Janoshik Interview. HGH myths, UGL clen, Insulin disguised as GLP'S.

[bigains]

Okay, so I watched the GH part at about halfway in. He's saying most samples sent in are actually way better than what is required to claim a pharmaceutical standard. But the question is again, if all is "pharma," why the persistent debate over China GH vs well established brands like Genotropin. I guess what I wanted to hear is that in this guys view is the China growth still deficient in some way, e.g. is Geno better? I know this has been debated ad nauseum but just the other day that 20.000ng test level guys, Chase something, raved about how much better Serostim was vs generic, says you can tell big positive changes within a week when switching to Sero, said he used generic for 8 years and it wasn't doing much at all. Thoughts (again)?

My thoughts on the difference between different brands of gh is the amount of mannitol used as an excipient, given the gh is of a high purity. Mannitol is a diuretic. Serostim has no mannitol and is fda approved for weight gain in people with HIV. A 12 mg genotropin pen has 46 mg mannitol and is used for growth in children where water retention would be seen as a negative side effect. So the serostim should give more fullness and the genotropin should give a dryer look. With generics the purity may be similar or meet pharma standards, but only the manufacturer knows how much mannitol is used. So it would be more of a gamble for some coaches to recommend generic gh going into a show unless the client is using the same batch of gh. And the coach dials the dose in based on the look.

 

[pickapeck]

Great interview. Janoshik earned my respect.

 

[tommyguns2]

Are you even listening to yourself lol, that's the right...the feds are lazy and would go after steroid dealers than cartels simply for that reason. You need to find a new hobby. It's actually quite the opposite.

Great first post. Completely unintelligible.

 

[specter]

My thoughts on the difference between different brands of gh is the amount of mannitol used as an excipient, given the gh is of a high purity. Mannitol is a diuretic. Serostim has no mannitol and is fda approved for weight gain in people with HIV. A 12 mg genotropin pen has 46 mg mannitol and is used for growth in children where water retention would be seen as a negative side effect. So the serostim should give more fullness and the genotropin should give a dryer look. With generics the purity may be similar or meet pharma standards, but only the manufacturer knows how much mannitol is used. So it would be more of a gamble for some coaches to recommend generic gh going into a show unless the client is using the same batch of gh. And the coach dials the dose in based on the look.

i was trying to find something about mannitol being used as a diuretic yesterday and all i could find was when it was fluid in the brain etc and doses where far beyond 46mg, do we know that low a dose actually has any diuretic effect at all ?

 

[aHarness]

i was trying to find something about mannitol being used as a diuretic yesterday and all i could find was when it was fluid in the brain etc and doses where far beyond 46mg, do we know that low a dose actually has any diuretic effect at all ?

I’ve said this multiple times, but I truly don’t believe (for the same reason as you) the mannitol in pharma gh or some of @theprovider products is enough for any diuretic effect

 

[Massive G]

I always find it interesting how people react to GH. I didn't start GH until 2004 after 15 years of training. Didn't really plan it it just kind of fell in me lap. A guy was selling unused serokits prescribed to HIV patients for $100 each. Seros will always be my first love damn the paralyzed arms and all the bloat be dammed. Jintropins were next as it was hugely popular around that time before the US government conspired with China to shut down Genescience. I next tried original Riptropins and Hygetropins which were both the same product, just blue cap for riptropin and brown for hygetropin. Reminded me of seros, tons of bloat and nerve pain. Also got some really strong sometimes irregular heart beats. Still, they worked very well.
I will say there was some crappy brands out there for a while for those that remember the kigtropin scam and blue tops that left people with painful itchy welts.
The quality of GH has really improved over that time due to modern production methods and financial backing. There still is some bunk stuff out there. But the blacks and mauves are really good. I still get a strong beat or 2 but nothing like before in 2010. The only thing that bugs me and others is the lethargy at times so my dose is pretty low.
That's why we appreciate jano and the service he provides on testing for peace of mind and accurate dosing.

 

[bigains]

i was trying to find something about mannitol being used as a diuretic yesterday and all i could find was when it was fluid in the brain etc and doses where far beyond 46mg, do we know that low a dose actually has any diuretic effect at all ?

I know each individuals results will vary but I tried a bit of an experiment on myself after hearing some people on YouTube talk about mannitol in gh being used as a diuretic to reduce water retention as well as stabilizing gh to some extent. For me the gh I have used gives me more water retention than I want at any reasonable dose. I mixed up some reagent grade ultra pure mannitol at 25mg/ml in normal saline and added 1.5%ba then filtered it into a vial. I have been using it to dilute my generic gh from qsc sold as 10iu vials but is closer to 12iu. Prior to using the mannitol solution 2-4iu a day was giving me some pitting edema on my lower legs along my shin. After using the mannitol solution I no longer get pitting edema using 2-4iu. So it worked for me to decrease the edema I get from the gh I am using. While the mannitol reduced the edema, I am no longer getting as much fullness inside the muscle I was getting from this dose of gh prior to using the mannitol solution. So I think there is a trade off. But I think it will allow me to use more gh without too much water retention. It could possibly be the reason I have heard some people on podcasts say humatrope and genotropin keep a person dryer than serostim or some random Chinese gh. I really don't see any other ingredient on the packaging that should make any difference. There really aren't any guarantees that it will work the same in everyone though.

 

[bigains]

i was trying to find something about mannitol being used as a diuretic yesterday and all i could find was when it was fluid in the brain etc and doses where far beyond 46mg, do we know that low a dose actually has any diuretic effect at all ?

I’ve said this multiple times, but I truly don’t believe (for the same reason as you) the mannitol in pharma gh or some of @theprovider products is enough for any diuretic effect

I really do understand the scepticism because like you said it is a very small amount of mannitol.

 

[aHarness]

I know each individuals results will vary but I tried a bit of an experiment on myself after hearing some people on YouTube talk about mannitol in gh being used as a diuretic to reduce water retention as well as stabilizing gh to some extent. For me the gh I have used gives me more water retention than I want at any reasonable dose. I mixed up some reagent grade ultra pure mannitol at 25mg/ml in normal saline and added 1.5%ba then filtered it into a vial. I have been using it to dilute my generic gh from qsc sold as 10iu vials but is closer to 12iu. Prior to using the mannitol solution 2-4iu a day was giving me some pitting edema on my lower legs along my shin. After using the mannitol solution I no longer get pitting edema using 2-4iu. So it worked for me to decrease the edema I get from the gh I am using. While the mannitol reduced the edema, I am no longer getting as much fullness inside the muscle I was getting from this dose of gh prior to using the mannitol solution. So I think there is a trade off. But I think it will allow me to use more gh without too much water retention. It could possibly be the reason I have heard some people on podcasts say humatrope and genotropin keep a person dryer than serostim or some random Chinese gh. I really don't see any other ingredient on the packaging that should make any difference. There really aren't any guarantees that it will work the same in everyone though.

Why not use something more standard like HCTZ?

 

[bbxtreme]

I’ve said this multiple times, but I truly don’t believe (for the same reason as you) the mannitol in pharma gh or some of @theprovider products is enough for any diuretic effect

I don’t personally buy into the mannitol either. However, I bumped HGH up to 15iu recently using TP’s as I had them on hand. I had significant water weight gain and bloating. Just for fun I split my dosage and used Geno pens for half to try and offset. The water and all dropped. Which can cause a spike in RHR and BP.

Do I think Geno’s are more effective than TP? Absolutely not. I plan to stock up this week when TP is restocked. However, I can’t explain the water weight difference between them and Geno pens, but it’s there as I am a numbers guy.

While I have money, I’d still choose TP’s unless you’re in an active top level prep as there’s no difference. Save your money and offset any water (if needed) other ways.

Just my experience…

 

[aHarness]

I don’t personally buy into the mannitol either. However, I bumped HGH up to 15iu recently using TP’s as I had them on hand. I had significant water weight gain and bloating. Just for fun I split my dosage and used Geno pens for half to try and offset. The water and all dropped. Which can cause a spike in RHR and BP.

Do I think Geno’s are more effective than TP? Absolutely not. I plan to stock up this week when TP is restocked. However, I can’t explain the water weight difference between them and Geno pens, but it’s there as I am a numbers guy.

While I have money, I’d still choose TP’s unless you’re in an active top level prep as there’s no difference. Save your money and offset any water (if needed) other ways.

Just my experience…

Makes me wonder if Genos specifically do have enough added mannitol as perhaps during formulation edema was taken into consideration. However I definitely agree, there are better options as we have very cheap ways to manage water retention.

 

[bbxtreme]

Makes me wonder if Genos specifically do have enough added mannitol as perhaps during formulation edema was taken into consideration. However I definitely agree, there are better options as we have very cheap ways to manage water retention.

Trust me, I have money, but Geno’s are extremely expensive and hard to get currently. I’m pushing on everyone I know to give me a solid answer. lol

Maybe one of the smarter minds on here can chime in or @janoshik has an analysis on the breakdown.

 

[pickapeck]

I know each individuals results will vary but I tried a bit of an experiment on myself after hearing some people on YouTube talk about mannitol in gh being used as a diuretic to reduce water retention as well as stabilizing gh to some extent. For me the gh I have used gives me more water retention than I want at any reasonable dose. I mixed up some reagent grade ultra pure mannitol at 25mg/ml in normal saline and added 1.5%ba then filtered it into a vial. I have been using it to dilute my generic gh from qsc sold as 10iu vials but is closer to 12iu. Prior to using the mannitol solution 2-4iu a day was giving me some pitting edema on my lower legs along my shin. After using the mannitol solution I no longer get pitting edema using 2-4iu. So it worked for me to decrease the edema I get from the gh I am using. While the mannitol reduced the edema, I am no longer getting as much fullness inside the muscle I was getting from this dose of gh prior to using the mannitol solution. So I think there is a trade off. But I think it will allow me to use more gh without too much water retention. It could possibly be the reason I have heard some people on podcasts say humatrope and genotropin keep a person dryer than serostim or some random Chinese gh. I really don't see any other ingredient on the packaging that should make any difference. There really aren't any guarantees that it will work the same in everyone though.

Just an idea, when I used saline instead of bac water i noticed a drop off in fullness. You might try going to bac water instead and see if that makes a difference. The mannitol should act as osmotic support so saline may not be needed.

 

[specter]

i have a friend who worked at Novo Nordisk ill ask him about the mannitol.

 

[aHarness]

i have a friend who worked at Novo Nordisk ill ask him about the mannitol.

Genos are by Pfizer. I don’t believe Novo Nordisk Norditropin has any mannitol.

 

[specter]

Genos are by Pfizer. I don’t believe Novo Nordisk Norditropin has any mannitol.

Content of Norditropin
Konservering

Phenol

Andre

Histidin

Mannitol E-421

Natriumhydroxid E524

Poloxamer

Saltsyre E507

Sterilt vand

 

[rAJJIN]

I wonder if it’s formula related or dosage related? Or individual per person. It seems maybe all would be a factor.
I’ve heard many say though less water with certain brands even at equal dosage

 

[aHarness]

Content of Norditropin
Konservering

Phenol

Andre

Histidin

Mannitol E-421

Natriumhydroxid E524

Poloxamer

Saltsyre E507

Sterilt vand

New info to me. Thanks dude. My understanding was that Genos were the only pharma with mannitol.

 

[bigzzz]

I don’t personally buy into the mannitol either. However, I bumped HGH up to 15iu recently using TP’s as I had them on hand. I had significant water weight gain and bloating. Just for fun I split my dosage and used Geno pens for half to try and offset. The water and all dropped. Which can cause a spike in RHR and BP.

Do I think Geno’s are more effective than TP? Absolutely not. I plan to stock up this week when TP is restocked. However, I can’t explain the water weight difference between them and Geno pens, but it’s there as I am a numbers guy.

While I have money, I’d still choose TP’s unless you’re in an active top level prep as there’s no difference. Save your money and offset any water (if needed) other ways.

Just my experience…

What is your opinion on using something like 12.5mg of HCTZ on high doses of GH to offset some gh water?

 

[bbxtreme]

What is your opinion on using something like 12.5mg of HCTZ on high doses of GH to offset some gh water?

As long as your kidneys are healthy and electrolytes are solid I think it can be viable to accomplish that. Just keep in mind using a diuretic to pull water could be somewhat counterproductive to the fullness and benefits of HGH.

I try to avoid it as you want as much cellular hydration as possible when training. I would rather see someone just adjust their dose up slower which eliminates it in most cases. Or if you are constantly holding tons of water at the dosage you’re at, then it may be time to cut it back as not everyone responds well to higher HGH. My body loves it. I know others who can’t tolerate over 4iu.

But to answer your question directly lol yes and many guys do that as they don’t like the extra water weight.