- Joined
- Jan 25, 2018
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- 842
they had nolvadex
nolvadex does NOT lower circulating levels of E2. it simply blocked it at the receptor
they had nolvadex
nolvadex does NOT lower circulating levels of E2. it simply blocked it at the receptor
nolvadex metabolites work as anti aromatase... at least in vitro.
need someone smarter to confirm if they behave the same in vivo
point taken. although AI's did not exist in the 70's, 80's and 90's so why weren't guys dropping with liver tumors
good topic that really needs debated more. were talking about using seriously powerful cancer drugs here with really strong side effects and for some using them for seriously long periods of time. concerning to say the least
No gh abuse to fuel them ? Just a thought ...
The average well developed gym rat these days is on more gh than someone finishing top 5 at the O in early 90s lol
No gh abuse to fuel them ? Just a thought ...
The average well developed gym rat these days is on more gh than someone finishing top 5 at the O in early 90s lol
well, guys in the 90's barely used anything, because why would they? not like winning was important to them
levrone only used gear the last 2 days before a show
Your ignorance shines in this post
Go learn what gh cost early 90s and none of your favorite chinese generics exist back then
It depends what camp you're in.
I'd prefer to keep E in range with an AI. High E in males isn't good for reasons already mentioned here.
I have a small case of gyno and E also causes me acne, so I'm left with using some sort of anti-estrogen. Even at low doses of aromatasable androgens I need an AE of some sort.
Recently, I've been using Ralox when E becomes an issue, or Tamox.
How's that work out for you? Obviously it'll stop gyno but what about all the other impacts of estrogen. I've been a pro ai kind of person but slowly learning that ai's make me feel like shit and trying to find an alternative other than really low dose test(I didn't decide to permanently shut myself down and be on trt for life to run little baby doses and merely be normal all the time). On the flip side, I hold lots of water with high e and it wears me out and makes me tired, along with a lack of sex drive. High e doesn't seem to bother my nipples unless I add tren.Recently, I've been using Ralox when E becomes an issue, or Tamox.
I also feel like shit over doing AI.How's that work out for you? Obviously it'll stop gyno but what about all the other impacts of estrogen. I've been a pro ai kind of person but slowly learning that ai's make me feel like shit and trying to find an alternative other than really low dose test(I didn't decide to permanently shut myself down and be on trt for life to run little baby doses and merely be normal all the time). On the flip side, I hold lots of water with high e and it wears me out and makes me tired, along with a lack of sex drive. High e doesn't seem to bother my nipples unless I add tren.
I've considered using tamoxifen but have failed to find clarity as to whether tamoxifen only blocks estrogen in breast tissue or whether it blocks out other e receptors too.
This may come across as condescending but many posts on this thread remind of how physicians are supposed to approach say something like smoking in young teenager patients... we are told not to focus on things like say pancreatic and lung cancer but to instead talk more about wrinkles, teeth discoloration, smell.... all those superficial things that people who cant fully grasp the importance of things they cant see.
No one likes gyno or to be bloated..ya know the superficial things ya see
Ya know what you will hate a lot more.. ruptured hepatic adenomas, estrogen dependent liver cancer, breast cancer, prostate cancer, DVT, pulmonary emboli.
Keep estrogen in range. If AI side effects bother you try using those which dont cross blood brain barrier or is actively effluxed ( hmm not sure thats really a word...) Get labs. If you are running more then TRT doses for prolonged periods of time you likely need an AI...well ok no one NEEDS anything but you SHOULD have an AI on board.
AI's not crossing the BBB? Which ones?This may come across as condescending but many posts on this thread remind of how physicians are supposed to approach say something like smoking in young teenager patients... we are told not to focus on things like say pancreatic and lung cancer but to instead talk more about wrinkles, teeth discoloration, smell.... all those superficial things that people who cant fully grasp the importance of things they cant see.
No one likes gyno or to be bloated..ya know the superficial things ya see
Ya know what you will hate a lot more.. ruptured hepatic adenomas, estrogen dependent liver cancer, breast cancer, prostate cancer, DVT, pulmonary emboli.
Keep estrogen in range. If AI side effects bother you try using those which dont cross blood brain barrier or is actively effluxed ( hmm not sure thats really a word...) Get labs. If you are running more then TRT doses for prolonged periods of time you likely need an AI...well ok no one NEEDS anything but you SHOULD have an AI on board.
AI's don't generally cross the blood-brain barrier, Letro may but not proven. Aromatase in the brain very limited but may be important for things like sex drive. BTW AIs can't reach aromatase in the ovaries either, which is why they don't work as well in premenopausal women. It seems likely they can't reach testicular aromatase either, I've seen this proposed in research but never proven, it fits with their limited ability to reduce E2 in males.AI's not crossing the BBB? Which ones?