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Creatine raises DHT:T ratio?

Jugghead

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Dec 23, 2006
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I was browsing another BB forum and I came across this study. Anyone ever heard of this?

Clinical Journal of Sport Medicine
Issue: Volume 19(5), September 2009, pg. 399-404

Three Weeks of Creatine Monohydrate Supplementation Affects Dihydrotestosterone to Testosterone Ratio in College-Aged Rugby Players

Abstract

Objective: This study investigated resting concentrations of selected androgens after 3 weeks of creatine supplementation in male rugby players. It was hypothesized that the ratio of dihydrotestosterone (DHT, a biologically more active androgen) to testosterone (T) would change with creatine supplementation.

Design: Double-blind placebo-controlled crossover study with a 6-week washout period.

Setting: Rugby Institute in South Africa.

Participants: College-aged rugby players (n = 20) volunteered for the study, which took place during the competitive season.

Interventions: Subjects loaded with creatine (25 g/day creatine with 25 g/day glucose) or placebo (50 g/day glucose) for 7 days followed by 14 days of maintenance (5 g/day creatine with 25 g/day glucose or 30 g/day glucose placebo).

Main Outcome Measures: Serum T and DHT were measured and ratio calculated at baseline and after 7 days and 21 days of creatine supplementation (or placebo). Body composition measurements were taken at each time point.

Results: After 7 days of creatine loading, or a further 14 days of creatine maintenance dose, serum T levels did not change. However, levels of DHT increased by 56% after 7 days of creatine loading and remained 40% above baseline after 14 days maintenance (P < 0.001). The ratio of DHT:T also increased by 36% after 7 days creatine supplementation and remained elevated by 22% after the maintenance dose (P < 0.01).

Conclusions: Creatine supplementation may, in part, act through an increased rate of conversion of T to DHT. Further investigation is warranted as a result of the high frequency of individuals using creatine supplementation and the long-term safety of alterations in circulating androgen composition.

Statement of Clinical Relevance: Although creatine is a widely used ergogenic aid, the mechanisms of action are incompletely understood, particularly in relation to dihydrotestosterone, and therefore the long-term clinical safety cannot be guaranteed.

Very interesting!
 

StealthwHealth

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Aug 31, 2010
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Wow, after being the most studied sports supplement ever, they barely figure this out?! This could definitely change a lot of people's creatine supplementing regimen if this is the case.

Speaking of DHT, where the hell did I put my drol...:D
 

Kaladryn

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serum T levels did not change...Creatine supplementation may, in part, act through an increased rate of conversion of T to DHT
Wouldn't this cause decreased levels of test? It seems more likely that creatine is keeping DHT from being metabolized somehow.
 

UGAthlete

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Feb 25, 2008
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I don't really see how this could be a direct result of creatine supplementation.. maybe as a secondary effect from the accelerated gains?

Hopefully somebody with more knowledge on the subject will chime in.
 

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