How much you know about microbiomes? Eating fast food(junk foods) can alter your microbiome.
Gut microbiota changes and its potential relations with thyroid carcinoma
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XiaqingYua1WenJianga1Russell OliverKosika1YingchunSongaQiongLuoaTingtingQiaoaJunyuTongaSiminLiuaChengwenDengaShanshanQinaZhongweiLvabcDanLiab
Highlights
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Thyroid cancer patients have reduced richness and diversity of gut microbiota.
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A predictive model of 10 genera could distinguish thyroid cancer patients from healthy controls.
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The loss of the short-chain fatty acid-producing bacteria may promote thyroid carcinoma.
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The functional changes that occur in thyroid cancer patients affect the processing of genetic information.
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A four-genus microbial signature may be able to distinguish thyroid carcinoma patients with metastatic lymphadenopathy from those without metastatic lymphadenopathy.
Results
In the exploratory cohorts, TCs had reduced richness and diversity of gut microbiota compared to HCs. No significant difference was found between TCs and HCs on the phylum level, though 70% of TCs had increased levels of
Proteobacteria-types based on dominant microbiota typing. A prediction model of 10 genera generated with LEfSe analysis and lasso regression distinguished TCs from HCs with areas under the curves of 0.809 and 0.746 in the exploration and validation cohorts respectively. Functional prediction suggested that the microbial changes observed in TCs resulted in a decline in aminoacyl-tRNA biosynthesis, homologous recombination, mismatch repair, DNA replication, and nucleotide excision repair. A four-genus microbial signature was able to distinguish TC patients with metastatic lymphadenopathy from those without metastatic lymphadenopathy.
Conclusion
Our study shows that thyroid carcinoma patients demonstrate significant changes in gut microbiota, which will help delineate the relationship between gut microbiota and TC pathogenesis.