The last two times I ran DNP, it was for a short 2 week period. I ran it at 250mg the first week then 500mg the second. Fat loss was good. The side effects and just feeling drained were much more pronounced at 500mg. The most recent time I stuck to 250mg and the fat loss was the same, if not better, but I was also eating slightly lower cals overall so it's not a fair comparison. I just know in the past, longer runs of 500mg eventually had me with shortness of breath and pretty debilitating lethargy.
For me, 250 is the sweet spot. Crystal is about 89% as potent as powder. These are Dinitrio's numbers. I have also read 75%. But he also considers his lab grab crystal to be cleaner, purer and a smoother ride as compared to industrial grade powder that is sourced. He also said crystal clears faster but I believe this is inaccurate as I heave read powder actually has faster clearance. He believes his is a superior form (debatable) and he's adjusted his caps (he says) to factor out to the same dose for dose as 250mg powder. I'm running his crystal now for the first time. It does seem smoother but it's early to say and it could just be because it's slightly less potent.
Every 100mg of DNP (crystal/powder) elevates metabolic rate 11%/15%. I still find it hard to believe that merely doubling your dose correlates with a nice simple doubling of its metabolic increase and resulting fat loss. Is it more effective, yes, it has to be. But for me it's not worth the sides to go higher. It degrades my training and cardio enough it could even offset the benefit.
For simple math, assuming 200mg, your blood levels would peak at 390mg after about 2 weeks. A 22% boost is crystal and 30% is powder (roughly). Do I believe simply doubling that dose means 60% and doubling your fat loss, no. Not in the real world. I think based on concentration build up and long half-life, 3 weeks is probably the perfect time frame. 1 week is too short, 2 is fine.