.gif "IP Gear")
- Joined
- Jun 5, 2002
- Messages
- 791
Below are a couple of PM's that I think may help some of you who are concerned about protein in your urine.
---------- Phil's levels ----------
My creatinine levels were 1.9 and I am excreting 5300 mg protein in my urine over 24 hours.
---------- My reply ----------
Phil,
Those levels are both very, very high; the top end on normal creatinine is 1.4 mg/dL and for 24 hour protein excretion its 150 mg. It sounds like you have a bad case of Proteinuria and I would suggest you see a Nephrologist (kidney specialist) ASAP.
Proteinuria refers to the presence of protein in the urine. In healthy persons, the urine contains virtually no protein or only a trace amount of protein. Proteins in the urine are comprised of albumin and globulin from the plasma. Because albumin is filtered more easily than globulin, it is the predominant type of protein that may appear in the urine. The term albuminuria may be used interchangeably with proteinuria.
Detection of protein in the urine, combined with a microscopic exam of urinary sediment, provides the basis for the differential diagnosis of kidney disease. Normally, the glomeruli prevent passage of protein from the blood to the glomerular filtrate (the glomerulus being the filtering apparatus of the kidney). A small amount of filtered plasma proteins and proteins secreted by the nephrons can be found in normal urine; the normal range of protein excreted in a 24 hr. period is typically less than 150mg. Of this 150, 5-15 mg is albumin and the rest is composed of over thirty different types of renal proteins. Your doctor should probably have the excreted protein fractionated to determined what is causing the proteinuria. Excretion of mainly albumin may signify a glomerular lesion. Glomerular injury also causes increased permeability to plasma proteins, resulting in proteinuria. Generally though a persistent finding of proteinuria is the single most important indication of kidney disease.
Proteinuria is described based on the following scale:
Trace = less than 150 mg/24 hours (upper limit of normal)
1+ = 200 - 500 mg/24 hours
2+ = 500 - 1500 mg/24 hours
3+ = over 2500 mg/24 hours
4+ = over 3000 mg/24 hours
As you can see Phil, you are a 4+ on this scale - that concerns me greatly. Please go see someone.
DrG
P.S: Protein in the Urine is not normal. It is a symptom of something happening in your body. While the more concrete signs of kidney damage are the BUN (Blood Urea Nitrogen) and Creatine Serum Blood ratios along with the Creatine Clearance test, you still need to find out why protein is in the urine to begin with and hopefully stop more damage from occuring.
---------- Phil's levels ----------
My creatinine levels were 1.9 and I am excreting 5300 mg protein in my urine over 24 hours.
---------- My reply ----------
Phil,
Those levels are both very, very high; the top end on normal creatinine is 1.4 mg/dL and for 24 hour protein excretion its 150 mg. It sounds like you have a bad case of Proteinuria and I would suggest you see a Nephrologist (kidney specialist) ASAP.
Proteinuria refers to the presence of protein in the urine. In healthy persons, the urine contains virtually no protein or only a trace amount of protein. Proteins in the urine are comprised of albumin and globulin from the plasma. Because albumin is filtered more easily than globulin, it is the predominant type of protein that may appear in the urine. The term albuminuria may be used interchangeably with proteinuria.
Detection of protein in the urine, combined with a microscopic exam of urinary sediment, provides the basis for the differential diagnosis of kidney disease. Normally, the glomeruli prevent passage of protein from the blood to the glomerular filtrate (the glomerulus being the filtering apparatus of the kidney). A small amount of filtered plasma proteins and proteins secreted by the nephrons can be found in normal urine; the normal range of protein excreted in a 24 hr. period is typically less than 150mg. Of this 150, 5-15 mg is albumin and the rest is composed of over thirty different types of renal proteins. Your doctor should probably have the excreted protein fractionated to determined what is causing the proteinuria. Excretion of mainly albumin may signify a glomerular lesion. Glomerular injury also causes increased permeability to plasma proteins, resulting in proteinuria. Generally though a persistent finding of proteinuria is the single most important indication of kidney disease.
Proteinuria is described based on the following scale:
Trace = less than 150 mg/24 hours (upper limit of normal)
1+ = 200 - 500 mg/24 hours
2+ = 500 - 1500 mg/24 hours
3+ = over 2500 mg/24 hours
4+ = over 3000 mg/24 hours
As you can see Phil, you are a 4+ on this scale - that concerns me greatly. Please go see someone.
DrG
P.S: Protein in the Urine is not normal. It is a symptom of something happening in your body. While the more concrete signs of kidney damage are the BUN (Blood Urea Nitrogen) and Creatine Serum Blood ratios along with the Creatine Clearance test, you still need to find out why protein is in the urine to begin with and hopefully stop more damage from occuring.
