It's a really good indicator of total # of atherogenic particles
This is a really good study on using ApoB vs LDL cholestrol for all cause mortality in statin therapy:
In statin-treated patients, elevated apoB and non-HDL cholesterol, but not LDL cholesterol, are associated with residual risk of all-cause mortality and myocardial infarction. Discordance analysis demonstrates that apoB is a more accurate marker of all-cause mortality risk in statin-treated...
pubmed.ncbi.nlm.nih.gov
Dr. Alan Sniderman's talk with Peter attia was really good on this subject; he discussed using ApoB and LpA (usually test this once since a subset of the population has this elevated) as two primary means of assessing atherogenic risk
He made a very good case for ApoB.
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The more Apo B particles within the lumen of an artery, the higher the number that becomes trapped and become part of the inflammatory process.
I would def emphasize as much on this as LDL P. Usually LDL C and LDL P are concordant in their relationship with one another, which is why ignoring a really high LDL number isn't a wise thing. But in the discordant group where the particle count can is disproportionate to the total count, it becomes almost a useless number without factoring in the other half