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Norditropin contains Mannitol and was used in the study where HR barely fluctuated;
In this study alone it’s contributed to cardiac remodeling and a 10% increase in the left ventricular wall thickness.I’ve been searching for days as to why some Gh increases RHR. My findings are inconclusive, however, I found this study showing that pharma Gh does not increase RHR. 9iu/day increases RHR by 1 bpm. 18iu/day increased RHR by 5 bpm.
Supraphysiological Doses of GH Induce Rapid Changes in Cardiac Morphology and Function
Abstract. GH is an agent widely used in sport to improve physical performance and has been proposed as adjunctive therapy in several clinical conditions. Hacademic.oup.com
1.5 weeks ago I started some GH from a well known supplier who I love. At 3.33 iu/day, my RHR increased from 55-60 bpm to 88 beats per minute. On one hand, normal heart rate is 60-100 bpm, so I’m within range. On the other hand, a 50% increase in Resting Heart Rate overnight can’t be healthy. Needless to say, I’m stopping the Gh. It’s unfortunate because my muscles were already fuller, skin was tightening, sleep was increased by roughly 20%.
As mentioned, I’ve been searching for days but can’t find any conclusive evidence as to why some gh does this. Does anyone have any idea why?
Rookie mistake.
It is true that the main basis evaluated the cardiac remodeling, however, they measured heart rate.In this study alone it’s contributed to cardiac remodeling and a 10% increase in the left ventricular wall thickness.
While that may not seem like much, a 10% change in the heart is one the body will absolutely have to adjust to.
One could argue that ARB’s and Nebilivol could be used to combat this change, but none the less will be a physiological change that will be felt by most.
Apologies as I responded earlier before reading the actual study.
| Placebo n = 25 | Low GH n = 17 | High GH n = 18 | |
|---|---|---|---|
| Age (yr) | 23 ± 0.5 | 24 ± 0.7 | 24 ± 0.4 |
| Body mass indexBaseline | 22 ± 1 | 23 ± 1 | 23 ± 1 |
| Body mass index4 wk | 22 ± 1 | 23 ± 1 | 23 ± 1 |
| Heart rateBaseline (bpm) | 67 ± 2 | 63 ± 2 | 67 ± 2 |
| Heart rate4 wk (bpm) | 68 ± 1 | 64 ± 2 | 72 ± 2 |
| IGF-IBaseline (μg/liter) | 301 ± 17 | 363 ± 40 | 325 ± 22 |
| IGF-I4 wk (μg/liter) | 312 ± 16 | 608 ± 71a,b | 768 ± |
Interesting. Keep in mind as well that this was only a 4 week study if recall correctly. I don’t know anyone who has much benefit or who only does 4 week cycles of HGH.
I’d like to see it after 3-6 years…. Let’s not fool ourselves, anybody who’s honest with themselves knows that super physiological doses GH, AAS, etc isn’t healthy. I’ve made my peace with it.Interesting. Keep in mind as well that this was only a 4 week study if recall correctly. I don’t know anyone who has much benefit or who only does 4 week cycles of HGH.
Show me someone’s vitals after 3-6 months of usage with cardiac remodeling. That would be of more interest to me.
Agreed. And as much as everyone likes to think an ARB and some Nebilivol is going to erase any of those outcomes is honestly kidding themselves.
My instinct is to agree. I think we are going down the wrong path with this one.
Interesting. How is your cardio and by any chance did you add any supplements at the same time?
pretty good cardio, saw here on this message board that adding two or 3 g of vitamin C can help with the water retention but not sure that helped… started 2.5 of neb later on but fatigue was pretty bad and heart rate dropped may be a little too much… if you have any other ideas for supplements please let me know… I had added a bit of amlodipine for blood pressure and that helped a bit
So glad you shared this. I was considering Jintropin as a replacement for the generics spiking my heart but not now. I will be sticking with Norditropin, Genotropin, Omnitrope moving forward, all of which do not give me this scary side effect.
Do share....where ya getting pharma?
Even more than generic?Interestingly, Seros cause me to hold more water than any of them, but one could argue that’s due to the potency.
You want me to share my sources for these? Is this allowed on here?
I’ve used a few kits of Serostim and a few kits of Humatrope. Both Serostim and Humatrope are wet Gh and cause me to hold as much if not more water than generics. 5-7 lbs.
No it’s not. That’s actually rule number one.
