just to see if there are any changes.

OP I'm ot trying to be an ass but I think I read somewhere that it takes several weeks for the gh and igf to return to normal after stopping caber.

 

[criticalben1]

I don't think studies on people with acromelagy should be applied to people without. They have a pituitary problem. I think it's apples to oranges.

I agree completely. I have not found any studies or even much blood work by bodybuilders on caber and gh or peps, that's why I was glad to see someone testing on here.

 

[kinglewy]

I took Caber for seven years and had IGF levels tested. Then I stopped the drug and had igf retested. What more proof do you need? Sure it was not a controlled study in a lab by a doctor with a team, etc. but it's pretty cut and clear.

Anyway my prolactin was still less than zero after being off for two weeks so I think I will stay off another month or six weeks and get retested again just to see if there are any changes.

Is it ok to have zero prolactin? Does it play any other role in a male body other than a negative one?

Like estro...you dont want high estrogen but you dont want to crush it either.

 

[Ashop]

I've always had crazy sexual experiences on caber and loved it; able to go over and over/multiple orgasms/awesome erections etc....

Do these things stop with prolonged use? I've never taken it for too long, just short runs, its a bit pricey to run all the time.

What type of dosages/regimen do you use?

 

[kinglewy]

What type of dosages/regimen do you use?

.5 every third day...honestly there were times I didn't need it even while running tren and would take it before going out with a chick along with cialis for a good time afterwards. The only time I really really need it is with npp or deca which is why I dont run those, although this time with tren I have gyno which has never happened before ever....but I got some caber today thanks to a PM member who lives nearby, gonna do .5 mg every3days and see how it goes...hoping it works because my sex drive is shot and the lumps under my nipples are getting bad.

 

[Stewie]

Is it ok to have zero prolactin? Does it play any other role in a male body other than a negative one?

Like estro...you dont want high estrogen but you dont want to crush it either.

Low prolactin is associated with sexual dysfunction and psychological or metabolic disturbances in middle-aged and elderly men: the European Male A... - PubMed - NCBI

Men's Sexual Problems Linked To Breast Milk Hormone: Low Prolactin Levels Could Inhibit Sexual Function, Psychological Health

Prolactin is involved with many physiological and biological actions such as immunological and dermatological.

**broken link removed**

Prolactin in the Immune System | InTechOpen




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10-03-2014, 04:52 PM



Stewie

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Join Date: Feb 2011

Posts: 3,253

Short-term hypoprolactinemia, generally has no health effects. Other than loss of libido.

Long-term hypoprolactinemia on the other hand can cause infertility, which has a direct effect on spermatogenesis. Being on a cycle, your fertility is probably zilch anyway. The aforementioned is an FYI on spermatogenesis.

Our immune system is dependent on physiological levels of prolactin, like with many other hormones, prolactin is a immunoregulating hormone. We have prolactin receptors in our T lymphocytes and B lymphocytes, this also could disrupt macrophage activation. Not a good thing. Both, T and B lymphocytes produce antibodies against foreign antigens, such as bacterial infections. So I'd be a little cautious on long-term hypoprolactinemia. I would concentrate on keeping your estradiol levels in a healthy physiological range, this will help control your prolactin levels. An occasional D2 agonist, isn't a big deal. Long-term, I personally wouldn't use.

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[Thebigone]

Well shoot maybe this is why I get sick a lot. I'm going to stay off of it for a while and get retested to see if my prolactin levels come back .as far as libido I have not noticed any changes whatsoever everything is fine thank God.