Telmisartan without high BP.

[beast405]

I’ve felt like my blood pressure has always ran a little bit high. My new doctor has this nurse that takes my blood pressure and I swear he doesn’t do it right or something. He always says 120/80 you’re doing good bud! Im going to have to just start complaining of BP symptoms I guess! Right now, I can just feel my blood pressure is elevated. Did you have to steer your doctor in the direction of those two meds? (telmisartan and empagliflozin). It seems like there are so many to choose from.

You could always tell him it runs a tad bit high normally. Tell a buddy of yours had good results from telmisartan and go from there. It shouldn’t be hard for him to prescribe it since it’s not a narcotic. And I can say that telmisartan is the shit !!! It keeps my blood pressure within range with basically no sides

 

[Keefs]

You could always tell him it runs a tad bit high normally. Tell a buddy of yours had good results from telmisartan and go from there. It shouldn’t be hard for him to prescribe it since it’s not a narcotic. And I can say that telmisartan is the shit !!! It keeps my blood pressure within range with basically no sides

Thanks! I’ll probably go with something like that lol

 

[Keefs]

I don’t have a BP issue and never taken telmisartan before. I’ve been thinking about taking it for prevention for a Test Deca cycle. Last time I ran it those compounds BP was elevated. You think 20mg is a good place to start?

That’s what I’m running right now. First blast in a while and my BP is definitely up a little bit right now.

 

[whoremoan]

A little known side benefit to the class of antihypertensive drugs known as angiotensin II receptor blockers is that they enhance insulin sensitivity, increase utilization of fat as energy, and improve mitochondrial function.5,7,13,38,39,100 Of all the drugs in this class, telmisartan stands out as superior for potential longevity enhancement.101-103

As humans age, mitochondrial dysfunction becomes a deadly factor in the development of obesity, insulin resistance, endothelial breakdown, and type II diabetes.104-109 Telmisartan helps correct these underlying mechanisms of aging and death (as do many of the nutrients Life Extension® members already take).

Telmisartan activates a regulator of cellular energy called PPAR-gamma coactivator 1 alpha (PGC-1a), which stimulates the burning of excess calories.110,111 This can be a crucial factor in weight management.

Studies indicate that telmisartan directly stimulates PPAR-gamma (peroxisome proliferator-activated receptor gamma), a key inducer of beneficial metabolic effects.112-114 PPAR-gamma activating properties have also been reported for other angiotensin II receptor blocker drugs, but telmisartan is at least 10 times more powerful.112

Telmisartan has been shown in preclinical models to reduce weight gain, increase total energy expenditure, and increase expression of key mitochondrial enzymes in skeletal muscle better than a more popular drug in this class (Diovan®).7,13,39,115-117

Atherosclerosis remains a leading killer of Americans.118 Telmisartan functions by multiple mechanisms to protect against arterial occlusion,119-121 including increasing beneficial endothelial nitric oxide.39,122,123

Lastly, telmisartan appears to promote biochemical, biological, and metabolic effects that some researchers have suggested could boost athletic performance.112

Why Telmisartan Is Best For Blood Pressure - Life Extension

Generic telmisartan offers blood pressure control, improves insulin sensitivity, boosts mitochondrial activity, and enhances endothelial function.

www.lifeextension.com

in my experience , telmisartan does none of that
it lowers my bp yep sure
but doesnt do a single fucking thing for rbcs, cholesterol, or insulin sensitivity

it may for others but not me at all and ive been watching my bloods closely on it

also, i swear it keeps a layer of water or fat when dieting

i used for my 2nd last show and had a film of water or lower abs fat, i removed the telmi and did another comp a month later and was fine
i will prob only use offseason if needed

but im starting to turn against telmisartan

 

[Zamun]

in my experience , telmisartan does none of that
it lowers my bp yep sure
but doesnt do a single fucking thing for rbcs, cholesterol, or insulin sensitivity

it may for others but not me at all and ive been watching my bloods closely on it

also, i swear it keeps a layer of water or fat when dieting

i used for my 2nd last show and had a film of water or lower abs fat, i removed the telmi and did another comp a month later and was fine
i will prob only use offseason if needed

but im starting to turn against telmisartan

Have you noticed those benefits with other ARBs?

 

[whoremoan]

Have you noticed those benefits with other ARBs?

havent tried any other arbs tbh
but i have just started enalapril , and so far feel great, will get bloods in a month or so and update

 

[nothuman]

I don’t have a BP issue and never taken telmisartan before. I’ve been thinking about taking it for prevention for a Test Deca cycle. Last time I ran it those compounds BP was elevated. You think 20mg is a good place to start?

I’d go with 40mg

 

[nothuman]

in my experience , telmisartan does none of that
it lowers my bp yep sure
but doesnt do a single fucking thing for rbcs, cholesterol, or insulin sensitivity

it may for others but not me at all and ive been watching my bloods closely on it

also, i swear it keeps a layer of water or fat when dieting

i used for my 2nd last show and had a film of water or lower abs fat, i removed the telmi and did another comp a month later and was fine
i will prob only use offseason if needed

but im starting to turn against telmisartan

Same here. When people tell me take Telmisartan to lower HCT, little do they know I have been taking it for almost a decade and it has zero impact on that. And I was one of the first people here to preach the benefits of Telmisartan.

 

[whoremoan]

Same here. When people tell me take Telmisartan to lower HCT, little do they know I have been taking it for almost a decade and it has zero impact on that. And I was one of the first people here to preach the benefits of Telmisartan.

what does your hct and hemo sit at normally?
did you say you dont donate also ?

 

[bigzzz]

Same here. When people tell me take Telmisartan to lower HCT, little do they know I have been taking it for almost a decade and it has zero impact on that. And I was one of the first people here to preach the benefits of Telmisartan.

what does your hct and hemo sit at normally?
did you say you dont donate also ?

So in your guys opinion it is not worth taking for other benefits when you don't have BP issues?

 

[whoremoan]

So in your guys opinion it is not worth taking for other benefits when you don't have BP issues?

if i didnt have BP issues i wouldnt take it

 

[nothuman]

So in your guys opinion it is not worth taking for other benefits when you don't have BP issues?

That is definitely not my opinion.

I think it should be mandatory for any steroid user to take it in order to block the angiotensin receptor effects of AAS

 

[stevecleves]

Also, Dave Palumbo recently stated that Telmisartan is linked to “kidney cancer.” I don’t know which studies he was referring to but I have the video if you want to listen to it. I’m not saying it causes kidney cancer, but I can’t prove it doesn’t.

Theres this:

Risk of cancer with angiotensin-receptor blockers increases with increasing cumulative exposure: Meta-regression analysis of randomized trials

Angiotensin-receptor blockers (ARBs) are a class of drugs approved for the treatment of several common conditions, such as hypertension and heart failure. Recently, regulatory agencies have started to identify possibly carcinogenic nitrosamines and azido ...

www.ncbi.nlm.nih.gov

There was a highly significant correlation between the degree of cumulative exposure to ARBs and risk of all cancers combined (slope = 0.07 [95% CI 0.03 to 0.11], p<0.001), and also lung cancer (slope = 0.16 [95% CI 0.05 to 0.27], p = 0.003). Accordingly, in trials where the cumulative exposure was greater than 3 years of exposure to daily high dose, there was a statistically significant increase in risk of all cancers combined (I2 = 31.4%, RR 1.11 [95% CI 1.03 to 1.19], p = 0.006). There was a statistically significant increase in risk of lung cancers in trials where the cumulative exposure was greater than 2.5 years (I2 = 0%, RR 1.21 [95% CI 1.02 to 1.44], p = 0.03). In trials with lower cumulative exposure to ARBs, there was no increased risk of all cancers combined or lung cancer. Cumulative exposure-risk relationship with ARBs was independent of background angiotensin-converting enzyme inhibitor treatment or the type of control (i.e. placebo or non-placebo control). Since this is a trial-level analysis. the effects of patient characteristics such as age and smoking status could not be examined due to lack of patient-level data. In conclusion, this analysis, for the first time, reveals that risk of cancer with ARBs (and specifically lung cancer) increases with increasing cumulative exposure to these drugs. The excess risk of cancer with long-term ARB use has public health implications.

This analysis shows that risk of cancer and specifically lung cancer increase with increasing cumulative exposure to ARBs. The relationship between cumulative exposure to ARBs and cancer risk explains the heterogeneity in the results of randomized trials, since trials were highly heterogeneous in terms of cumulative exposure. Detailed and impartial analysis of the vast amount of patient-level data of randomized trials that the regulatory agencies already have, including examination of cumulative exposure—risk relationship, can confirm the current findings. Because of the ongoing widespread use of ARBs globally, their potential of excess cancer risk with long-term use has profound implications for patients and prescribing clinicians.

The three Telmisartan specific studies that were part of the meta analysis were 80mg a day.

Study Name​	Total n​	Condition Studied​	ARB used (dose received a)​	Recommended daily high dose of the ARB studied b​	Control Drug (dose received a)​	Duration of follow-up (months)​	Adherence to Study Drugs (%)​	Average Cumulative Exposure to ARB (years of daily high dose)​
ONTARGET​	25,620​	Cardiovascular disease or diabetes with end-organ damage​	Telmisartan (80 mg) or Telmisartan (80 mg) + Ramipril (10 mg)​	80 mg​	Ramipril (10 mg)​	56​	80​	3.73​
TRANSCEND​	5,926​	Angiotensin- converting enzyme intolerant patients with cardiovascular disease or diabetes with end-organ damage​	Telmisartan (80 mg)​	80 mg​	Placebo​	56​	80​	3.73​
PROFESS​	20,332​	Recent (<90 days) ischemic stroke​	Telmisartan (80 mg)​	80 mg​	Placebo​	30​	70​	1.75​

 

[Keefs]

Theres this:

Risk of cancer with angiotensin-receptor blockers increases with increasing cumulative exposure: Meta-regression analysis of randomized trials

Angiotensin-receptor blockers (ARBs) are a class of drugs approved for the treatment of several common conditions, such as hypertension and heart failure. Recently, regulatory agencies have started to identify possibly carcinogenic nitrosamines and azido ...

www.ncbi.nlm.nih.gov

The three Telmisartan specific studies that were part of the meta analysis were 80mg a day.

Study Name​	Total n​	Condition Studied​	ARB used (dose received a)​	Recommended daily high dose of the ARB studied b​	Control Drug (dose received a)​	Duration of follow-up (months)​	Adherence to Study Drugs (%)​	Average Cumulative Exposure to ARB (years of daily high dose)​
ONTARGET​	25,620​	Cardiovascular disease or diabetes with end-organ damage​	Telmisartan (80 mg) or Telmisartan (80 mg) + Ramipril (10 mg)​	80 mg​	Ramipril (10 mg)​	56​	80​	3.73​
TRANSCEND​	5,926​	Angiotensin- converting enzyme intolerant patients with cardiovascular disease or diabetes with end-organ damage​	Telmisartan (80 mg)​	80 mg​	Placebo​	56​	80​	3.73​
PROFESS​	20,332​	Recent (<90 days) ischemic stroke​	Telmisartan (80 mg)​	80 mg​	Placebo​	30​	70​	1.75​

Do you think it’s possible that some of the people in this study had been suffering from high blood pressure for a long time and that was in fact the cause of the cancer and not the ARBs. It seems like there is no real way to know if it’s the ARBs or the lifetime of hypertension that is the cause. I’m still going to take telmasrtin though because I feel like absolute dog shit when I have high blood pressure. It reminds me of a conversation I had with a buddy of mine. We decided that Pringle’s were so good, they could re-name them Cancer Crisps, and people would still buy that crap! Lol. We were not high btw!

 

[Fleezy]

On Lisinopril 40mg currently

Adding 5mg amlodipine on top of that today. Blood pressure was like 132/85, so trying to get that back in line

5’9 around 275lbs currently

 

[stevecleves]

It seems like there is no real way to know if it’s the ARBs or the lifetime of hypertension that is the cause.

I would agree with that. Note this line "the effects of patient characteristics such as age and smoking status could not be examined due to lack of patient-level data"
I was just highlighting that there is some evidence linking ARB exposure to cancer out there.

FWIW I currently take Telmisartan 40mg qd. I don't plan on stopping until my on hand supply runs out and after that I will probably switch to an ace inhibitor.

 

[nothuman]

Theres this:

Risk of cancer with angiotensin-receptor blockers increases with increasing cumulative exposure: Meta-regression analysis of randomized trials

Angiotensin-receptor blockers (ARBs) are a class of drugs approved for the treatment of several common conditions, such as hypertension and heart failure. Recently, regulatory agencies have started to identify possibly carcinogenic nitrosamines and azido ...

www.ncbi.nlm.nih.gov

The three Telmisartan specific studies that were part of the meta analysis were 80mg a day.

Study Name​	Total n​	Condition Studied​	ARB used (dose received a)​	Recommended daily high dose of the ARB studied b​	Control Drug (dose received a)​	Duration of follow-up (months)​	Adherence to Study Drugs (%)​	Average Cumulative Exposure to ARB (years of daily high dose)​
ONTARGET​	25,620​	Cardiovascular disease or diabetes with end-organ damage​	Telmisartan (80 mg) or Telmisartan (80 mg) + Ramipril (10 mg)​	80 mg​	Ramipril (10 mg)​	56​	80​	3.73​
TRANSCEND​	5,926​	Angiotensin- converting enzyme intolerant patients with cardiovascular disease or diabetes with end-organ damage​	Telmisartan (80 mg)​	80 mg​	Placebo​	56​	80​	3.73​
PROFESS​	20,332​	Recent (<90 days) ischemic stroke​	Telmisartan (80 mg)​	80 mg​	Placebo​	30​	70​	1.75​

Good find and fairly recent too. I’m very pro Telmisartan but this is certainly worth looking at.

 

[primobolan]

I see the Telmisartan mania comparable to the blood letting mania that swept thru the boards several years ago. It was the answer until it wasn't.

 

[machinemind]

Here’s an article that says high blood pressure meds does in fact damage the kidneys. Any drug that inhibits the renin-angiotensin system particularly angiotensin-converting enzyme (ACE) inhibitors such as linopril and angiotensin II receptor blockers (ARBs) such as telmisartan can damage the renin cells in the kidneys. “They found that specialized kidney cells called renin cells play an important role. These cells normally produce renin, a vital hormone that helps the body regulate blood pressure. But harmful changes in the renin cells can cause the cells to invade the walls of the kidney's blood vessels. The renin cells then trigger a buildup of another cell type, smooth muscle cells, that cause the vessels to thicken and stiffen. The result: Blood can't flow through the kidney as it should.”

Long-term use of blood pressure drugs may cause kidney damage, study suggests

New kidney research is raising concerns that long-term use of ACE inhibitors and other drugs commonly prescribed to treat high-blood pressure and heart failure could be contributing to kidney damage.

www.sciencedaily.com

This is an ACE thing, not an ARB thing. And ACE's only cause renal dysfunction as a rare side effect or if there is pre-existing kidney dysfunction. Think Lisinopril, "prils", not "-artans"

 

[nothuman]

I see the Telmisartan mania comparable to the blood letting mania that swept thru the boards several years ago. It was the answer until it wasn't.

Not a good comparison. Telmisartan is backed by mountains of evidence. Blood letting has no positive evidence of preventing cardiovascular issues in TRT patients.