- Nov 28, 2007
The study you posted does not address androgen receptor expression, up/down regulation at all. It only reports baseline and at 10 weeks. Therefore does not prove or disprove that alternative hypothesis. To more closely address the current hypothesis would be ti cite studeis that demonstrate a different androgen receptor modulation pattern such as increases lasting 8 weeks before down regulation via myostatin as Ir ecall seeing some years ago.You've provided data that isn't applicable to young men or trained athletes. Your "data" is on older men (60yrs+) with a tiny sample size of 12, including only 7 which received TE treatment.
Second, who does a TRT dose cycle and then doesn't change their diet or training for 6 moths?
You're argument "AR down regulation falls off a cliff and so do gains in muscle mass after 6 weeks" is nonsense.
I'll refer to the well known 1996 study thats often cited due to being the most applicable to us bodybuilders:
The Effects of Supraphysiologic Doses of Testosterone on Muscle Size and Strength in Normal Men
Full paper: https://www.nejm.org/doi/full/10.1056/nejm199607043350101
600mg of TE given to healthy men (not 60+, untrained) over 10 weeks. What did it find?
Bodyweight increased from 76kg to 82kg (6kg gained)
Fat Free Mass (FFM) increased from 65kg to 71kg (6kg gained)
Bench Press increased from 97kg to 119kg (22kg increase)
Squat increased from 102kg to 140kg (38kg increase)
Hows all that possible if your little theory of "cycles become less effective after 6 weeks"?
Sorry to blow a hole in your article, but you've cherry picked and written an entire article on data thats hardly relevant here. I know because I've done it too.