Was reading an interesting piece by Big A discussing site enhancement and he mentioned one brand of oil that had active hormone in it but that that particular aspect of it was worthless because it had esterfied gear that would have no localized affect on the receptor sites where it was being shot. He said that these esterfied compounds all get broken down by the liver before the hormone could become useful in the body, kind of like how they say GH has no localized effect because it has to be converted into IGF-1 before it does it's work. So my questions are say testosterone is inert while it still has it's ester attached to it how does the process work that makes it active and then keeps it active? Doesn't the liver de-activate the hormone itself as well? So then how would it just take away the ester and then put the hormone back into the system freely and of course there's esters of different sizes as well so how does that play into the whole process? Maybe there's different pathways that the gear is broken down slowly and utilized in the body besides the liver or maybe the hormone still has a use even before the removal/breakdown of the ester? Also would 100% of a compound be bound when in an esterfied state or is there already some loose free compound involved from the raws manufacturing process? I'm a bit of that dude always asking why but it's some fascinating shit if you think about it, not to mention getting a handle on this shit definitely gonna change what I shoot where and for what reasons!