Total Estrogens are composed of three sub-type's of Estrogen; E1→Estrone, E2→Estradiol and E3→ Estriol.
Aromatization of E1(Estrone) is mainly from androstenedione. What should be known is E2 and E1 can be converted into each other, and both can be inactivated via hydroxylation. If one has a very high adrenal synthesis of 17-hydroxyprogesterone→DHEA→androstenedione one could suspect elevated levels of E1, therefore elevated levels of E2. Outside of testosterone atomization too E2.
All AI's have hepatic clearance, in which means they all share the possibility of hepatotoxicity.Therefore altered lipids.
Something to keep in mind, estradiol is more thrombotic than testosterone.
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