Mike Arnold
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Letro destroys my sex drive EVEN IF E2 IS IN RANGE. This has been theorized as a side effect of letro acting directly on certain brain specific aromatase that other AIs don't reach. I believe this one of the reasons letro gets the reputation of being stronger than other AIs, when it is not.
High dose deca seems to have some effect.
Any cycle that goes over 2g seems to have an effect.
Remember, androgens block out estrogens (due to co-binding factors that compete for the ER and AR), so if you have enough androgen in your system, the effects of estrogen will be low even if you have a lot of estrogen in your system.
SHBG may be involved also. SHBG is NOT what the dogma says, it an active transport mechanism that grabs sex hormones and actively transports them into the cell to the AR and ER. Look up "SHBG membrane receptor" to learn more about what SHBG really does.
I first heard about this about 6-8 months ago...and realized I have at least 3-4 articles that provide incorrect information on SHBG. Very interesting topic.