I've never understood the mentality that its justified to 'push it' if you are making a living from this. What good is success in any endeavor if you are not there to enjoy it or you are too unhealthy to feel good?
With that said, as a non competitor, I just set limits for what I am willing to take and I monitor my health as best as possible. There is no 'job to get done' in my case, I just try and make as much progress as I can while doing what I consider safe/sane doses of particular drugs.
For me personally, that means no orals (lipids, worry about hematomas) or slin (the weight gain associated with it is not healthy for me), no arimidex (lipids), very limited 19-nor use (I feel they are much harder on cardiovascular system), and more focus on what I consider safer drugs (test, primo, and some masteron). I think what is considered safe is going to vary from person to person. My 'program' is based on my own reaction to drugs; how I physically feel, my bloodwork results, and my own research (such as the study showing nandralone to be 10x more damaging to blood vessels than test).
I believe that it is safer to use increased doses of hormones your body already makes (like test, DHT, GH) than it is to use completely synthetic drugs like tren.
Of course I would rather not work with these self imposed limitations, but this is the best compromise I could come up with; getting results without stressing about what I am doing to my body.
If I was willing to push it, I would be using a lot of tren, NPP, and orals. They give me the best results, but definitely at a cost. I am envious of those that can use them and still have good blood work.
I also worry about the negative health effects that go on behind the scenes. If bloodwork checks out, you could still have a clot form, have a heart attack, have blockage you didn't know about, etc.