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- Jul 16, 2018
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Delaying Senescence ？Nature Medicine：Gene editing increased the life span of prematur
Aging increases the risk of many diseases, such as heart disease, cancer and alzheimer's disease.So scientists have been trying to find ways to slow down the aging process.
In 18TH February 2019 ,A new gene therapy may help slow aging, according to a new study published in the journal Nature Medicine.
Scientists from the Salk institute used CRISPR/Cas9 gene editing to suppress rapid aging in mice withHutchinson-Gilford progeries syndrome.The rare disease also afflicts humans.
"Aging is a complex process in which cells lose their function.So we need to find the key molecules that drive aging."Premature aging is an ideal model for studying aging because it allows us to design interventions and improve and validate them," said Juan Carlos Izpisua Belmonte, author of the study and a professor at the Salk institute's gene expression laboratory.
Cause of premature aging
Hutchinson-Gilford progeria is a rare and fatal genetic disease, and its main pathogenic factor is the mutation of LMNA gene.
In general, the LMNA gene expresses two similar proteins in the cell: lamin A and lamin C.Mutations in the gene turn fibrin A into progerin, A shortened, toxic version of lamin A that accumulates with age and worsens in progeria patients.
Both in humans and mice, premature aging can trigger many signs of aging, including DNA loss, heart dysfunction and a significantly shortened lifespan.
Use " magic scissors " to slow down aging
"Our goal is to reduce the toxicity of progerin accumulation in cells due to mutations in the LMNA gene.”
Lzpisua Belmonte laboratory Hsin-kai Liao Explained,they speculate that this can be achieved with CRISPR/Cas9 technology.
In general, using CRISPR/Cas9 technologytargeting lamin A and progerin can significantly improve the physiological health and life span of premature aging mice.The treated mice showed similar activity levels to normal mice, and their life expectancy increased by about 25%.
This is the first time that gene editing therapy has been used to treat progeria
"If we can increase the efficiency with which the virus infects various tissues, we can expect to extend life even further."
Izpisua Belmonte laboratorial postdoctoral Pradeep Reddy said .
Of course, this is just the beginning and a lot of research is still needed.
If this technology can be realized in our lifetime.Make us live to 150 or even 200. Would you do that ？
Aging increases the risk of many diseases, such as heart disease, cancer and alzheimer's disease.So scientists have been trying to find ways to slow down the aging process.
In 18TH February 2019 ,A new gene therapy may help slow aging, according to a new study published in the journal Nature Medicine.
Scientists from the Salk institute used CRISPR/Cas9 gene editing to suppress rapid aging in mice withHutchinson-Gilford progeries syndrome.The rare disease also afflicts humans.
"Aging is a complex process in which cells lose their function.So we need to find the key molecules that drive aging."Premature aging is an ideal model for studying aging because it allows us to design interventions and improve and validate them," said Juan Carlos Izpisua Belmonte, author of the study and a professor at the Salk institute's gene expression laboratory.
Cause of premature aging
Hutchinson-Gilford progeria is a rare and fatal genetic disease, and its main pathogenic factor is the mutation of LMNA gene.
In general, the LMNA gene expresses two similar proteins in the cell: lamin A and lamin C.Mutations in the gene turn fibrin A into progerin, A shortened, toxic version of lamin A that accumulates with age and worsens in progeria patients.
Both in humans and mice, premature aging can trigger many signs of aging, including DNA loss, heart dysfunction and a significantly shortened lifespan.
Use " magic scissors " to slow down aging
"Our goal is to reduce the toxicity of progerin accumulation in cells due to mutations in the LMNA gene.”
Lzpisua Belmonte laboratory Hsin-kai Liao Explained,they speculate that this can be achieved with CRISPR/Cas9 technology.
In general, using CRISPR/Cas9 technologytargeting lamin A and progerin can significantly improve the physiological health and life span of premature aging mice.The treated mice showed similar activity levels to normal mice, and their life expectancy increased by about 25%.
This is the first time that gene editing therapy has been used to treat progeria
"If we can increase the efficiency with which the virus infects various tissues, we can expect to extend life even further."
Izpisua Belmonte laboratorial postdoctoral Pradeep Reddy said .
Of course, this is just the beginning and a lot of research is still needed.
If this technology can be realized in our lifetime.Make us live to 150 or even 200. Would you do that ？
