• All new members please introduce your self here and welcome to the board:
    http://www.professionalmuscle.com/forums/showthread.php?t=259
Buy Needles And Syringes With No Prescription
M4B Store Banner
SPC-210x65
Riptropin Store banner
Generation X Bodybuilding Forum
Buy Needles And Syringes With No Prescription
Buy Needles And Syringes With No Prescription
Mysupps Store Banner
IP Gear Store Banner
Anabolic Hormones Store Banner
Ganabol Store Banner
Spend $100 and get bonus needles free at sterile syringes
Professional Muscle Store open now
LandmarkChem Email Banner
advertise1
Bruce Labs Store banner
gd
Professional Muscle Store open now
over 5000 supplements on sale at professional muscle store
granabolic123
Blackroids-animated-optimized-number-1
over 5000 supplements on sale at professional muscle store
over 5000 supplements on sale at professional muscle store
advertise1
apollo
steroidjet
kinglab
over 5000 supplements on sale at professional muscle store
over 5000 supplements on sale at professional muscle store
over 5000 supplements on sale at professional muscle store
over 5000 supplements on sale at professional muscle store
over 5000 supplements on sale at professional muscle store
over 5000 supplements on sale at professional muscle store
over 5000 supplements on sale at professional muscle store

Losartan lowers myostatin post workout in older subjects

nothuman

Featured Member / Kilo Klub
Featured Member
Kilo Klub Member
Registered
Joined
Jan 15, 2011
Messages
11,687
Blood Pressure Drug Losartan Lowers Post-Workout Myostatin Level in Older Subjects
A recent RCT investigated the effect of blocking the angiotensin II type I receptor (AT1R) upon the response to acute heavy resistance exercise in elderly human skeletal muscle.

The hypothesis was that AT1R blocking would result in a superior myogenic response accompanied by downregulation of TGF-[beta] and upregulation of IGF-1 signalling... well, not exactly what happened.

28 healthy elderly men (+64 years) were randomized into two groups, consuming either AT1R blocker (Losartan, 100mg/day) or Placebo for 18 days prior to exercise. Participants performed one bout of heavy unilateral resistance exercise. Six muscle biopsies were obtained from the vastus lateralis muscles of each subject: two before exercise, and four after exercise (4.5 hours and 1, 4 and 7 days). Blood pressure and blood samples were collected at the same time points. Biopsies were sectioned for immunohistochemistry to determine the number of satellite cells associated with type I and type II fibres. Gene expression levels of Notch, connective tissue and myogenic signalling pathways were determined by real time RT-PCR.

Changes over time were detected for circulating creatine kinase, the number of satellite cells per type I fibre and most of the gene targets, with no specific effect of losartan on these. However, when compared with placebo, Losartan intake resulted in a greater suppression of myostatin mRNA.

suppversity.com | Heisterberg, Mette Flindt; Andersen, Jesper L.; Schjerling, Peter; Bülow, Jacob; Lauersen, Jeppe Bo; Roeber, Heidi L.; Kjaer, Michael; Mackey, Abigail L. "Effect of Losartan on the Acute Response of Human Elderly Skeletal Muscle to Exercise." Medicine & Science in Sports & Exercise: Post Acceptance: October 16, 2017 - doi: 10.1249/MSS.0000000000001438
 

nothuman

Featured Member / Kilo Klub
Featured Member
Kilo Klub Member
Registered
Joined
Jan 15, 2011
Messages
11,687
I'd like to think Telmisartan does the same, hopefully in younger subjects too.
 

thatguy78

Member
Newbies
Joined
Jan 9, 2017
Messages
42
been on 100mg of losartan for 13 years, I was on the drug before losartan(generic) came out, I believe it was alvapro or something like that
 

xman280

Banned
Joined
Aug 3, 2013
Messages
647
"In rare cases, losartan can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine. [Quote, https://www.drugs.com/losartan.html ]"..what? breakdown of muscle tissue leading to renal failure??? breakdown of muscle tissue does increas creatinine temporary nut havent heard that can cause renal disease...
 

Staff online

  • Big A
    IFBB PRO/NPC JUDGE/Administrator
  • pesty4077
    Moderator/ Featured Member / Kilo Klub

Forum statistics

Total page views
508,608,546
Threads
124,773
Messages
2,406,426
Members
155,828
Latest member
tutorsindia
Top