- Joined
- Sep 22, 2011
- Messages
- 537
“E2 can protect both isolated cardiac myocytes and the intact heart from ischemia-related injury. In isolated aged cardiac myocytes, estrogen loss is associated with increased expression of inflammatory cytokines and increased susceptibility to ROS. After injury, such as myocardial infarction or hypertension, the heart undergoes pathologic remodeling, which leads to deleterious effects on cardiac function. E2 has an inhibitory effect on this adverse remodeling and the salutary effects of E2 appear to be mediated primarily through ERβ. Estrogen has numerous beneficial effects on the mitochondria including increased mitochondrial gene transcription and increased activation of proteins involved in ROS removal”There seems to be a steady but growing axiom that even slightly elevated estrogen is bad for your health, a push for aromatase inhibitor use, at least on the internet.
We just dont know and are going by theory a lot of the time, as opposed to practical human studies.
The only thing the silver age guys had available was Testosterone beginning 1940,Dbol beginning 1958 and Deca beginning in 1960. Correct me if Im wrong, but I dont think Aromatase inhibitors were a thing until about 1980. Many of those Silver age guys lived to at least the average male life expectancy in the US of age 76, many lived past that and some of them even made it to their 90s, all while having elevated estrogen. It appears they certainly lived longer than even their Golden age counterparts.

Estrogen and the Cardiovascular System
Estrogen is a potent steroid with pleiotropic effects, which have yet to be fully elucidated. Estrogen has both nuclear and non-nuclear effects. The rapid response to estrogen, which involves a membrane associated estrogen receptor(ER) and is protective, ...
