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Use of insulin and life expectancy

Beti ona

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Insulin use and increased risk of mortality in type 2 diabetes: a cohort study:

https://www.ncbi.nlm.nih.gov/pubmed/19788429

Glucose-lowering with exogenous insulin monotherapy in type 2 diabetes: dose association with all-cause mortality, cardiovascular events and cancer:

https://www.ncbi.nlm.nih.gov/pubmed/25399739

Insulin administration may trigger type 1 diabetes in Japanese type 2 diabetes patients with type 1 diabetes high-risk HLA class II and the insulin gene VNTR genotype:

https://www.ncbi.nlm.nih.gov/pubmed/24971665
 

goal245

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Here are some studies showing the opposite:

Insulin pump reduces mortality from cardiovascular disease by almost 50%

https://www.sciencedaily.com/releases/2015/08/150811092042.htm


Continuous insulin infusion reduces mortality in patients with diabetes undergoing coronary artery bypass grafting.

https://www.ncbi.nlm.nih.gov/pubmed/12771873

Combining metformin with insulin reduces mortality in Type 2 diabetes: Study


https://www.fiercepharma.com/drug-d...sulin-reduces-mortality-type-2-diabetes-study

Long-term insulin glargine therapy in type 2 diabetes mellitus: a focus on cardiovascular outcomes

The association of hyperinsulinemia with increased cardiovascular risk has led to a justifiable concern that exogenous insulin administration could increase the incidence of cardiovascular events in patients with type 1 and type 2 diabetes. Insulin has been shown to have both cardioprotective and atherosclerosis-promoting effects in laboratory animal studies. However, human trials have not shown insulin to increase cardiovascular event rates. Indeed, intensive diabetes control using insulin in type 1 diabetes patients in EDIC, or insulin or a sulfonylurea in type 2 diabetes patients in UKPDS led to improved long-term cardiovascular outcomes. Such data support the concept that hyperinsulinemia is a marker of insulin resistance, a condition associated with numerous cardiovascular risk factors and increased cardiovascular risk, rather than exogenous insulin being a risk factor for cardiovascular disease. Glargine lowers TG, leads to a modest weight gain, decreases hypoglycemia when compared with NPH, and has a neutral effect on blood pressure. The ORIGIN trial, a dedicated cardiovascular outcomes trial of glargine, demonstrated no increased cardiovascular risk.

Contemporary clinical diabetes trials routinely employ greater cardiovascular risk factor control, especially of elevated lipids and blood pressure, and are therefore expected to have lower background cardiovascular event rates. For this reason, future definitive cardiovascular outcomes trials of anti-hyperglycemic agents may need to be extended beyond 5–6 years.

Randomized trials of intensive therapy in type 2 diabetes with high rates of insulin use have demonstrated an association of severe hypoglycemia and adverse cardiovascular events. Whether hypoglycemia is contributing the increased cardiovascular risk or simply a marker of a more ill, higher risk patient population remains controversial. Clinicians should be aware of the hypoglycemic risk of all insulins, and should work to minimize hypoglycemia especially in higher risk patients.
 

asteelz

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Goal your studies have nothing to do with the ops post.. your studies are about acute glucose mitigation during a cabg and a pump use in diabetics..

Anyway..

Higher levels of circulating insulin are correlated with a shorter life expectancy. There’s no debating this. As I’ve discussed on this board in regards to insulin use in bodybuilding, keep it in short intervals around workouts. Chronically
Elevated levels are what lead to the greatest health consequences.
 

buck

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Pretty much all the studies I see show people that use insulin have shorter life expediencies then those that don't use it.
 

IronLion2

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Pretty much all the studies I see show people that use insulin have shorter life expediencies then those that don't use it.

I mean, the majority of insulin users are diabetics so yeah..... But whats the strength of correlation between diabetics and bb'er dose/use? Probably comparable, but we'll never get that in a medical study.
 

goal245

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"There was an association between increasing exogenous insulin dose and increased risk of all-cause mortality, MACE and cancer in people with type 2 diabetes. The limitations of observational studies mean that this should be further investigated using an interventional study design."

ALSO THIS WAS AN OBSERVATIONAL STUDY

I think the important question to ask is WHY was the insulin dose increased?

Most likely because the person kept eating bad/doing what caused the diabetes in the first place hence requiring the higher insulin dose.

Of course someone eating bad/not exercising will need more insulin and will die faster compared to someone who is watching their diet/excising and requires less insulin
 

goal245

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Goal your studies have nothing to do with the ops post.. your studies are about acute glucose mitigation during a cabg and a pump use in diabetics..

Anyway..

Higher levels of circulating insulin are correlated with a shorter life expectancy. There’s no debating this. As I’ve discussed on this board in regards to insulin use in bodybuilding, keep it in short intervals around workouts. Chronically
Elevated levels are what lead to the greatest health consequences.

Would you agree that insulin dose and the amount we eat is correlated?

For example someone can't be eating 2000 calories while taking 200iu of insulin per day but someone eating 6000 calories could be taking 200iu of insulin. So is it the insulin or the calories that will lead to problems?

if we don't overeat then there is a limit to how much insulin we can use

It's impossible to abuse insulin without also abusing calories/food
 
Last edited:

Beti ona

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if we don't overeat then there is a limit to how much insulin we can use

It's impossible to abuse insulin without also abusing calories/food

It is not question of calories, it is a question of the quality of those calories.

If you eat 2000 calories of sugar you will need a lot of insulin.
 

goal245

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It is not question of calories, it is a question of the quality of those calories.

If you eat 2000 calories of sugar you will need a lot of insulin.

Generally speaking overall chronic calories matter a lot when it comes to insulin levels/resistance. 6000 calories will have side effects with or without insulin even if all the calories are from good sources.

Ever heard of Fruitarianism? they eat lots of sugar from fruits but calories are within reason

In 1971, a short-term study by B. J. Meyer was published in the South African Medical Journal[19] describing how lipid profiles and glucose tolerances improved on a particular fruitarian diet.[20] In a further trial in the study, body weights of overweight subjects showed a tendency to "level off" at the "'theoretically ideal' weight".[21]
 

goal245

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It is not question of calories, it is a question of the quality of those calories.

If you eat 2000 calories of sugar you will need a lot of insulin.

Populations that live the longest have 2 things in common, low calories under 1500 (mostly coming from carbs), and low stress.

Wanna live long? eat as little as possible and be as light as possible, but who wants to live like a monk?
 

IsaacHaze1

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i don't think you really need to cite any study to know increasing systemic inflammation is not a good thing for longevity.
 

asteelz

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Fair.. goal I see what your gettig at. I prefer to look at the biochemical system
Rather than the biochemical substrate. I can lower insulin by changing the diet or by making the cells more sensitive. Either way there is less of it in the system. The system with less substrate does not have to work as hard, but also can’t put out as much “work” or force.
 

maldorf

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powerof2

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Would you agree that insulin dose and the amount we eat is correlated?



For example someone can't be eating 2000 calories while taking 200iu of insulin per day but someone eating 6000 calories could be taking 200iu of insulin. So is it the insulin or the calories that will lead to problems?



if we don't overeat then there is a limit to how much insulin we can use



It's impossible to abuse insulin without also abusing calories/food



I agree with u on this one. Make sense to give the pancreas a break. Ur body has to produce x amount of insulin to clear x amount in the blood stream. It can’t stop until it clears what it has to be in balance. Using insulin definitely can give the break a pancreas instead of burning it out.


Sent from my iPhone using Tapatalk
 

Beti ona

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Populations that live the longest have 2 things in common, low calories under 1500 (mostly coming from carbs), and low stress.

Wanna live long? eat as little as possible and be as light as possible, but who wants to live like a monk?

IF plus Low calories plus low carbohydrates is the winning combination. If you also add exercise and absence of stress, it will be even better.

Live like a monk? That is not the question, but keep in mind that if you use insulin, you are reducing your life.

There are a lot of bitches who will abuse insulin, then they will become diabetic and start crying. Just be a man, inform yourself, decide, and accept the consequences.
 
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