I have also been injecting HGH (IV instead of subq for increase bioavaila- bility) for the past 12 months. I would like to warn people with coronary problems about the one potentially serious side effect of HGH use. The water retension from HGH is due to increased secretion of ADH (anti- diuretic hormone) from the posterior pituitary. This hormonal relationship is not in any medical literature. However, it must be true, because the water retension and hypertension are easily controlled by .2mg of clonidine q 12 hours (personal experience). Clonidine's primary action is retarding ADH secretion. ACE inhibitors have no effect, which means that angiotensin and sodium retention are not part of the problem.