Do it! I've just started doing this (again) recently because I'm just sick of years now of stagnating-ass cardio with questionable results. I'd rather spend that other hour lifting.
Yeah, you might have to hold back on the drop sets and shit, but so what? Do another perfect set instead!
But what's been key for me, is this: Stopping when the reps on whatever exercise are no longer perfect. More light sets working up in weight, squeezing perfect form, and then heavier sets are fine. But stop when that lest rep loses form. Then do another perfect set.
This (for me) = less CNS stress, more direct muscle stress. And WAY better overall feeling on a daily basis.
Will I get massive this way? I guess, if I take more drugs and eat more. But Im happy feeling and looking good. Not taking two weeks to recover from a Leg day or even regressing in strength from a beat-up CNS.
I look better for doing this and most of all, I FEEL better, like the hormones are doing what they should. Sleep better, wake up hungry and horny, clear headed. Like you'd imagine bodybuilding SHOULD make you feel.