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- Feb 3, 2011
The HED of each given doses to these murine models are, well quite inordinately of A-50.NTP Toxicology and Carcinogenesis Studies of Oxymetholone
Oxymetholone is a synthetic anabolic steroid used to treat a variety of conditions, including hypogonadism and delayed puberty. It is also used to correct hereditary angioneurotic edema, manage carcinoma of the breast, promote a positive nitrogen balance following injury or surgery, and stimulate erythropoiesis. Considerable amounts of androgens are consumed by athletes in attempts to improve athletic performance. The National Institute of Environmental Health Sciences and the National Cancer Institute nominated oxymetholone for study based on its extensive illicit pharmaceutical use and the limited evidence that it is a potential human carcinogen. Male and female F344/N rats received oxymetholone (greater than 99% pure) in 0.5% methylcellulose by gavage for 16 days, 14 weeks, or 2 years, and male and female B6C3F1 mice received oxymetholone in 0.5% methylcellulose by gavage for 16 days or 14 weeks. Genetic toxicology studies were conducted in Salmonella typhimurium, cultured Chinese hamster ovary cells, and mouse peripheral blood erythrocytes.
No other AAS has demonstrated this level of outcome in standardised testing
Simple formulation to extrapolate the HED from these murine models to humans would be after one determines the kg weight of said murine model to determine the mg. "X"-mg×(90.718kg [sake of simplicity 200 lb human]÷kg of murine model)^(3÷4)=total mg HED.
Or, for the indolent individuals that don't like functional math. This easy-peasy calculator takes the guesswork out of it. Just be mindful to punch in the proper determined mg and kg of each representative model, e.g., human in kg and murine- rat or mouse.
Then this takes us to the vast differences between murine and humans hematological-immunological parameters.
Not taking away from the inherent potential of genotoxicity, bastardization of DNA stabilization, whatever, whatever. Yet to use murine models in extrapolations of bigly amounts A-50 isn't too reasonable.