That is 9-12 injections weekly--too much to maintain insulin sensitivity especially when no preventative measures are take to maintain it.
I have noticed that when insulin is used devoid of ancillaries, even when using it as little as 6X weekly, it can begin to decrease insulin sensitivity. I know that doesn't sound like much, but it does happen.
VERY TRUE
Dosage will play a signficant role in this, as well. Obviously, if someone was injecting only 1 IU at a time (completely worthless), they could inject it 20X a week without any problems, but when using effective doses of 15-40 IU per injection (caution: do not attempt to administer 40 IU. Doses such as this are reserved only for the largest competitors--guys who consume 200-300 grams of carbs during the workout window alone, along with significant qauntities of quickly digesting proteins), 4-5X weekly is about the maximum dosing frequency for maintaining sensitivity when ancillaries are absent. Some guys might call bullshit on that, but it is true. It really doesn't take much for the body to start losing sensitivity. I have seen some guys get away with 6X weekly, but that seems to be pushing it.
Agreed that body will react and adjust to nearly anything we do. This is something people fail to remember and why they stagnate or work backwards.
Question - I feel that upwards of 20iu is completely pointless (if you need THAT much your sensitivity is probably terrible. Their IS a ceiling to what your cells can uptake and the rate at which they do so. 40iu just seems like overkill, but for the sake of argument lets say it does work.... you dont feel doses like this will lead to tremendous buildup of visceral fat and additional fat gain to begin with? There is no possible way a "well fed" (glycogen loaded) bodybuilder (even the largest) is burning through their glycogen stores and an ADDITIONAL 300g carbs in a workout IMO and id venture to say scientifically (mathematically based on physiology) supported. There is not definite way to support this, but i think logic supports strongly. Possibly by "workout window" you mean pre, intra, post and post meal for the 300g total, which il accept, but still would not require 40iu for uptake unless multiple dosing spreading out over that period. Is that what you meant? Please clarify if you dont mind....
Now I am not saying that if you move from 4 to 6 applications that you are going to turn into a diabetic, but sensitivity will begin to decrease...and the more you push the frequency-dose, the worse it gets. This is why some guys can inject 40 IU at a time and barely even need to eat in order to maintain ther blood sugar. I have repeatedly witnessed guys injecting 20-25 IU and not eating anything at all for many hours---and their blood sugar barely budged. Of course, their blood sugar was already substantially elevated to begin with, signifying insulin resistance and a pre-diabetic state.
Which is terrible and why their protocol is way the fuck off....though il agree again that iv SEEN it and whole heartedly disagree with this practice.....personally i think this is one thing that was/is ruining looks
This is why I often recommend the pre-workout only program --not because its necessarily the best for maximizing growth--but because it can be used long-term without causing any meaningful decrease in sensitivity. It is also the single most effective time to use insulin.
At least the majority of the educated members agree here. Pending the bodypart and need for improvement i like a short acting post spike as well and combine the protocol with other PED's for amplification of workout performance and recovery.
To answer your question more directly, I couldn't say whether administering Metformin on your off-days, when using slin 9-12 x weekly, would be sufficient for maintaining normal insulin sensitivity, as total insulin dose, mefformin dose, and current sensitity would need to be factored into the equation. Even then, each person must be evaluated on case by case basis. Some people have more working against or for them than others, not to mention the issue of personal response. For example, if one person is engaged in high volume training, does 3-4 cardio sesions weekly, and follows a moderate carbohydrate diet, they are going to tolerate such a program far better than someone who trains with low volume, does no cardio, and follows a super-high carbohydrate diet loaded with refined grains. There are just too many variables that can affect the end result, which prevents me from being able to spit out a stock answer that applies to all.
Many members want a generalized answer so they can follow it.