cryptasm said:
prolonged use or abuse??? 30-40mcgs per day or is it abuse 100+mcgs pd that is associated with cardiac damage??
Basically, prolonged use of exogenous T3 results in thyrotoxicosis or an approximation of Grave's Disease. The affects are likely dose and duration dependent. Beyond that, I won't even try to guess at how much is too much and how long is too long. If anybody gives you a number, it is a guess.
Here are the manifestations of Grave's Disease (this is when your thyroid pumps out too much T3 basically)
Table 10-6. Cardiac Manifestation of Graves' Disease
- Tachycardia
- LVH and strain on EKG
- Premature atrial and ventricular contractions
- Atrial fibrillation
- Congestive heart failure
- Angina with (or without) coronary artery disease
- Myocardial infarction
- Systemic embolization
- Death from cardiovascular collapse
- Resistance to some drug effects (digoxin, coumadin)
- Residual cardiomegaly
In the absence of congenital heart defects or coronary heart disease, I think the main one for bodybuilders to be concerned with is Congestive Heart Failure and Residual Cardiomegaly. These are closey related.
When you are on gear, you are stimulating muscle growth (hopefully). Your heart is a big muscle and it will grow in response to the load being placed on it.
But, when you are on gear, it may grow too much. Adding T3 causes stronger heart contractions and tachycardia (faster heart rate), which is a recipe for cardiomegaly (enlarged heart). The problem is that there comes a point where your heart becomes less effiecient as it gets larger. As it becomes less efficient but you still place demands on it, it tries to compensate for these demands by growing larger even more. This is a vicious cycle that ends up in congestive heart failure.
Also, as the heart becomes increasingly dysmorphic (mishapen), it is less precise in conducting the elctrical current accross its mass to produce a "correct" contraction. This is when you see these athletes drop dead on the court or field. Their heart misses a beat, gets confused and basically stops beating (this is bad). My friend's son just died before Christmas at 21 years old from this. He had no symptoms but lifted pretty heavy and was not on gear at about 235lbs. He was watching TV late one night and his heart just stopped. They found him sitting on the couch, dead, the next morning. He had a congenital problem that resulted in his cardiomegaly and if caught earlier he would of been on a heart transplant list.
Anyway, as with anything else we do on this board, it is your call. It is hard for me to imagine why you would use T3 unless it was for contest prep. And, then only for short periods of time and only if you have had an EKG, a stress test and no family history of heart disease. But that is just me.
Play safe.