Emeric, with all do respect everyone in this thread is fucking with you.
No one is interested in humanofort or 10mg test a day.
This is a thread about insulin and lots of it. With the goal being to get large as fuck. Meaning the people in this thread are faaar from your target audience.
With that said can we get back on track here. This was starting out as an excellent thread and I was learning something.
I understand, I was not the one drag the Humanofort to the Insulin tread, some one made a sarcastic post. Actually Humanofor is good idea to incorporate for insulin users.
FGF-1 modulates pancreatic β-cell functions/metabolism: An in vitro study
Author links open overlay panelPawel A. Kolodziejski a, Maciej Sassek a, Jakub Bien a, Natalia Leciejewska a, Dawid Szczepankiewicz a, Beata Szczepaniak a, Malgorzata Wojciechowska b, Leszek Nogowski a, Krzysztof W. Nowak a, Mathias Z. Strowski c d, Ewa Pruszynska-Oszmalek a
Abstract
Fibroblast growth factor 1 (FGF-1), also known as acidic fibroblast growth factor (aFGF), is a growth factor and signaling protein encoded by the
Fgf1 gene. Previous studies have shown that FGF-1 may also participate in the regulation of glucose metabolism, both in healthy organisms and in pathological conditions such as diabetes. Because insulin the main regulator of glucose metabolism is secreted from pancreatic beta cells, we investigated whether FGF-1 directly affects the secretion of this hormone and regulates the metabolism of beta cells and isolated pancreatic islets. By using insulin-producing INS-1E cells and isolated pancreatic islets, we investigated the effect of FGF-1 on cell proliferation, viability, apoptosis, and insulin expression and secretion. Our study showed that FGF1 and fibroblast growth factor receptors (
FgfRs:
FgfR1,
FgfR2,
FgfR3, and
FgfR4) are present on mRNA level in INS-1E cells and isolated rat pancreatic islets. We also proved that FGF1 stimulates the proliferation of INS-1E beta cells and enhances the viability of these cells and that of isolated pancreatic islet cells, and that ERK1/2 kinase is involved in the regulation of INS-1E cell proliferation. Moreover, we found that FGF1 can stimulate insulin secretion from both INS-1E cells and isolated rat pancreatic islets. Thus, the FGF1 peptide increases cell survival and decreases cell death. The obtained results indicate that FGF1 may play a role in controlling the physiology and metabolism of pancreatic beta cells as well as glycemia.