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Berberine and protein degradation?

powerof2

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Atrogin-1 affects muscle protein synthesis and degradation when energy metabolism is impaired by the antidiabetes drug berberine. ... RESULTS: Berberine administration decreased protein synthesis and increased degradation in muscles of normal and db/db mice.

Without post the hole study. I couldn’t find the answer in a search. I’m sure it has been beaten down already. So before I throw my berberine in the garbage. What’s the take on this.


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suppdude

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You can offset this by heavy resistance training.
 

powerof2

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I have been using metformin and berberine for around 16 months. Can’t say I have gotten big change in a year. I stay lean.


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suppdude

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No need to use it post-workout.

And using Berb and metformin together isn't recommended together.
 

richiec

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Are you using AAS? Pretty sure they will offset the berberine affects on protein synthesis
 

rookx750

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Are you using AAS? Pretty sure they will offset the berberine affects on protein synthesis

Not if it is totally alters/stopping the mechanism for a period of time. I would agree that it isn’t because I take that multiple times a day and have definitely kept everything while losing fat.
 

powerof2

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Taking plenty ass and Gh. I just don’t know that when it says it block mtor how much of it can be brought back with ass training ect


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