Nothing? Pulled up a pdf for me.The link doesn’t provide any information. Can you copy/paste it.
Nothing? Pulled up a pdf for me.The link doesn’t provide any information. Can you copy/paste it.
really interesting article - interesting and the research showed that MENT aromatizes to a very small extent only in 0.03% - so I wonder what causes it to cause so much water retention - it's possible that it has some effect on estrogen receptors, which causes symptoms of aromatizationhttps://web.archive.org/web/2020031....fi/bitstream/handle/10138/20228/7alphame.pdf
found this 2000 study on MENT lots of great information.
really interesting article - interesting and the research showed that MENT aromatizes to a very small extent only in 0.03% - so I wonder what causes it to cause so much water retention - it's possible that it has some effect on estrogen receptors, which causes symptoms of aromatization
Well this probably explains why estradiol doesn't really change if you get your level tested on itreally interesting article - interesting and the research showed that MENT aromatizes to a very small extent only in 0.03% - so I wonder what causes it to cause so much water retention - it's possible that it has some effect on estrogen receptors, which causes symptoms of aromatization
Perhaps we can theorize that arimidex or aromasin don't work well on ment because they only work on lowering the estradiol level, which ment does not increase?you use a lot of testosterone on MENT, maybe you would try dropping it and just see how much ment aromatizes alone? myself and @Mike Arnold beleive arimidex and aromasin don't work on MENT estrogen as well.
Wow, this is the most thorough information I've seen on MENT. The trials were dosages anywhere from 0.5mg to 8mg, injectable and pellet implants.https://web.archive.org/web/2020031....fi/bitstream/handle/10138/20228/7alphame.pdf
found this 2000 study on MENT lots of great information.
No I still think Ment aromatizes and it’s potent estrogen , but it can’t be controlled bc it’s converts to methyl estradiol via the liver and not adipose tissue.Perhaps we can theorize that arimidex or aromasin don't work well on ment because they only work on lowering the estradiol level, which ment does not increase?
Ment converts to methyl estradiol like dbol so aromasin or arimidex will work fine, also one thing we dont know is how much cross receptor activation is there, like with anadrol wich is a DHT so it cant aromatize yet it causes gyno, i have talked with Scott Stevenson about this several times.
Yes I'm using a tab split twice per weekAnyone use caber for trest?
If I remember correctly stradiol is prescribed at a very low dose half a mg? Or 1mg? And since ment will aromatize into the 7alpha methyl stradiol it wouldn't take much to have a strong effect on the body, similar to checke dropsreally interesting article - interesting and the research showed that MENT aromatizes to a very small extent only in 0.03% - so I wonder what causes it to cause so much water retention - it's possible that it has some effect on estrogen receptors, which causes symptoms of aromatization
Ah now i get it, so you dont think the aromatase inhibitors we know does much here, but since the cyp450arom normally isnt present in a otherwise healthy liver, do we know how much conversion actually happens via the cyp450 monooxygenase ?The aromatase reaction is a complex, multi-step pathway involving a number of enzymatic reactions.7 It is present in many different tissue types (brain, ovary, adipose, placenta, etc.) and across many different species (human, horse, pig, etc.).10-13 In fact, even certain bacteria are capable of aromatizing androgens.7 In part, solving the hypothesis regarding any possible interaction of nandrolone with the aromatase reaction has been muddied by studying the enzyme system using vastly different sources. It is known that the aromatase enzyme (cytochrome p450arom) varies greatly. Bacterial aromatase has little similarity to mammalian aromatase. Among animals, there are distinct differences between pigs, horses and man that make translating results from one species to the others difficult.7,10,11,14 Further, it has been shown that even within a single species, there are different promoters (signals that “turn on” enzyme production) in different tissues.12 Conditions that may promote aromatization in the testes are different from those of fat cells.
In mammals, the aromatase reaction involves two separate enzymes that are jointly involved in converting androgens into estrogens.7,12 The first, the hemoprotein CYParom encoded by the CYP19 gene (for those of you who need that kind of information), is the catalyst. It attacks the 19-carbon in two steps and the nearby 1-carbon by oxidizing the androgen molecule at those points. The resulting response and actions of the second enzyme (NADPH-cytochrome P450 reductase) cause the loss of the 19-carbon and the simultaneous generation of a phenolic A-ring (a defining feature of an estrogen). In the absence of a 19-carbon, such as in nandrolone, the reaction would be much less efficient if it was even able to function.
Many medico-scientific journals have noted nandrolone to be a non-aromatizable AAS. Studies using brain cells have shown nandrolone to be more neurotoxic (damaging to nerve cells) because it is not aromatized. It is true that nandrolone is not a candidate for classic aromatization, as the 19-carbon that is missing from nandrolone is the starting point for the entire aromatase reaction. Interestingly, nandrolone stimulates aromatase in rat models, even though it does not participate in the reaction. This would accelerate the conversion of other androgens (testosterone, D-bol, etc).
Yet, the results of a recent study published in the Climacteric prove that nandrolone and other 19-nortestosterone-derived steroids can be converted into estrogenic steroids through a series of enzymatic reactions that take place in the human liver.15 The catalytic (accelerating) first enzyme, CYP 450arom, is not present in the adult human liver, though CYP 450arom is present in certain liver diseases and tumors. However, another enzyme called CYP 450 monooxygenase is able to attack the 2-carbon of the nandrolone and begin the generation of the phenolic A-ring…the definitive step in converting an androgen (or 19-norandrogen in this case) into an estrogen.
Ah now i get it, so you dont think the aromatase inhibitors we know does much here, but since the cyp450arom normally isnt present in a otherwise healthy liver, do we know how much conversion actually happens via the cyp450 monooxygenase ?
To be clear, is the tab 0.5mg? So 0.25mg twice a weekYes I'm using a tab split twice per week